Investigating how dengue virus-induced metabolic changes affect the host immune response and how to develop Immunomodulatory strategies

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 25, 2025

Dengue virus (DENV) infection imposes a significant global health burden, driven by its ability to manipulate host cellular processes facilitate replication and evade immune defenses. This review explores the complex interplay between DENV, immunometabolism, signaling pathways. DENV induces metabolic reprogramming, including glycolytic upregulation, lipid droplet utilization through lipophagy, alterations in amino acid metabolism, fulfill energy biosynthetic needs. The also disrupts mitochondrial dynamics, leading increased reactive oxygen species (ROS) production, which modulates responses but may contribute oxidative stress severe pathology. Concurrently, hijacks pathways, PI3K/Akt, NF-κB, JAK/STAT, suppress apoptosis, type I interferon responses, drive pro-inflammatory cytokine production. these pathways highlights dual role of processes: enabling viral while activating antiviral responses. examines potential therapeutic strategies targeting combat infection, glycolysis inhibitors, metabolism modulators, host-directed therapies. While progress has been made understanding DENV-induced further research is needed elucidate precise molecular mechanisms translate findings into clinical applications. study underscores importance integrating insights identify novel targets against related flaviviruses, addressing critical need for effective interventions.

Language: Английский

A Comprehensive Review of Dengue Fever: Epidemiological Trends, Diagnostic Approaches, Novel Therapeutic Strategies, and Challenges in Vaccine Advancement over the Past Five Years in the Context of Globalization and Climatic Change

Futuristic Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 10 - 16

Published: Sept. 30, 2024

Dengue fever, which is caused by the dengue virus and primarily disseminated Aedes mosquitoes, constitutes a significant global health issue, indicating 400 million infections 22,000 fatalities each year. The clinical presentation of disease varies widely, encompassing both asymptomatic manifestations severe forms such as hemorrhagic fever (DHF) shock syndrome (DSS), particularly during secondary attributable to antibody-dependent enhancement (ADE). increasing incidence influenced several factors, including climate change, globalization, urbanization, resulting in recurrent epidemics, Southeast Asia Indian subcontinent. current diagnostic methodologies encounter difficulties, often intersecting with other medical conditions, thereby necessitating implementation advanced techniques for precise identification. Management predominantly entails supportive care traditional interventions, while substantial deficiencies persist realm effective therapeutic alternatives vaccine innovation. Notwithstanding advancements live attenuated vaccines, universally has yet be achieved. Ongoing research imperative confront these challenges establish preventive measures against fever.

Language: Английский