Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155785 - 155785
Published: Dec. 19, 2024
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 21, 2025
Language: Английский
Citations
2
World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)
Published: Feb. 1, 2025
Language: Английский
Citations
0
Exploration of Medicine, Journal Year: 2025, Volume and Issue: 6
Published: March 4, 2025
Cervical cancer is the fourth leading cause of cancer-related deaths among women worldwide, causing over 660,000 new cases and 350,000 in 2022, with a disproportionately high burden low-resource countries where access to treatment limited. Human papillomavirus (HPV) common sexually transmitted infection that accounts for approximately 95% cervical cases. Persistent HPV can progress dysplasia, categorized into varying severities (CIN1, CIN2, CIN3), which significantly increases risk. The mechanism HPV-induced malignancy involves disruption cellular apoptosis by integrating viral genetic material cells, particularly within transformation zone. proteins E6 E7 play pivotal roles carcinogenesis inhibiting tumor suppressor proteins, promoting uncontrolled cell proliferation, evading immune responses, ultimately driving progression toward malignancy. Timely detection intervention are essential managing HPV-related cancers. Preventative measures such as vaccination have demonstrated substantial efficacy. Six vaccines targeting high-risk (HR) strains recommended before sexual activity or exposure. Despite these advancements, barriers, misinformation, logistical challenges, limited healthcare infrastructure, persist, underserved regions. Advances diagnostic therapeutic technologies offered avenues addressing challenges. Next-generation sequencing CRISPR gene editing emerging promising tools enable precise targeted interventions. Furthermore, artificial intelligence (AI) imaging innovations enhanced accuracy personalized care. Pap smears DNA testing indispensable early detection. To tackle globally, multifaceted approach required. Public health education, programs, research, international collaboration crucial. campaigns should combat strengthen focus on novel therapies, screening technologies, next-generation sequencing.
Language: Английский
Citations
0
Pharmacogenetics and Pharmacogenomics, Journal Year: 2025, Volume and Issue: 2, P. 29 - 36
Published: March 4, 2025
Introduction. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) has been recognized as a revolutionary advancement in the biomedical field, offering unparalleled precision and versatility genome editing. This review examines transformative potential of diagnostic therapeutic tool for various diseases. Methods. A systematic was conducted following PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) guidelines. comprehensive search PubMed, Scopus, Google Scholar, Web Science performed to identify relevant Studies published between January 2015 2025. The inclusion criteria focused on peer-reviewed articles discussing CRISPR-based diagnostics, applications, technological advancements. were screened, assessed quality using CASP framework, categorized into thematic areas analysis. Results. platforms, such SHERLOCK DETECTR, analyzed their sensitivity rapidity detecting pathogens, cancer biomarkers, genetic mutations. Emerging innovations, including prime base editing, have explored role expanding capabilities CRISPR. Additionally, advancements delivery mechanisms use alternative Cas proteins discussed impact clinical applicability. Conclusions. Ethical, regulatory, accessibility challenges associated with technology are highlighted, emphasizing importance responsible development equitable deployment. connects cutting-edge translational underscores significant shaping future medicine global health.
Language: Английский
Citations
0
Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: April 7, 2025
CRISPR/Cas9 technology has revolutionized genetic and biomedical research in recent years. It enables editing modulation of gene function with an unparalleled precision effectiveness. Among the various applications prospects this technology, opportunities it offers unraveling molecular underpinnings a myriad central nervous system diseases, including neurodegenerative disorders, psychiatric conditions, developmental abnormalities, are unprecedented. In review, we highlight CRISPR/Cas9-based therapeutics as promising strategy for management Alzheimer's disease transformative impact on AD research. Further, emphasize role generating accurate models identification novel therapeutic targets, besides CRISPR-based therapies aimed at correcting AD-associated mutations modulating processes. Furthermore, delivery systems reviewed potential non-viral nanotechnology-based carriers overcoming critical limitations effective is discussed. Overall, review highlights promise intricate processes underlying development AD, discusses its limitations, ethical concerns several challenges efficient across BBB, ensuring specificity, avoiding off-target effects. This article can be helpful better understanding based approaches way forward utilizing enormous targeted, gene-specific treatments that could change trajectory debilitating incurable illness.
Language: Английский
Citations
0
Translational Oncology, Journal Year: 2024, Volume and Issue: 51, P. 102226 - 102226
Published: Dec. 1, 2024
Language: Английский
Citations
3
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155785 - 155785
Published: Dec. 19, 2024
Language: Английский
Citations
1