Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes DOI Creative Commons

Yuwei Wu,

Yuming Jin,

Linghui Deng

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(5), P. e259960 - e259960

Published: May 13, 2025

Importance Exposure to high altitudes elicits multiple adaptive mechanisms that intricately impact the entire body, causing deleterious health outcomes. However, high-altitude exposure effects on accelerated aging and aging-related changes remain uncertain. Objective To comprehensively assess associations of with overall related provide insights into treatment prevention aging-associated deficits in populations living areas. Design, Setting, Participants This population-based cross-sectional study used data from 2 prospective studies Western China: West China Natural Population Cohort (WCNPCS) Health Aging Trend (WCHAT). The WCNPCS cohort was constructed May 2019 June 2021. Data were collected participants aged 18 years older 4 populous regions (Mianzhu, Longquan, Pidu, Ganzi) Sichuan Province. WCHAT initiated 2018 recruited 50 various (Sichuan, Yunnan, Guizhou, Xinjiang). selected via sequential cluster sampling permanent residents participating community. for present analyzed between March October 2024. participants’ determined using global Shuttle Radar Topography Mission based residential addresses. High-altitude areas refer greater than or equal 1500 m (4921 feet) above mean sea level. Main Outcomes Measures Biological (BA) acceleration (AA) measured through Klemera–Doubal Age (KDM-BA) PhenoAge methods. Multidimensional metrics questionnaire, measurement, self-report. Results A total 9846 (mean [SD] age, 55.73 [11.06] years; 6730 women [68.35%]) 3593 62.27 [8.40] 2253 [62.71%]) included. at presented increased KDM-BA by 0.85 0.71 cohort. results similar, even larger effect sizes (WCNPCS, β, 2.08 95% CI, 1.77-2.39 WCHAT, 2.23 1.91-2.54 years). association biologically particularly pronounced among smokers. Associations multidimensional also observed. Conclusions Relevance These findings suggest extended periods may hasten BA contribute onset illnesses. Implementing public interventions individuals residing aid alleviating disease burden within these communities.

Language: Английский

Evaluating the Risks of Heated Tobacco Products: Toxicological Effects on Two Selected Respiratory Bacteria and Human Lung Cells DOI Creative Commons
Salvatore Furnari, Rosalia Emma, Massimo Caruso

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 70 - 70

Published: Jan. 21, 2025

Heated tobacco products (THPs) are increasingly promoted as potential harm reduction tools, offering an alternative to traditional cigarettes. Despite these claims, understanding of their toxicological impact on respiratory health and associated microbial communities is limited. Comprehensive investigations needed elucidate the biological mechanisms implications with use. Methods: This study evaluated effects aerosols produced by THPs (IQOS 3 Duo Heets “Sienna Selection”) in comparison conventional cigarette smoke (1R6F). Antibacterial activity was using Streptococcus pneumoniae Klebsiella representative species microbiota through agar diffusion assays MIC/MBC determinations. Cytotoxicity assessed human lung fibroblast cells (MRC5) neutral red uptake (NRU) assay, whereas mutagenicity investigated Ames test. Results: THP demonstrated ability inhibit growth both S. K. pneumoniae, exerting bacteriostatic at lower concentrations bactericidal higher concentrations. While antibacterial might initially seem beneficial against pathogens such they raise concerns about disruption balance, particularly relation pneumoniae. microbiological effects, minimal cytotoxicity fibroblasts lacked detectable mutagenic activity, contrasting significant caused smoke. Conclusions: present a reduced short-term profile compared cigarettes; however, microorganisms deserve attention. The observed inhibition commensal bacteria highlights need explore changes ecosystem that could affect health. These findings highlight for additional studies evaluate long-term effect use stability overall ecosystem.

Language: Английский

Citations

0
Biological age construction for prediction of mortality in the Chinese population DOI

Kaiyue Wang,

Xiang Gao, Ying Liu

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress DOI Creative Commons
Lin Song,

Bozhao Wang,

Jian Li

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 624 - 624

Published: April 27, 2025

Klotho, an anti-aging protein, has been extensively studied in systemic conditions such as chronic kidney disease and cardiovascular disorders. In recent years, its pivotal protective role clinical significance various oral maxillofacial diseases have increasingly demonstrated. It demonstrated that Klotho regulates oxidative stress, apoptosis, inflammation, fibrosis via multiple molecular signaling pathways, including Nrf2, NF-κB, PI3K/Akt/FoxO1, insulin/IGF-1, FGF/FGFR, Wnt/β-catenin. Consequently, these regulatory effects observed periodontitis, squamous cell carcinoma, malignant salivary gland tumors, submucous fibrosis, etc. Moreover, the decreased expression or dysfunctional activity of is frequently associated with onset progression diseases. This study provides a comprehensive review underlying mechanisms advances research within realm diseases, offering novel perspectives for future basic investigations.

Language: Английский

Citations

0
Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes DOI Creative Commons

Yuwei Wu,

Yuming Jin,

Linghui Deng

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(5), P. e259960 - e259960

Published: May 13, 2025

Importance Exposure to high altitudes elicits multiple adaptive mechanisms that intricately impact the entire body, causing deleterious health outcomes. However, high-altitude exposure effects on accelerated aging and aging-related changes remain uncertain. Objective To comprehensively assess associations of with overall related provide insights into treatment prevention aging-associated deficits in populations living areas. Design, Setting, Participants This population-based cross-sectional study used data from 2 prospective studies Western China: West China Natural Population Cohort (WCNPCS) Health Aging Trend (WCHAT). The WCNPCS cohort was constructed May 2019 June 2021. Data were collected participants aged 18 years older 4 populous regions (Mianzhu, Longquan, Pidu, Ganzi) Sichuan Province. WCHAT initiated 2018 recruited 50 various (Sichuan, Yunnan, Guizhou, Xinjiang). selected via sequential cluster sampling permanent residents participating community. for present analyzed between March October 2024. participants’ determined using global Shuttle Radar Topography Mission based residential addresses. High-altitude areas refer greater than or equal 1500 m (4921 feet) above mean sea level. Main Outcomes Measures Biological (BA) acceleration (AA) measured through Klemera–Doubal Age (KDM-BA) PhenoAge methods. Multidimensional metrics questionnaire, measurement, self-report. Results A total 9846 (mean [SD] age, 55.73 [11.06] years; 6730 women [68.35%]) 3593 62.27 [8.40] 2253 [62.71%]) included. at presented increased KDM-BA by 0.85 0.71 cohort. results similar, even larger effect sizes (WCNPCS, β, 2.08 95% CI, 1.77-2.39 WCHAT, 2.23 1.91-2.54 years). association biologically particularly pronounced among smokers. Associations multidimensional also observed. Conclusions Relevance These findings suggest extended periods may hasten BA contribute onset illnesses. Implementing public interventions individuals residing aid alleviating disease burden within these communities.

Language: Английский

Citations

0