Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks DOI Creative Commons
Eleonora Calzoni, Nicolò Montegiove, Alessio Cesaretti

et al.

Biophysica, Journal Year: 2024, Volume and Issue: 4(4), P. 724 - 746

Published: Dec. 21, 2024

Microplastics (MPs) are widespread environmental pollutants that have drawn significant attention due to their possible health risks humans and animals, as well extensive presence in ecosystems. Recent growing evidence highlights a remarkable relationship between MPs extracellular vesicles (EVs), nanoscale particles involved intercellular communication. The purpose of this review was investigate how the relationships EVs can affect cellular functions interaction could impact conditions leading broader ecological risks. patterns bioactivity both strongly influenced by biophysical characteristics such hydrophobicity, surface charge, particle size, which received particular from scientific community. studies indicate EV distribution capacity function appropriately biological systems. Additionally, modify molecular cargo EVs, may result alterations cell signaling pathways. Understanding interactions provide important opportunities comprehend potential effects on human systems, especially when it comes cancer development, endocrine, metabolic, inflammatory disorders, disruptions. This emphasizes necessity multidisciplinary research clarify mechanisms regulating EVs.

Language: Английский

Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics DOI Creative Commons
Dong-Seon Kim, Dongmin Kim, Hee-Kyung Kim

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Microplastics (MPs), plastic particles with a diameter of < 5 mm, are intentionally produced or formed by the breakdown variety larger plastics. Polyethylene terephthalate (PET) is common source MPs and PET-MPs prevalent in environment. Owing to their persistence, can enter ecosystems, air, food sources, posing significant health risks. This study aimed investigate toxicological effects vivo accumulation smaller than 10 µm. To track biodistribution, fluorescently labeled were prepared. Particle size morphology confirmed using physical chemical characterization. Following oral administration ICR (CD-1®) outbred mice, occurred predominantly lungs, as IVIS spectrum CT analysis ex imaging. Toxicity assays revealed development granulomatous inflammation lungs at medium high doses, indicating concentration-dependent response. The recorded no-observed-adverse-effect levels 1.75 mg/kg for males 7 females. highlights potential induce persistent respiratory tissues reveals need further research support regulatory standards long-term MP exposure.

Language: Английский

Citations

0
Climate Change Exacerbates Microplastic Pollution: Environmental Behavior and Human Health Risks DOI
Yang Zheng, Marı́a Dolores Hernando, ‪Damià Barceló

et al.

Current Opinion in Environmental Science & Health, Journal Year: 2025, Volume and Issue: unknown, P. 100608 - 100608

Published: Feb. 1, 2025

Language: Английский

Citations

0
Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis DOI Open Access
Ivan Šoša,

Loredana Labinac,

Manuela Perković

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

Citations

0
A comprehensive review on exposure to toxins and health risks from plastic waste: Challenges, mitigation measures, and policy interventions DOI Creative Commons

Salia S. Sheriff,

Abdulfatah Abdu Yusuf, Oluwole Akiyode

et al.

Waste Management Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 100204 - 100204

Published: April 1, 2025

Language: Английский

Citations

0
Microplastics exposure causes premature ovarian aging via inducing mitochondrial dysfunction DOI
Xing Duan,

Li‐Shu Li,

Wen-Jiao Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Ovarian aging represents a significant risk factor for female infertility, primarily due to decline in ovarian reserve and diminished oocyte quality. However, whether microplastics (MPs) exposure poses potential inducing the underlying mechanisms remain poorly understood. In this study, we demonstrated that MPs accelerates aging, characterized by elevated expression of senescence markers (p16 p21) increased fibrosis. Mechanistic analysis indicated led inflammatory damage mitochondrial dysfunction, which contribute reduced reserve. Furthermore, compromised maturation competence embryo development triggering dysfunction DNA damage. Multi-omics identified L-arginine as crucial metabolite protects oocytes from MPs-induced aging. Notably, supplementation significantly mitigated phenotypes induced MPs, evidenced fibrosis, damage, alongside enhanced These findings provide theoretical support reproductive protection against inform environmental assessments.

Language: Английский

Citations

0
Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks DOI Creative Commons
Eleonora Calzoni, Nicolò Montegiove, Alessio Cesaretti

et al.

Biophysica, Journal Year: 2024, Volume and Issue: 4(4), P. 724 - 746

Published: Dec. 21, 2024

Microplastics (MPs) are widespread environmental pollutants that have drawn significant attention due to their possible health risks humans and animals, as well extensive presence in ecosystems. Recent growing evidence highlights a remarkable relationship between MPs extracellular vesicles (EVs), nanoscale particles involved intercellular communication. The purpose of this review was investigate how the relationships EVs can affect cellular functions interaction could impact conditions leading broader ecological risks. patterns bioactivity both strongly influenced by biophysical characteristics such hydrophobicity, surface charge, particle size, which received particular from scientific community. studies indicate EV distribution capacity function appropriately biological systems. Additionally, modify molecular cargo EVs, may result alterations cell signaling pathways. Understanding interactions provide important opportunities comprehend potential effects on human systems, especially when it comes cancer development, endocrine, metabolic, inflammatory disorders, disruptions. This emphasizes necessity multidisciplinary research clarify mechanisms regulating EVs.

Language: Английский

Citations

1