Therapeutic Potential of Plant-Derived Small Extracellular Vesicles in Sepsis: A Network Meta-analysis DOI Creative Commons

Wen-Yi Lai,

Ching-Wei Chuang, Yu-Chen Huang

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107795 - 107795

Published: May 1, 2025

Sepsis is a life-threatening condition characterized by systemic inflammation and multi-organ dysfunction. Plant-derived small extracellular vesicles (sEVs) have emerged as promising therapeutic agents due to their antioxidant, anti-inflammatory, immunomodulatory properties. This study conducted network meta-analysis identify the most effective plant-derived sEVs for reducing sepsis-induced oxidative stress. The analysis included 13 studies evaluating 10 in sepsis-mimicking conditions, with primary outcomes focused on cytokine levels reactive oxygen species (ROS) production vitro vivo. Secondary nuclear factor erythroid 2-related 2 (Nrf2) expression cell viability. protocol was registered PROSPERO (CRD420251011005). Ginger-derived were identified effective, significantly pro-inflammatory cytokines (interleukin-6 tumor necrosis factor-α), increasing anti-inflammatory (interleukin-10), suppressing ROS production. They also enhanced Nrf2 improved viability, highlighting role antioxidant defense cytoprotection. In conclusion, ginger-derived are mitigating oxidation both vivo models.

Language: Английский

Therapeutic Potential of Plant-Derived Small Extracellular Vesicles in Sepsis: A Network Meta-analysis DOI Creative Commons

Wen-Yi Lai,

Ching-Wei Chuang, Yu-Chen Huang

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107795 - 107795

Published: May 1, 2025

Sepsis is a life-threatening condition characterized by systemic inflammation and multi-organ dysfunction. Plant-derived small extracellular vesicles (sEVs) have emerged as promising therapeutic agents due to their antioxidant, anti-inflammatory, immunomodulatory properties. This study conducted network meta-analysis identify the most effective plant-derived sEVs for reducing sepsis-induced oxidative stress. The analysis included 13 studies evaluating 10 in sepsis-mimicking conditions, with primary outcomes focused on cytokine levels reactive oxygen species (ROS) production vitro vivo. Secondary nuclear factor erythroid 2-related 2 (Nrf2) expression cell viability. protocol was registered PROSPERO (CRD420251011005). Ginger-derived were identified effective, significantly pro-inflammatory cytokines (interleukin-6 tumor necrosis factor-α), increasing anti-inflammatory (interleukin-10), suppressing ROS production. They also enhanced Nrf2 improved viability, highlighting role antioxidant defense cytoprotection. In conclusion, ginger-derived are mitigating oxidation both vivo models.

Language: Английский

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