NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer
Chengcheng Zhao,
No information about this author
Jian Qin,
No information about this author
Dingyu Zhang
No information about this author
et al.
Pharmaceutical Development and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 19
Published: Jan. 7, 2025
In
this
paper,
the
pH-sensitive
targeting
functional
material
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl
methyl
carbonate
(NGR-PEtOz-CHMC,
NPC)
modified
quercetin
(QUE)
liposomes
(NPC-QUE-L)
was
constructed.
The
structure
of
NPC
confirmed
by
infrared
spectroscopy
(IR)
and
nuclear
magnetic
resonance
hydrogen
spectrum
(1H-NMR).
Pharmacokinetic
results
showed
that
accumulation
QUE
in
plasma
NPC-QUE-L
group
1.28
times
2.43
Solution
QUE-L
groups,
respectively.
release
amount
an
acidic
environment
significantly
higher
than
physiological
pH
value.
order
tumor
cell
inhibition
rate
different
environments
>
PC-QUE-L
QUE-L.
addition,
cellular
uptake
NPC-modified
PC-modified
unmodified
liposomes,
indicating
had
good
pH-sensitivity
targeting.
triple-negative
breast
cancer
(TNBC)
model,
relative
proliferation
is
about
73%,
which
better
solution
group.
Western
blot
show
can
effectively
reduce
expression
α-smooth
actin
transforming
growth
factor-β1
tissues,
improve
degree
fibrosis.
study,
could
endow
with
stability,
pH-sensitivity,
targeting,
provides
a
reference
for
improving
solubility
poorly
soluble
natural
drug
components.
Language: Английский
Basic Science, New Target Investigation, and Research in Childhood Cancer
Hafeez Abdelhafeez,
No information about this author
Victor M. Santana
No information about this author
Published: Jan. 1, 2025
Language: Английский
Transforming Oncology: Advancing Cancer Management with Three-dimensional Technology
Ankit Badge,
No information about this author
Madhukar Tikas,
No information about this author
Nandkishor Bankar
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et al.
Nigerian Postgraduate Medical Journal,
Journal Year:
2025,
Volume and Issue:
32(1), P. 77 - 78
Published: Jan. 1, 2025
Language: Английский
Innovative approaches in skin therapy: The rise of organoid cultivation
R. Zhou,
No information about this author
Xin Luo,
No information about this author
Shaokun Chen
No information about this author
et al.
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 162248 - 162248
Published: April 1, 2025
Language: Английский
Tailored 3D microphantoms: An essential tool for quantitative phase tomography analysis of organoids
Journal of Applied Biomedicine,
Journal Year:
2025,
Volume and Issue:
45(2), P. 247 - 257
Published: April 1, 2025
Language: Английский
Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
18(1), P. 14 - 14
Published: Dec. 25, 2024
Chemoresistance
is
a
major
obstacle
in
high-grade
serous
carcinoma
(HGSC)
treatment.
Although
many
patients
initially
respond
to
chemotherapy,
the
majority
of
them
relapse
due
Carboplatin
and
Paclitaxel
resistance.
Drug
repurposing
has
surfaced
as
potentially
effective
strategy
that
works
synergically
with
standard
chemotherapy
bypass
chemoresistance.
In
prior
study,
using
2D
cultures
two
HGSC
chemoresistant
cell
lines,
it
was
demonstrated
combining
or
Pitavastatin
Ivermectin
resulted
most
notable
synergy.
Acknowledging
culture
systems
are
limited
reflecting
tumor
architecture,
3D
were
generated
provide
insights
on
treatment
efficacy
tests
more
complex
models.
We
aimed
investigate
whether
offers
therapeutic
benefits
Cultrex-based
model.
Here,
cytotoxicity
Paclitaxel,
both
alone
combination
Ivermectin,
analyzed
OVCAR8
PTX
R
C,
cultures.
Cellular
viability
assessed
CellTiter-Glo®
Luminescent
assays.
Also,
explored
synergistic
interactions
zero
interaction
potency,
Loewe,
Bliss
independence,
High-single
agent
reference
Our
research
indicates
chemotherapeutic
drugs
yields
significantly
cytotoxic
effects
than
alone.
For
all
combinations
tested,
at
least
one
model
indicated
an
additive
effect;
however,
only
consistently
effect
across
lines
cultured
models,
well
four
synergy
models
used
assess
drug
interactions.
Combining
highest
strongest
for
compared
Language: Английский