Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures DOI Creative Commons
Mariana Nunes, Sara Ricardo

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 14 - 14

Published: Dec. 25, 2024

Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC) treatment. Although many patients initially respond to chemotherapy, the majority of them relapse due Carboplatin and Paclitaxel resistance. Drug repurposing has surfaced as potentially effective strategy that works synergically with standard chemotherapy bypass chemoresistance. In prior study, using 2D cultures two HGSC chemoresistant cell lines, it was demonstrated combining or Pitavastatin Ivermectin resulted most notable synergy. Acknowledging culture systems are limited reflecting tumor architecture, 3D were generated provide insights on treatment efficacy tests more complex models. We aimed investigate whether offers therapeutic benefits Cultrex-based model. Here, cytotoxicity Paclitaxel, both alone combination Ivermectin, analyzed OVCAR8 PTX R C, cultures. Cellular viability assessed CellTiter-Glo® Luminescent assays. Also, explored synergistic interactions zero interaction potency, Loewe, Bliss independence, High-single agent reference Our research indicates chemotherapeutic drugs yields significantly cytotoxic effects than alone. For all combinations tested, at least one model indicated an additive effect; however, only consistently effect across lines cultured models, well four synergy models used assess drug interactions. Combining highest strongest for compared

Language: Английский

NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer DOI
Chengcheng Zhao, Jian Qin,

Dingyu Zhang

et al.

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Jan. 7, 2025

In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (1H-NMR). Pharmacokinetic results showed that accumulation QUE in plasma NPC-QUE-L group 1.28 times 2.43 Solution QUE-L groups, respectively. release amount an acidic environment significantly higher than physiological pH value. order tumor cell inhibition rate different environments > PC-QUE-L QUE-L. addition, cellular uptake NPC-modified PC-modified unmodified liposomes, indicating had good pH-sensitivity targeting. triple-negative breast cancer (TNBC) model, relative proliferation is about 73%, which better solution group. Western blot show can effectively reduce expression α-smooth actin transforming growth factor-β1 tissues, improve degree fibrosis. study, could endow with stability, pH-sensitivity, targeting, provides a reference for improving solubility poorly soluble natural drug components.

Language: Английский

Citations

0
Basic Science, New Target Investigation, and Research in Childhood Cancer DOI

Hafeez Abdelhafeez,

Victor M. Santana

Published: Jan. 1, 2025

Language: Английский

Citations

0
Transforming Oncology: Advancing Cancer Management with Three-dimensional Technology DOI Creative Commons
Ankit Badge,

Madhukar Tikas,

Nandkishor Bankar

et al.

Nigerian Postgraduate Medical Journal, Journal Year: 2025, Volume and Issue: 32(1), P. 77 - 78

Published: Jan. 1, 2025

Language: Английский

Citations

0
Innovative approaches in skin therapy: The rise of organoid cultivation DOI
R. Zhou, Xin Luo,

Shaokun Chen

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162248 - 162248

Published: April 1, 2025

Language: Английский

Citations

0
Tailored 3D microphantoms: An essential tool for quantitative phase tomography analysis of organoids DOI
Michał Ziemczonok, Sylvia Desissaire,

J. M. Neri

et al.

Journal of Applied Biomedicine, Journal Year: 2025, Volume and Issue: 45(2), P. 247 - 257

Published: April 1, 2025

Language: Английский

Citations

0
Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures DOI Creative Commons
Mariana Nunes, Sara Ricardo

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 14 - 14

Published: Dec. 25, 2024

Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC) treatment. Although many patients initially respond to chemotherapy, the majority of them relapse due Carboplatin and Paclitaxel resistance. Drug repurposing has surfaced as potentially effective strategy that works synergically with standard chemotherapy bypass chemoresistance. In prior study, using 2D cultures two HGSC chemoresistant cell lines, it was demonstrated combining or Pitavastatin Ivermectin resulted most notable synergy. Acknowledging culture systems are limited reflecting tumor architecture, 3D were generated provide insights on treatment efficacy tests more complex models. We aimed investigate whether offers therapeutic benefits Cultrex-based model. Here, cytotoxicity Paclitaxel, both alone combination Ivermectin, analyzed OVCAR8 PTX R C, cultures. Cellular viability assessed CellTiter-Glo® Luminescent assays. Also, explored synergistic interactions zero interaction potency, Loewe, Bliss independence, High-single agent reference Our research indicates chemotherapeutic drugs yields significantly cytotoxic effects than alone. For all combinations tested, at least one model indicated an additive effect; however, only consistently effect across lines cultured models, well four synergy models used assess drug interactions. Combining highest strongest for compared

Language: Английский

Citations

0