Lactobacillus plantarum 17-1 Ameliorates DSS-Induced Colitis by Modulating the Colonic Microbiota Composition and Metabolome in Mice DOI Open Access
Beibei He, Tao Duan, Dandan Hu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1348 - 1348

Published: April 15, 2025

Background/Objectives: Lactobacillus strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). However, strain specificity limited stress resistance of restricts its therapeutic effectiveness. The aim this study was to investigate effects dietary supplementation with microencapsulated plantarum 17-1 on intestinal immune responses, gut microbiota composition, metabolic characteristics colitis mice. Methods: Mice were pre-fed a diet containing 3 weeks then treated 2.5% dextran sulfate sodium (DSS) drinking water 8 days induce colitis. Results: results showed that effectively alleviated clinical symptoms histopathological features mice suppressed up-regulation pro-inflammatory cytokines IL-6 IL-17 colon Additionally, significantly increased relative abundance several beneficial bacterial taxa, including Ruminococcaceae_UCG_014, Bacteroides, Prevotellaceae_UCG_001, Lactococcus, Weissella, Pediococcus, so on. Moreover, it regulated levels multiple inflammation-related metabolites involved linolenic acid metabolism, arachidonic primary bile biosynthesis, tyrosine metabolism. Conclusions: These suggest reduced inflammation by modulating composition characteristics, which may serve strategy IBD.

Language: Английский

Lactobacillus plantarum 17-1 Ameliorates DSS-Induced Colitis by Modulating the Colonic Microbiota Composition and Metabolome in Mice DOI Open Access
Beibei He, Tao Duan, Dandan Hu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1348 - 1348

Published: April 15, 2025

Background/Objectives: Lactobacillus strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). However, strain specificity limited stress resistance of restricts its therapeutic effectiveness. The aim this study was to investigate effects dietary supplementation with microencapsulated plantarum 17-1 on intestinal immune responses, gut microbiota composition, metabolic characteristics colitis mice. Methods: Mice were pre-fed a diet containing 3 weeks then treated 2.5% dextran sulfate sodium (DSS) drinking water 8 days induce colitis. Results: results showed that effectively alleviated clinical symptoms histopathological features mice suppressed up-regulation pro-inflammatory cytokines IL-6 IL-17 colon Additionally, significantly increased relative abundance several beneficial bacterial taxa, including Ruminococcaceae_UCG_014, Bacteroides, Prevotellaceae_UCG_001, Lactococcus, Weissella, Pediococcus, so on. Moreover, it regulated levels multiple inflammation-related metabolites involved linolenic acid metabolism, arachidonic primary bile biosynthesis, tyrosine metabolism. Conclusions: These suggest reduced inflammation by modulating composition characteristics, which may serve strategy IBD.

Language: Английский

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