Harnessing Dendritic Cell Function in Hepatocellular Carcinoma: Advances in Immunotherapy and Therapeutic Strategies DOI Creative Commons

Shuxuan Ying,

Haiyan Liu, Yongliang Zhang

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(5), P. 496 - 496

Published: May 4, 2025

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. Conventional therapies are frequently limited by tumor heterogeneity and the immunosuppressive microenvironment (TME). Dendritic cells (DCs), central to orchestrating antitumor immunity, have become key targets for HCC immunotherapy. This review examines biological functions DC subsets (cDC1, cDC2, pDC, moDC) their roles in initiating modulating immune responses against HCC. We detail mechanisms underlying impairment within TME, including suppression regulatory T (Tregs), myeloid-derived suppressor (MDSCs), tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs). Additionally, we discuss novel DC-based therapeutic strategies, such as vaccines designed enhance antigen presentation cell activation. Combining with checkpoint inhibitors (ICIs), PD-1/PD-L1 CTLA-4 blockers, demonstrates synergistic effects that can overcome evasion improve clinical outcomes. Despite progress, challenges related subset heterogeneity, TME complexity, patient variability require further optimization personalization therapies. Future research should focus on refining these leveraging advanced technologies like genomic profiling artificial intelligence, maximize efficacy revolutionize treatment. By restoring function reprogramming immunotherapy holds immense potential transform management survival.

Language: Английский

Exploration of the role of immune cells and cell therapy in hepatocellular carcinoma DOI Creative Commons
Tao Zhang, Chongyang Ren, Zhanyu Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Hepatocellular carcinoma stands as one of the foremost contributors to cancer-associated fatalities globally, and limitations traditional treatment methods have prompted researchers explore new therapeutic options. Recently, cell therapy has emerged a promising approach for HCC, showing significant potential in improving patient outcomes. This review article explores use covering different types, mechanisms behind their effectiveness, recent advancements clinical trials, ongoing challenges. aims provide insightful perspectives future research applications treating HCC by synthesizing current knowledge.

Language: Английский

Citations

0
Harnessing Dendritic Cell Function in Hepatocellular Carcinoma: Advances in Immunotherapy and Therapeutic Strategies DOI Creative Commons

Shuxuan Ying,

Haiyan Liu, Yongliang Zhang

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(5), P. 496 - 496

Published: May 4, 2025

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. Conventional therapies are frequently limited by tumor heterogeneity and the immunosuppressive microenvironment (TME). Dendritic cells (DCs), central to orchestrating antitumor immunity, have become key targets for HCC immunotherapy. This review examines biological functions DC subsets (cDC1, cDC2, pDC, moDC) their roles in initiating modulating immune responses against HCC. We detail mechanisms underlying impairment within TME, including suppression regulatory T (Tregs), myeloid-derived suppressor (MDSCs), tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs). Additionally, we discuss novel DC-based therapeutic strategies, such as vaccines designed enhance antigen presentation cell activation. Combining with checkpoint inhibitors (ICIs), PD-1/PD-L1 CTLA-4 blockers, demonstrates synergistic effects that can overcome evasion improve clinical outcomes. Despite progress, challenges related subset heterogeneity, TME complexity, patient variability require further optimization personalization therapies. Future research should focus on refining these leveraging advanced technologies like genomic profiling artificial intelligence, maximize efficacy revolutionize treatment. By restoring function reprogramming immunotherapy holds immense potential transform management survival.

Language: Английский

Citations

0