Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer DOI Creative Commons
Wei Zhang, Yongmin Liu, Dong Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Cervical cancer is a common malignant tumor in women, and human papillomavirus (HPV) infection major cause of cervical cancer. Tumor-infiltrating lymphocytes (TILs) are heterogeneous group primarily composed T found within the parenchyma stroma. These cells can be isolated from tissue, activated, expanded vitro , reinfused into patient to exert an anti-tumor immune effect. As form personalized immunotherapy, TILs therapy has shown satisfactory efficacy safety advanced recurrent metastatic cancer, offering new hope patients with However, for still faces several limitations challenges. This article reviews process latest developments discusses challenges usage prospects this treatment.

Language: Английский

Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy DOI Creative Commons
Yibo He, Qianran Hong, Shiliang Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Gastric cancer (GC) remains a significant global health concern due to its poor prognosis and limited therapeutic options, particularly in advanced stages. Tumor microenvironment (TME), tumor-associated macrophages (TAMs), plays key role tumor progression, immune evasion, therapy resistance. TAMs exhibit plasticity, shifting between pro-inflammatory M1 immunosuppressive M2 phenotypes, with the latter predominating GC contributing outcomes. Recent advancements focus on targeting TAMs, including inhibiting polarization, reprogramming combining TAM-targeted approaches checkpoint inhibitors. Innovations nanotechnology, metabolic reprogramming, pathways such as interleukin-6 C-C motif ligand 2/C-C chemokine receptor 2 further enhance these strategies. However, challenges remain, spatial functional heterogeneity of within TME need for selective avoid disrupting homeostasis. Ongoing research TAM origins, functions, interactions is crucial developing precise effective therapies. These advances hold promise not only improving outcomes but also addressing other cancers similarly complex microenvironments.

Language: Английский

Citations

1
The role of macrophages in liver metastasis: mechanisms and therapeutic prospects DOI Creative Commons
Qin Yuan,

Linlin Jia,

Jiahua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Metastasis is a hallmark of advanced cancer, and the liver common site for secondary metastasis many tumor cells, including colorectal, pancreatic, gastric, prostate cancers. Macrophages in microenvironment (TME) promote cell through various mechanisms, angiogenesis immunosuppression, play unique role development metastasis. are affected by variety factors. Under conditions hypoxia increased acidity TME, more factors now found to polarization macrophages M2 type, exosomes amino acids. M2-type secretion such as VEGF, IL-1β, TGF-β1. subjected multiple regulatory mechanisms. They also interact with cells within co-regulate certain conditions, creation an immunosuppressive microenvironment. This interaction promotes metastasis, drug resistance, immune escape. Based on advent single-cell sequencing technology, further insights into macrophage subpopulations may help exploring new therapeutic targets future. In this paper, we will focus how affect well other each other, investigate mechanisms involved their potential targets.

Language: Английский

Citations

0
Smart materials in pharmacological drug development: Neutrophils and its constituents for drug delivery and consequent antitumor effects DOI

Shengjie Cai,

Xuehan Wei,

Qian Li

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 183, P. 18 - 32

Published: May 2, 2025

Language: Английский

Citations

0
Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer DOI Creative Commons
Wei Zhang, Yongmin Liu, Dong Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Cervical cancer is a common malignant tumor in women, and human papillomavirus (HPV) infection major cause of cervical cancer. Tumor-infiltrating lymphocytes (TILs) are heterogeneous group primarily composed T found within the parenchyma stroma. These cells can be isolated from tissue, activated, expanded vitro , reinfused into patient to exert an anti-tumor immune effect. As form personalized immunotherapy, TILs therapy has shown satisfactory efficacy safety advanced recurrent metastatic cancer, offering new hope patients with However, for still faces several limitations challenges. This article reviews process latest developments discusses challenges usage prospects this treatment.

Language: Английский

Citations

0