Optimizing viral transduction in immune cell therapy manufacturing: key process design considerations DOI Creative Commons

Liu Dan,

Lee Kang-Zheng

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 2, 2025

Immune cell therapies have revolutionized the treatment of cancers, autoimmune disorders, and infectious diseases. A critical step in their manufacturing is viral transduction, which enables delivery therapeutic genes into immune cells. However, complexity this process presents significant challenges for optimization scalability. This review provides a comprehensive analysis transduction therapy manufacturing, highlighting key design considerations to support development safe, effective, scalable production methods. Additionally, it examines current technological explores future innovations poised advance field.

Language: Английский

Optimizing viral transduction in immune cell therapy manufacturing: key process design considerations DOI Creative Commons

Liu Dan,

Lee Kang-Zheng

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 2, 2025

Immune cell therapies have revolutionized the treatment of cancers, autoimmune disorders, and infectious diseases. A critical step in their manufacturing is viral transduction, which enables delivery therapeutic genes into immune cells. However, complexity this process presents significant challenges for optimization scalability. This review provides a comprehensive analysis transduction therapy manufacturing, highlighting key design considerations to support development safe, effective, scalable production methods. Additionally, it examines current technological explores future innovations poised advance field.

Language: Английский

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