Next‐Generation Flexible Embolic Systems: Targeted Transarterial Chemoembolization Strategies for Hepatocellular Carcinoma DOI
Han Wu,

Shao-Dong Lv,

Renjie Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Transarterial chemoembolization (TACE) remains the gold standard for treating intermediate‐stage hepatocellular carcinoma (HCC), yet faces great challenges in overcoming tumor heterogeneity, hypoxia‐induced angiogenesis, and metastatic progression. The development of advanced flexible embolization materials marks a revolutionary leap interventional therapy, offering opportunities to revolutionize precision, drug delivery kinetics, microenvironment modulation. This comprehensive review systematically examines paradigm shift toward next‐generation TACE technology, emphasizing limitations conventional approaches innovations embolic agents. A detailed discussion nano‐flexible systems is presented, their unique coagulation dynamics, real‐time imaging capabilities, therapeutic precision. delves into groundbreaking strategies integrating hypoxia modulation, energy conversion therapeutics, sophisticated engineering. Clinical translation aspects are thoroughly explored, including large‐scale trial outcomes, vascular recanalization patient‐specific treatment optimization. Looking forward, key frontiers field identified: intelligent nanocomposite systems, synergistic combination therapies, precision medicine tailored individual biology. work not only objectively evaluates current progress but also charts future research priorities, aiming transform from palliative intervention platform ultimately reshaping landscape HCC patient care.

Language: Английский

Next‐Generation Flexible Embolic Systems: Targeted Transarterial Chemoembolization Strategies for Hepatocellular Carcinoma DOI
Han Wu,

Shao-Dong Lv,

Renjie Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Transarterial chemoembolization (TACE) remains the gold standard for treating intermediate‐stage hepatocellular carcinoma (HCC), yet faces great challenges in overcoming tumor heterogeneity, hypoxia‐induced angiogenesis, and metastatic progression. The development of advanced flexible embolization materials marks a revolutionary leap interventional therapy, offering opportunities to revolutionize precision, drug delivery kinetics, microenvironment modulation. This comprehensive review systematically examines paradigm shift toward next‐generation TACE technology, emphasizing limitations conventional approaches innovations embolic agents. A detailed discussion nano‐flexible systems is presented, their unique coagulation dynamics, real‐time imaging capabilities, therapeutic precision. delves into groundbreaking strategies integrating hypoxia modulation, energy conversion therapeutics, sophisticated engineering. Clinical translation aspects are thoroughly explored, including large‐scale trial outcomes, vascular recanalization patient‐specific treatment optimization. Looking forward, key frontiers field identified: intelligent nanocomposite systems, synergistic combination therapies, precision medicine tailored individual biology. work not only objectively evaluates current progress but also charts future research priorities, aiming transform from palliative intervention platform ultimately reshaping landscape HCC patient care.

Language: Английский

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