Chromone-Based Copper(II) Complexes as Potential Antitumour Agents: Synthesis, Chemical Characterisation and In Vitro Biological Evaluation DOI Creative Commons
Nikolina Filipović, Tomislav Balić, Martina Medvidović‐Kosanović

et al.

Crystals, Journal Year: 2025, Volume and Issue: 15(5), P. 389 - 389

Published: April 23, 2025

Three new complexes of copper(II) and chromone-2-carboxylic acid, a ligand from the group hydroxypyrones, were synthesised according to principles green chemistry. The characterised by FT–IR NMR spectroscopy, thermal electrochemical analysis, their structures are proposed. results show formation mononuclear (1) dinuclear hydroxo-bridged (2 3). cyclic voltammetry that copper in all is +2-oxidation state. antiproliferative activity was determined MTT assay on 2D cell models vitro seven lines. spectrum 1–3 ranged highest lowest value tumour lines tested, following order: Hep G2 > NCI-H358 HT-29 KATO III MDA-MB 231 Caco-2. most effective concentration 10−5 mol dm−3, which suppressed growth cells as follows: 69.5% (1), 64.8% (2) 64% (3). calculated selectivity index clearly shows sensitive line (SI = 1.623 (1); 1.557 (2), 1.431

Language: Английский

Copper in melanoma: at the crossroad of protumorigenic and anticancer roles DOI Creative Commons

Natalia Chrzan,

Mariusz L. Hartman

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103552 - 103552

Published: Feb. 15, 2025

Language: Английский

Citations

0
Integrating cuproptosis and immunosenescence: A novel therapeutic strategy in cancer treatment DOI
Ali Ahmadizad Firouzjaei, Seyed Hamid Aghaee‐Bakhtiari

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 42, P. 101983 - 101983

Published: March 29, 2025

Language: Английский

Citations

0
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis DOI Creative Commons
Haotian Xu,

Qingyun Zhao,

Dunyu Cai

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: April 2, 2025

Abstract Background Lung cancer is a serious threat to human life and health, but effective screening treatment methods are lacking. Circular RNAs (circRNAs) have important biological functions closely related tumour development. Some studies shown that the 8-oxo-7,8-dihydroguanosine (o8G) modification plays key role in disease process, effect of o8G on circRNAs has not been elucidated. Moreover, cuproptosis novel mode cell death which copper ions directly promote protein aggregation disruption cellular metabolic pathways. The present study revealed circKIAA1797 occurs promotes lung development by inhibiting cuproptosis, provides new perspectives for epitranscriptomic therapeutic approaches cancer. Methods circRNA differential expression profiles were via RNA high-throughput sequencing, lines tissues was detected using qPCR. Experiments such as immunoprecipitation (o8G RIP) crosslinking (CLIP) performed explore presence circKIAA1797. regulation reader Y-box binding 1 (YBX1) explored nuclear–cytoplasmic fractionation, actinomycin D (Act D) stability experiments other experiments. silencing overexpression systems constructed vivo vitro Tagged affinity purification (TRAP), (RIP), coimmunoprecipitation (Co-IP), immunofluorescence (IF) staining subsequently conducted reveal molecular mechanism regulates Results This first YBX1 recognises ROS-induced modifications increases cytoplasmic circKIAA1797, associated with stage prognosis, significantly function both vitro. inhibits intracellular ferredoxin (FDX1) mRNA, decreasing FDX1 mRNA stability, expression, signal transducer activator transcription (STAT1) lipoyltransferase (LIPT1) transcription; moreover, closure mitochondrial permeability transition pore (mPTP), ultimately Conclusions an can inhibit proteins promoting mPTP closure, only theoretical basis in-depth understanding mechanisms also potential target treatment.

Language: Английский

Citations

0
Multi-pathway copper metabolisms regulation based on an engineered copper/ferrous nanoplatform for enhanced tumor cuproptosis therapy DOI

Yun Gao,

Renlu Han, Zhen Guo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114682 - 114682

Published: April 1, 2025

Language: Английский

Citations

0
Chromone-Based Copper(II) Complexes as Potential Antitumour Agents: Synthesis, Chemical Characterisation and In Vitro Biological Evaluation DOI Creative Commons
Nikolina Filipović, Tomislav Balić, Martina Medvidović‐Kosanović

et al.

Crystals, Journal Year: 2025, Volume and Issue: 15(5), P. 389 - 389

Published: April 23, 2025

Three new complexes of copper(II) and chromone-2-carboxylic acid, a ligand from the group hydroxypyrones, were synthesised according to principles green chemistry. The characterised by FT–IR NMR spectroscopy, thermal electrochemical analysis, their structures are proposed. results show formation mononuclear (1) dinuclear hydroxo-bridged (2 3). cyclic voltammetry that copper in all is +2-oxidation state. antiproliferative activity was determined MTT assay on 2D cell models vitro seven lines. spectrum 1–3 ranged highest lowest value tumour lines tested, following order: Hep G2 > NCI-H358 HT-29 KATO III MDA-MB 231 Caco-2. most effective concentration 10−5 mol dm−3, which suppressed growth cells as follows: 69.5% (1), 64.8% (2) 64% (3). calculated selectivity index clearly shows sensitive line (SI = 1.623 (1); 1.557 (2), 1.431

Language: Английский

Citations

0