Linking microbial communities to rheumatoid arthritis: focus on gut, oral microbiome and their extracellular vesicles DOI Creative Commons

Jian Lü,

Yi Wang,

Jing Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Rheumatoid arthritis (RA) is a severe, chronic autoimmune disease affecting approximately 1% of the global population. Research has demonstrated that microorganisms play crucial role in onset and progression RA. This indicates disruption immune homeostasis may originate from mucosal sites, such as gut oral cavity. In intestines patients preclinical stage RA, an increased abundance Prevotella species with strong association to was observed. cavity, infections by Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans can mediate production anti-citrullinated protein antibodies (ACPAs), potentially contributing RA pathogenesis. Nevertheless, no single bacterial been consistently identified primary driver review will discuss connection between bacteria development arthritis. Additionally, it explores extracellular vesicles (bEVs) inducing inflammation their potential pathogenic roles

Language: Английский

Linking microbial communities to rheumatoid arthritis: focus on gut, oral microbiome and their extracellular vesicles DOI Creative Commons

Jian Lü,

Yi Wang,

Jing Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Rheumatoid arthritis (RA) is a severe, chronic autoimmune disease affecting approximately 1% of the global population. Research has demonstrated that microorganisms play crucial role in onset and progression RA. This indicates disruption immune homeostasis may originate from mucosal sites, such as gut oral cavity. In intestines patients preclinical stage RA, an increased abundance Prevotella species with strong association to was observed. cavity, infections by Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans can mediate production anti-citrullinated protein antibodies (ACPAs), potentially contributing RA pathogenesis. Nevertheless, no single bacterial been consistently identified primary driver review will discuss connection between bacteria development arthritis. Additionally, it explores extracellular vesicles (bEVs) inducing inflammation their potential pathogenic roles

Language: Английский

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