Urinary and Plasma miRNAs in the Early Detection of Acute Kidney Injury and Their Possible Role as Therapeutic Targets DOI Open Access
Anna Clementi,

Grazia Maria Virzì,

Claudio Ronco

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2306 - 2306

Published: March 28, 2025

Acute Kidney Injury (AKI) is a severe clinical condition featured by rapid decrease in kidney function short period of time. AKI, which often secondary to sepsis, ischemia-reperfusion and drug toxicity, associated high morbidity mortality. Moreover, it contributes the development chronic disease (CKD), due maladaptive or incomplete repair mechanisms, resulting renal fibrosis. Small non-coding RNA has recently emerged as novel biomarker for early detection treatment AKI. In particular, microRNAs (miRNAs) are molecules 21-25 nucleotides regulating expression protein-coding genes through sequence-specific recognition. Due their stability biological fluids, such urine plasma, they can be reliably analyzed quantified, this reason considered potential diagnostic therapeutic biomarkers. Specifically, miRNAs have been demonstrated predict AKI before increase creatinine levels, thus improving management syndrome. review, we provide comprehensive overview role urinary plasma

Language: Английский

Urinary and Plasma miRNAs in the Early Detection of Acute Kidney Injury and Their Possible Role as Therapeutic Targets DOI Open Access
Anna Clementi,

Grazia Maria Virzì,

Claudio Ronco

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2306 - 2306

Published: March 28, 2025

Acute Kidney Injury (AKI) is a severe clinical condition featured by rapid decrease in kidney function short period of time. AKI, which often secondary to sepsis, ischemia-reperfusion and drug toxicity, associated high morbidity mortality. Moreover, it contributes the development chronic disease (CKD), due maladaptive or incomplete repair mechanisms, resulting renal fibrosis. Small non-coding RNA has recently emerged as novel biomarker for early detection treatment AKI. In particular, microRNAs (miRNAs) are molecules 21-25 nucleotides regulating expression protein-coding genes through sequence-specific recognition. Due their stability biological fluids, such urine plasma, they can be reliably analyzed quantified, this reason considered potential diagnostic therapeutic biomarkers. Specifically, miRNAs have been demonstrated predict AKI before increase creatinine levels, thus improving management syndrome. review, we provide comprehensive overview role urinary plasma

Language: Английский

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