Habitat radiomics predicts occult lymph node metastasis and uncovers immune microenvironment of head and neck cancer

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 1, 2025

Occult lymph node metastasis (LNM) is a key prognostic factor for patients with head and neck squamous cell carcinoma (HNSCC). This study was to establish radiomics models derived from intratumoral, peritumoral, habitat regions identifying occult LNM in HNSCC. Patients pathologically confirmed HNSCC three medical Centers (from March 2014 April 2024) The Cancer Genome Atlas (TCGA) were enrolled. Center 1 split into training (n = 330) internal test sets 154), while 2 3 served as the external set 183). Genomic 50) TCGA single-cell RNA sequencing 6) used biological analysis. We volumes of interest (VOIs) extract features, respectively. Based on Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF) classifiers, nine built confirm optimal predictive performance. best-performing model, along clinical-radiologic data, combined develop hybrid model. log-rank evaluate model's Additionally, bulk applied investigating mechanisms underlying RF-habitat model showed best performance, achieving AUCs 0.835-0.919 across all datasets. Survival analysis further value notably surpassed clinical Moreover, associated abundance level exhaustion-associated CD8 + T cells, uncovering immune microenvironment characteristics contributing demonstrated excellent performance predicting cohorts, providing non-invasive solution LNM. Furthermore, radiogenomic revealed associations primarily related dysfunction.

Language: Английский

---

Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Cancer immunotherapy, which leverages the immune system to target neoplastic cells, has undergone significant transformation in recent. However, immunotherapy may have negative effects on skeletal muscle function, causing wasting and functional decline cancer patients. In this study, we review mechanisms by influences muscle, focusing immune-related myositis, inflammation, metabolic alterations within tumor microenvironment (TME). The key methodologies, including biomechanical assessment techniques such as electrical impedance myography ultrasound imaging, are discussed provide valuable insights into process that maintain integrity function patients receiving immunotherapy. Moreover, dual of suppression damage described, revealing significance inflammatory cytokines, checkpoints, disturbances TME. Importantly, propose combination therapies integrating nutritional interventions or anti-inflammatory potential approaches for mitigating wasting. This study highlights need deeper investigations optimize improve its efficacy preserving health, thereby improving patient outcomes quality life.

Language: Английский

---

Development and validation of a machine learning model based on complete blood counts to predict clinical outcomes in urothelial carcinoma patients

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120367 - 120367

Published: May 1, 2025

Language: Английский

---

A review of the role of CSCs and CSC-EXOs in increasing drug resistance in breast cancer and future applications

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104774 - 104774

Published: May 1, 2025

Language: Английский

---