The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction DOI Creative Commons
Lujian Zhu,

Minli Hu,

Haoming Xu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Pyroptosis is an inflammatory form of cell death involving caspase-1 or caspase-4/5/11, initiated by inflammasomes cytoplasmic endotoxins as part the immune defense. It specifically characterized Gasdermin-mediated pore formation leading to lysis, pyroptosis also entails release pro-inflammatory cytokines. As a natural mechanism system, it activates in response harmful stimuli eliminate threats and facilitate tissue repair. However, excessive can lead detrimental outcomes, such infectious shock, multiple organ dysfunction syndrome (MODS), increased susceptibility secondary infections. Sepsis, unchecked infection, remains cause MODS among critically ill patients. The pathogenesis sepsis complex multifaceted, innate inflammation that kills infected cells releases Recent research has increasingly explored link between sepsis, focusing on its mechanisms, roles, potential therapeutic targets. There been significant advancement understanding pyroptosis, highlighting vital role development sepsis. This review delves into molecular pathophysiological roles with particular emphasis impact specific organs heart, lungs, liver, kidney brain, aiming identify new diagnostic markers targets for management.

Language: Английский

The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction DOI Creative Commons
Lujian Zhu,

Minli Hu,

Haoming Xu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Pyroptosis is an inflammatory form of cell death involving caspase-1 or caspase-4/5/11, initiated by inflammasomes cytoplasmic endotoxins as part the immune defense. It specifically characterized Gasdermin-mediated pore formation leading to lysis, pyroptosis also entails release pro-inflammatory cytokines. As a natural mechanism system, it activates in response harmful stimuli eliminate threats and facilitate tissue repair. However, excessive can lead detrimental outcomes, such infectious shock, multiple organ dysfunction syndrome (MODS), increased susceptibility secondary infections. Sepsis, unchecked infection, remains cause MODS among critically ill patients. The pathogenesis sepsis complex multifaceted, innate inflammation that kills infected cells releases Recent research has increasingly explored link between sepsis, focusing on its mechanisms, roles, potential therapeutic targets. There been significant advancement understanding pyroptosis, highlighting vital role development sepsis. This review delves into molecular pathophysiological roles with particular emphasis impact specific organs heart, lungs, liver, kidney brain, aiming identify new diagnostic markers targets for management.

Language: Английский

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