Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells DOI Open Access

Jung-Eun Lee,

Ju‐Hyun Lee, Jung‐Min Koh

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5866 - 5866

Published: May 28, 2024

Dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) has been found to be beneficial in rodent rheumatoid arthritis models and human trials. However, the molecular targets of PUFAs their effects on are under-researched. Free acid receptor 4 (FFA4, also known as GPR120) is a for PUFA. We aim investigate whether FFA4 activation reduces collagen-induced (CIA) by using an agonist, compound A (CpdA), combination DBA-1J Ffa4 gene wild-type (WT) knock-out (KO) mice. CIA induced increase score, foot edema, synovial hyperplasia, pannus formation, proteoglycan loss, cartilage damage, bone erosion, whereas administration CpdA significantly suppressed those increases WT mice but not KO increased mRNA expression levels pro-inflammatory Th1/Th17 cytokines, imbalance between Treg cells, rebalanced them spleens from In SW982 reduced LPS-induced cytokine levels. summary, present results suggest that immune cells could suppress characteristics adjuvant therapy.

Language: Английский

HDAC1 Promotes Hippocampal Neuronal Pyroptosis in Epileptic Mice Through the miR-15a-5p/Caspase-1 Axis DOI

Yun Lv,

Fenghua Sun,

Binyu Pu

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: March 25, 2025

Language: Английский

Citations

0
GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy DOI Creative Commons
Aolei Lin, Yi Guo, Hui Zhang

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(5), P. 166687 - 166687

Published: March 14, 2023

Language: Английский

Citations

8
Safranal alleviates pentetrazole-induced epileptic seizures in mice by inhibiting the NF-κB signaling pathway and mitochondrial-dependent apoptosis through GSK-3β inactivation DOI Creative Commons
Jieping Yan, Tingting Li,

Kaiyue Ji

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118408 - 118408

Published: May 31, 2024

Saffron, a traditional Chinese medicine, is derived from Crocus sativus L. stigmas and has been reported to possess neuroprotective properties potentially contribute the inhibition of apoptosis inflammation. Safranal, potent monothyral aldehyde, main component saffron that have antiepileptic activity. However, specific mechanism by which safranal suppresses epileptic seizures via its antiapoptotic anti-inflammatory unclear.

Language: Английский

Citations

3
The inhibition of PGAM5 suppresses seizures in a kainate-induced epilepsy model via mitophagy reduction DOI Creative Commons
Fuxin Zhong, Yunhao Gan, Jiaqi Song

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: Dec. 22, 2022

Epilepsy is a common neurological disease, and excessive mitophagy considered as one of the major triggers epilepsy. Mitophagy crucial pathway affecting reactive oxygen species. Phosphoglycerate mutase 5 (PGAM5) protein phosphatase present in mitochondria that regulates many biological processes including cell death. However, mechanism PGAM5 epilepsy remains unclear. The purpose study was to examine whether affects through PTEN-induced putative kinase 1 (PINK1)-mediated mitophagy. After knockdown expression by adeno-associated virus, an model created kainic acid. Next, seizure activity recorded local field potentials before evaluating level mitochondrial autophagy marker proteins. Lastly, ultrastructure mitochondria, neuronal damage oxidative stress levels were further observed. A higher found epilepsy, its cellular localization neurons. interactions between PINK1 found. PGAM5, light chain 3B decreased translocase inner membrane 23 outer 20 both increased. Knockdown also resulted reduced damage, malondialdehyde levels, species production increased superoxide dismutase activity. In addition, duration spontaneous seizure-like events (SLEs), number SLEs time spent all after inhibition expression. Inhibition reduces seizures via inhibiting PINK1-mediated

Language: Английский

Citations

13
Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells DOI Open Access

Jung-Eun Lee,

Ju‐Hyun Lee, Jung‐Min Koh

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5866 - 5866

Published: May 28, 2024

Dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) has been found to be beneficial in rodent rheumatoid arthritis models and human trials. However, the molecular targets of PUFAs their effects on are under-researched. Free acid receptor 4 (FFA4, also known as GPR120) is a for PUFA. We aim investigate whether FFA4 activation reduces collagen-induced (CIA) by using an agonist, compound A (CpdA), combination DBA-1J Ffa4 gene wild-type (WT) knock-out (KO) mice. CIA induced increase score, foot edema, synovial hyperplasia, pannus formation, proteoglycan loss, cartilage damage, bone erosion, whereas administration CpdA significantly suppressed those increases WT mice but not KO increased mRNA expression levels pro-inflammatory Th1/Th17 cytokines, imbalance between Treg cells, rebalanced them spleens from In SW982 reduced LPS-induced cytokine levels. summary, present results suggest that immune cells could suppress characteristics adjuvant therapy.

Language: Английский

Citations

2