Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: Dec. 19, 2023
Copper
(Cu)
plays
a
crucial
role
as
trace
element
in
various
physiological
processes
humans.
Nonetheless,
free
copper
ions
accumulate
the
brain
over
time,
resulting
range
of
pathological
changes.
Compelling
evidence
indicates
that
excessive
deposition
contributes
to
cognitive
decline
individuals
with
Alzheimer’s
disease
(AD).
Free
levels
serum
and
AD
patients
are
notably
elevated,
leading
reduced
antioxidant
defenses
mitochondrial
dysfunction.
Moreover,
accumulation
triggers
specific
form
cell
death,
namely
copper-dependent
death
(cuproptosis).
This
article
aimed
review
correlation
between
dysregulation
pathogenesis
AD,
along
primary
pathways
regulating
homoeostasis
copper-induced
AD.
Additionally,
efficacy
safety
natural
synthetic
agents,
including
chelators,
lipid
peroxidation
inhibitors,
antioxidants,
were
examined.
These
treatments
can
restore
equilibrium
prevent
cases.
Another
aim
this
was
highlight
significance
promote
development
pharmaceutical
interventions
address
it.
Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(4)
Published: Feb. 14, 2024
The
rediscovery
of
meningeal
lymphatic
vessels
(MLVs)
has
sparked
research
interest
in
their
function
numerous
neurological
pathologies.
Craniosynostosis
(CS)
is
caused
by
a
premature
fusion
cranial
sutures
during
development.
In
this
issue
the
JCI,
Matrongolo
and
colleagues
show
that
Twist1-haploinsufficient
mice
develop
CS
exhibit
raised
intracranial
pressure,
diminished
cerebrospinal
fluid
(CSF)
outflow,
impaired
paravascular
CSF-brain
flow;
all
features
were
associated
with
MLV
defects
exacerbated
pathology
mouse
models
Alzheimer's
disease.
Activation
mechanosensor
Piezo1
Yoda1
restored
CSF
perfusion
aged
mice,
opening
an
avenue
for
further
development
therapeutics.
Particle and Fibre Toxicology,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Feb. 15, 2024
Abstract
Background
Air
pollution
is
recognized
as
an
emerging
environmental
risk
factor
for
neurological
diseases.
Large-scale
epidemiological
studies
associate
traffic-related
particulate
matter
(PM)
with
impaired
cognitive
functions
and
increased
incidence
of
neurodegenerative
diseases
such
Alzheimer’s
disease.
Inhaled
components
PM
may
directly
invade
the
brain
via
olfactory
route,
or
act
through
peripheral
system
responses
resulting
in
inflammation
oxidative
stress
brain.
Microglia
are
immune
cells
implicated
progression
However,
it
remains
unknown
how
affects
live
human
microglia.
Results
Here
we
show
that
two
different
PMs
derived
from
exhausts
cars
running
on
EN590
diesel
compressed
natural
gas
(CNG)
alter
function
microglia-like
vitro.
We
exposed
induced
pluripotent
stem
cell
(iPSC)-derived
(iMGLs)
to
traffic
related
explored
their
functional
responses.
Lower
concentrations
ranging
between
10
100
µg
ml
−1
microglial
survival
whereas
higher
became
toxic
over
time.
Both
tested
pollutants
phagocytosis
secretion
a
few
proinflammatory
cytokines
distinct
patterns,
compared
lipopolysaccharide
iMGLs
showed
pollutant
dependent
production
reactive
oxygen
species
(ROS)
CNG
inducing
reducing
ROS
production.
Conclusions
Our
study
indicates
air
microglia
warrant
further
determine
whether
these
changes
contribute
adverse
effects
cognition
This
demonstrates
iPSC-microglia
valuable
tool
agents.
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: Dec. 19, 2023
Copper
(Cu)
plays
a
crucial
role
as
trace
element
in
various
physiological
processes
humans.
Nonetheless,
free
copper
ions
accumulate
the
brain
over
time,
resulting
range
of
pathological
changes.
Compelling
evidence
indicates
that
excessive
deposition
contributes
to
cognitive
decline
individuals
with
Alzheimer’s
disease
(AD).
Free
levels
serum
and
AD
patients
are
notably
elevated,
leading
reduced
antioxidant
defenses
mitochondrial
dysfunction.
Moreover,
accumulation
triggers
specific
form
cell
death,
namely
copper-dependent
death
(cuproptosis).
This
article
aimed
review
correlation
between
dysregulation
pathogenesis
AD,
along
primary
pathways
regulating
homoeostasis
copper-induced
AD.
Additionally,
efficacy
safety
natural
synthetic
agents,
including
chelators,
lipid
peroxidation
inhibitors,
antioxidants,
were
examined.
These
treatments
can
restore
equilibrium
prevent
cases.
Another
aim
this
was
highlight
significance
promote
development
pharmaceutical
interventions
address
it.
