Parkinson’s disease models and death signaling: what do we know until now? DOI Creative Commons

Luiz Fernando A. T. Pedrão,

Pâmela Medeiros,

Estela C. Leandro

et al.

Frontiers in Neuroanatomy, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 29, 2024

Parkinson's disease (PD) is the second neurodegenerative disorder most prevalent in world, characterized by loss of dopaminergic neurons Substantia Nigra (SN). It well known for its motor and non-motor symptoms including bradykinesia, resting tremor, psychiatric, cardiorespiratory, other dysfunctions. Pathological apoptosis contributes to a wide variety diseases PD. Various insults and/or cellular phenotypes have been shown trigger distinct signaling events leading cell death affected The intrinsic or mitochondrial pathway, inflammatory oxidative stress-induced extrinsic pathways are main associated with PD-related neuronal loss. Although SN brain area studied so far, nuclei also non-classical as symptoms. Among these, respiratory often overlooked, yet they can cause discomfort may contribute patients shortened lifespan after diagnosis. While animal

Language: Английский

Targeting Lkb1-Ampk-Sirt1-Induced Autophagy and Mitophagy Pathways Improve Cerebrovascular Homeostasis in App/Ps1 Mice DOI
Yawen Li, Yifan Wu, Tongxing Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The role of cannabinoid-mediated signaling pathways and mechanisms in brain disorders DOI
Shunfeng Liu, Zegang Ma

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111653 - 111653

Published: Feb. 1, 2025

Language: Английский

Citations

0
Astrocytes-associated research in Parkinson’s disease: an explored trends analysis DOI Creative Commons
Yan-Jun Chen,

Ming-Rong Xie,

Shengqiang Zhou

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 27, 2025

Background Parkinson’s disease (PD) is characterized pathologically by the degeneration of dopaminergic neurons and formation Lewy bodies. Among various cellular molecular mechanisms PD, astrocyte dysfunction one causes development. This study aims to explore research hotspots, frontiers, prospective directions regarding PD astrocytes. Method Relevant academic publications were searched through Web Science database. CiteSpace, VOSviewer, bibliometrix used for visualization quantitative evaluation. Results A total 2,408 related topic included in analysis. From 2001 2024, annual gradually increased. Activated countries concentrated North America, Asia, Europe. The United States China main leaders. Nanjing Medical University was active institution with largest number publications, Cambridge had highest influence on publications. International Journal Molecular Sciences core journal most Dr. Hu, Gang productive author, Saarma, Mart influential author. Research hotspots astrocytes, neuroinflammation, alpha-synuclein (α-Syn), microglia, oxidative stress, neurodegeneration. In recent years, NLRP3 inflammasome, extracellular vesicles (EVs), signaling pathway topics strong burst power. Conclusion Collaboration among different countries, organizations, authors has effectively promoted rapid development this field, achievements have mainly focused α-Syn, EVs, are future.

Language: Английский

Citations

0
Targeting LKB1–AMPK–SIRT1–induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice DOI
Yawen Li, Tongxing Wang, Hong-Rong Li

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring DOI
Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 301 - 316

Published: April 10, 2024

Language: Английский

Citations

3
Identification of key genes and signaling pathway in the pathogenesis of Huntington's disease via bioinformatics and next generation sequencing data analysis DOI Creative Commons
Basavaraj Vastrad, Chanabasayya Vastrad

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 4, 2025

Abstract Background Huntington's disease (HD) could cause progressive motor deficits, psychiatric symptoms, and cognitive impairment. With the increasing use of pharmacotherapies theoretically target neurotransmitters, incidence HD is still not decreasing. However, molecular pathogenesis have been illuminate. It momentous to further examine HD. Methods The next generation sequencing dataset GSE105041 was downloaded from Gene Expression Omnibus (GEO) database. Using DESeq2 in R bioconductor package screen differentially expressed genes (DEGs) between samples normal control samples. ontology (GO) term REACTOME pathway enrichment were performed on DEGs. Meanwhile, using Integrated Interactions Database (IID) database Cytoscape software construct protein–protein interaction (PPI) network module analysis, identify hub with highest value node degree, betweenness, stress closeness scores. miRNA-hub gene regulatory TF-hub constructed analyzed. Receiver operating characteristic curves analysis for diagnostic genes. Results We identified 958 DEGs, consisting 479 up regulated DEGs down GO terms analyses by g:Profiler online results revealed that mainly enriched multicellular organismal process, developmental signaling GPCR MHC class II antigen presentation. Network Analyzer plugin PPI network, LRRK2, MTUS2, HOXA1, IL7R, ERBB3, EGFR, TEX101, WDR76, NEDD4L COMT selected as Hsa-mir-1292-5p, hsa-mir-4521, ESRRB SREBF1 are potential biomarkers predicted be associated Conclusion This study investigated key pathways interactions its complications, which might help reveal correlation complications. current investigation captured prediction, follow-up biological experiments enforced validation.

Language: Английский

Citations

0
Obesity-associated reduction of miR-150-5p in extracellular vesicles promotes ventilator-induced lung injury by modulating the lysosomal degradation of VE-cadherin DOI Creative Commons
Yi Zhang, Changping Gu, Liang Zhao

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 6, 2025

Abstract Obese patient has a high risk of ventilator-induced lung injury (VILI) but its underlying mechanisms remain elusive. This study was designed to explore the role circulating plasma extracellular vesicles (EVs) on progression VILI in context obesity. After tidal volume mechanical ventilation, mice treated with EVs from obese patients developed more severe damage than normal controls. miRNA sequencing revealed significant downregulation miR-150-5p compared others. found target XBP1s which subsequently regulated RAB7 as verified through dual-luciferase assays. pathway promoted lysosomal degradation vascular endothelial (VE)-cadherin, leading an increased permeability. showed enhanced XBP1s/RAB7 expression, reduced VE-cadherin levels, and aggravated barrier all intensified VILI. Administration agomir mitigated Thus, this highlights low levels modulated severity via axis VE-cadherin.

Language: Английский

Citations

0
Withaferin a modulation of microglia autophagy mitigates neuroinflammation and enhances cognitive function in POCD DOI Creative Commons
Haijun Hu,

Bingbing Cao,

Dan Huang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 30, 2024

Language: Английский

Citations

2
Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases DOI Open Access

Nitzan Sharon,

Ludmila Yarmolinsky,

Boris Khalfin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6402 - 6402

Published: June 10, 2024

Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective anti-inflammatory features, which fundamentally important treatment of neurodegenerative diseases. The aging global population is causing an increase in these diseases that require development effective drugs to be even more urgent. Taking into account unavailability diseases, it seems appropriate consider role cannabinoids To our knowledge, few reviews devoted cannabinoids' impact on modulating central peripheral immunity objective this review provide best possible information about cannabinoid receptors immuno-modulation immune modulation by cannabinoid-based therapies neurological disorders, future prospects making versatile tools pursuit drugs.

Language: Английский

Citations

1
A Comprehensive Exploration of the Multifaceted Neuroprotective Role of Cannabinoids in Alzheimer’s Disease across a Decade of Research DOI Open Access

Petros Tyrakis,

Christina Agridi,

Malamati Kourti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8630 - 8630

Published: Aug. 7, 2024

Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests through dysregulation of brain function and subsequent loss bodily control, attributed to β-amyloid plaque deposition TAU protein hyperphosphorylation aggregation, leading neuronal death. Concurrently, similar cannabinoids the ones derived from Cannabis sativa are present in endocannabinoid system, acting receptors CB1R CB2R other related such as Trpv-1 GPR-55, being extensively investigated for AD therapy. Given limited efficacy adverse effects current available treatments, alternative approaches crucial. Therefore, this review aims identify effective natural synthetic elucidate their beneficial actions treatment. PubMed Scopus databases were queried (2014–2024) using keywords “Alzheimer’s disease” “cannabinoids”. The majority (Δ9-THC, CBD, AEA, etc.) (JWH-133, WIN55,212-2, CP55-940, included showed promise improving memory, cognition, behavioral symptoms, potentially via pathways involving antioxidant selective agonists (such BDNF/TrkB/Akt pathway) immunomodulatory (TLR4/NF-κB p65 pathway). Combining anticholinesterase properties with cannabinoid moiety may enhance therapeutic responses, addressing cholinergic deficits brains. Thus, positive outcomes vast studies discussed support further advancing clinical trials

Language: Английский

Citations

1