Cited by The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex.

The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex. DOI

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Despite the emerging consensus that microglia are critical to physiological and pathological brain function, it is unclear how microglial roles their underlying mechanisms differ between regions. Microglia throughout express common markers, such as purinergic receptor P2Y12, delineate them from peripheral macrophages. P2Y12 a sensor of injury but also contributes sensing neuronal activity remodeling synapses, with loss resulting in behavioral deficits. has largely been studied cortical microglia, despite fact growing body evidence suggests exhibit high degree regional specialization. Cerebellar particular, transcriptional, epigenetic, functional profiles set apart better hippocampal counterparts. Here, we demonstrate deficiency does not alter morphology, distribution, or dynamics cerebellum. In fact, little disturb distinct transcriptomic cerebellar microglia. However, unlike cortex, required for full response focal injury, suggesting use different cues respond injury. Finally, show impairs learning delay eyeblink conditioning task, test plasticity circuit function. Our findings suggest only region-specific signaling response, indicate conserved role modulation across

Language: Английский

Microglial regulation of white matter development and its disruption in autism spectrum disorder DOI

Katherine Canada, Tanya M. Evans, Kevin A. Pelphrey

et al.

Cerebral Cortex, Journal Year: 2025, Volume and Issue: 35(4)

Published: April 1, 2025

Abstract White matter, comprising approximately 50% of the human brain, is crucial for efficient neuronal signaling and a wide range brain functions, including social cognition, sensation, memory, motor control, information integration across cortical regions in service perception cognition. composed myelinated axons, results from complex interactions between different cell types, with oligodendrocytes (OLs) microglia playing integral roles. Microglia, brain's resident immune cells, regulate oligodendrogenesis through phagocytosis molecular signaling, example cytokines, which promote inhibit maturation stages OL lineage cells. Maternal activation (MIA) recognized risk factor neurodevelopmental disorders, especially autism spectrum disorder (ASD). The physiological presentation ASD includes white matter abnormalities dysregulation. Emerging evidence indicates that MIA may reduce microglial reactivity alter cytokine release offspring, potentially disrupting delicate balance required proper development. Understanding intricate interplay oligodendrocytes, microglia, inflammation, development context provides valuable insights into etiology core symptoms possible therapeutic targets.

Language: Английский

Citations

The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex DOI