Journal of Gazi University Health Sciences Institute,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 29, 2024
Since
American
football
is
inherently
a
collision
sport,
exposure
to
repeated
head
impacts
leads
increased
concerns
among
players,
especially
regarding
brain
health.
The
risk
of
neurodegenerative
diseases
may
rise
at
the
later
phase
life
in
case
long-term
continuation
damage
induced
by
repetitive
thereby
leading
chronicity
oxidative
stress
and
neuroinflammation
along
with
blood-brain
barrier
disruption.
Therefore,
early
preventive
strategies
are
necessary
improve
Nutrition
considered
one
these
strategies.
Mediterranean-DASH
Intervention
for
Neurodegenerative
Delay
(MIND)
diet
model
was
designed
MIND
includes
foods
rich
bioactive
compounds,
fiber,
polyunsaturated
fatty
acids
(PUFAs)
monounsaturated
(MUFAs)
anti-inflammatory
antioxidant
characteristics.
this
protect
against
negative
effects
damage.
potential
components,
including
PUFAs,
MUFAs
on
health
players
discussed
review.
Journal of Personalized Medicine,
Journal Year:
2025,
Volume and Issue:
15(1), P. 33 - 33
Published: Jan. 17, 2025
A
significant
proportion
of
patients
who
sustain
a
concussion/mild
traumatic
brain
injury
endorse
persisting,
lingering
symptoms.
The
symptoms
associated
with
concussion
are
nonspecific,
and
many
other
medical
conditions
present
similar
Medical
that
overlap
symptomatically
include
anxiety,
depression,
insomnia,
chronic
pain,
fatigue,
fibromyalgia,
cervical
strain
injuries.
One
the
factors
may
account
for
these
similarities
is
all
disturbances
in
optimal
functioning
autonomic
nervous
system
its
intricate
interactions
endocrine
immune
system—the
three
primary
regulatory
systems
body.
When
clinicians
working
presenting
persisting
after
concussion,
evidence-based
treatment
options
drawn
from
literature
limited.
We
framework
assessment
following
based
on
available
evidence
(treatment
trials),
neuroanatomical
principles
(research
into
physiology
concussion),
clinical
judgment.
review
research
supporting
premise
behavioral
interventions
designed
to
stabilize
optimize
body
have
potential
reduce
improve
patients.
Foundational
rehabilitation
strategies
areas
sleep
stabilization,
fatigue
management,
physical
exercise,
nutrition,
relaxation
protocols,
activation
outlined
along
practical
implementing
intervention
modules
Clinics and Practice,
Journal Year:
2025,
Volume and Issue:
15(3), P. 47 - 47
Published: Feb. 25, 2025
Background:
Traumatic
brain
injury
(TBI)
is
often
associated
with
other
injuries
and
comorbidities.
However,
even
isolated
TBI
directly
leads
to
dysfunction
in
multiple
body
systems
outside
the
central
nervous
system.
These
extracranial
effects
of
target
including
autonomic
nervous,
cardiovascular,
renal,
pulmonary,
immune,
gastrointestinal,
hemostasis
systems,
as
well
causing
significant
alteration
systemic
metabolism.
Aim:
This
review
intended
outline
on
place
these
context
treatment
considerations
for
patients.
Significance:
Systemic
have
implications
acute
critical
care
management
patients
TBI,
pharmacologic
treatment.
They
also
affect
decisions
chronic
care,
TBI-unrelated
routine
medical
TBI.
In
addition,
should
be
considered
research
settings.
Conclusions:
It
important
clinicians
researchers
aware
effects,
consider
their
pathology,
decisions,
interpretation
findings.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Traumatic
brain
injury
(TBI)
is
a
severe
condition
with
high
mortality
rate,
affecting
multiple
organs,
including
the
gastrointestinal
(GI)
tract.
Ghrelin
brain-gut
peptide
that
regulates
microbiota-brain-gut
axis,
facilitating
communication
between
GI
tract
and
central
nervous
system.
This
study
aimed
to
investigate
role
of
ferulic
acid
(FA)
in
regulating
improve
TBI
disorders
(GID)
induced
by
controlled
cortical
impact
(CCI).
used
CCI
as
vivo
model
scratch-induced
primary
astrocytes
vitro
model.
The
mechanism
FA
modulation
ameliorating
GID
were
explored
using
multi-omics
network
pharmacology
analyses.
In
vivo,
results
revealed
main
active
component
Guanxin
II
compound
mimics
its
function.
Significant
improvement
hypomotility
was
observed
group
compared
group.
Concurrently,
ameliorated
intestinal
barrier
impairment
triggered
CCI-induced
reduction
expression
reduces
inflammatory
response.
Furthermore,
16S
rRNA
indicated
worsened
gut
microflora
imbalance
via
while
dysbiosis
aggravated
injury.
improved
Bacteroidetes
Odoribacter
mainly
targeting
Ghrelin-mediated
RNA-seq
analyses
affects
inflammation-mediated
pyroptosis
pathways
axis.
Additionally,
experimental
evidence
demonstrated
reversed
rats
scratch
injury-induced
promoting
binding
GHSR,
which
suppressed
TLR4/NF-κB/NLRP3
pathway.
Conclusively,
could
alleviate
regulate
axis
inflammation
Ghrelin/TLR4/NLRP3
Indian Journal of Neurosurgery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
Abstract
Traumatic
brain
injury
(TBI)
has
profound
effects
that
extend
beyond
the
brain,
affecting
other
body
systems
via
secondary
pathways
and
leading
to
various
complications,
including
gastrointestinal
(GI)
dysfunction
during
after
hospitalization.
While
advances
in
TBI
management
have
improved
overall
outcomes,
absence
of
effective
treatments
for
these
systemic
highlights
urgent
need
innovative
therapeutic
strategies.
A
critical
aspect
this
context
is
brain–gut
axis
(BGA),
a
bidirectional
communication
network
connecting
GI
system
through
complex
neuronal,
hormonal,
immune
pathways.
results
increased
intestinal
permeability
hypercatabolic
state
bacterial
translocation,
dysregulation,
septic
multiorgan
failure.
These
complications
significantly
heighten
risk
morbidity
mortality
patients.
Emerging
evidence
suggests
gut
dysbiosis
plays
pivotal
role
post-TBI
complications.
The
microbiome,
diverse
community
commensal
microorganisms,
integral
physiology,
performing
key
functions
such
as
metabolic
regulation,
maintaining
barrier,
modulating
responses.
Disruptions
microbiota
can
exacerbate
dysfunction,
potentially
severe
outcomes.
This
review
examines
mechanisms
underlying
BGA
following
TBI,
focusing
on
contributing
dysregulation.
Additionally,
it
discusses
strategies
aimed
at
mitigating
dysbiosis.
Potential
interventions
include
approaches
restore
microbial
balance,
enhance
barrier
integrity,
support
modulation.
By
targeting
areas,
therapies
may
reduce
improve
patient
Frontiers in Psychiatry,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 9, 2024
Psychiatric
illness
is
thought
to
be
a
brain
somatic
crosstalk
disorder.
However,
the
existing
phenomenology-based
Diagnostic
and
Statistical
Manual
of
Mental
Disorders,
Fifth
Edition
(DSM-5)
diagnostic
framework
overlooks
various
dimensions
other
than
symptoms.
In
this
study,
we
investigated
associations
between
peripheral
blood
test
indexes
with
symptom
levels
major
depressive
disorder
(MDD),
bipolar
(BD),
schizophrenia
(SCZ)
explore
availability
indexes.