Total Antioxidant Status in Critically Ill Patients with Traumatic Brain Injury and Secondary Organ Failure—A Systematic Review DOI Creative Commons

Ewa Rynkiewicz-Szczepańska,

Urszula Kościuczuk, Mateusz Maciejczyk

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(22), P. 2561 - 2561

Published: Nov. 15, 2024

The available literature indicates that oxidant-antioxidant imbalance plays a significant role in the pathophysiology of traumatic brain injury and subsequent secondary organ dysfunctions. However, there is lack studies summarizing knowledge this area, no clear guidelines exist regarding use biomarkers oxidative stress as diagnostics tools.

Language: Английский

Development of BACE2-IN-1/tranylcypromine-based compounds to induce steroidogenesis-dependent neuroprotection DOI Open Access

Suddhasatwa Banerjee,

Ying-Ting Hsu, Deanna D. Nguyen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117851 - 117851

Published: Jan. 20, 2025

Language: Английский

Citations

0
Extracranial Effects of Traumatic Brain Injury: A Narrative Review DOI Creative Commons
Nathan K. Evanson,

Pratyusha Veldhi,

Caitlyn Scherpenberg

et al.

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(3), P. 47 - 47

Published: Feb. 25, 2025

Background: Traumatic brain injury (TBI) is often associated with other injuries and comorbidities. However, even isolated TBI directly leads to dysfunction in multiple body systems outside the central nervous system. These extracranial effects of target including autonomic nervous, cardiovascular, renal, pulmonary, immune, gastrointestinal, hemostasis systems, as well causing significant alteration systemic metabolism. Aim: This review intended outline on place these context treatment considerations for patients. Significance: Systemic have implications acute critical care management patients TBI, pharmacologic treatment. They also affect decisions chronic care, TBI-unrelated routine medical TBI. In addition, should be considered research settings. Conclusions: It important clinicians researchers aware effects, consider their pathology, decisions, interpretation findings.

Language: Английский

Citations

0
Selective serotonin reuptake inhibitors in the treatment of major depressive disorder after brain trauma: Systematic review and meta-analysis DOI
R L Gao,

Xiaona Zhang,

Peng Zhu

et al.

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(3)

Published: Feb. 26, 2025

Traumatic brain injury (TBI) poses a considerable risk to human health. After TBI, individuals are susceptible range of psychiatric disorders, with depression being primary complication. Selective serotonin reuptake inhibitors (SSRIs) frequently used in the treatment depression; however, their efficacy addressing major depressive disorder (MDD) adults following TBI remains uncertain. To investigate SSRIs MDD after TBI. A comprehensive search across multiple databases was conducted guidelines outlined Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, encompassing studies published until May 2024. This review focused on that examined Studies were assessed based sample size, duration, methodologies, severity injury, assessment techniques, drug response. random-effects model derive summary effect size. Eight compared reduction scores patients SSRI treatment. The eight did not exhibit heterogeneity (I 2 = 38%). score group decreased more than control [odds ratio (OR) 1.68, 95%CI: 1.09-2.58, P 0.02]. adverse reactions included diarrhea, dizziness, dry mouth, nausea, or vomiting. There no difference incidence between two groups (OR 1.16, 0.78-1.73, 0.46]. These show significant 44%). may be effective treating Adequately powered, randomized, controlled trials required confirm these findings.

Language: Английский

Citations

0
Endocrine dysfunction post-traumatic brain injury: challenges and therapeutic approaches DOI
Zahra Soltani,

Masoud Nazari,

Meisam Babaei

et al.

Acta Neurologica Belgica, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

0
Total Antioxidant Status in Critically Ill Patients with Traumatic Brain Injury and Secondary Organ Failure—A Systematic Review DOI Creative Commons

Ewa Rynkiewicz-Szczepańska,

Urszula Kościuczuk, Mateusz Maciejczyk

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(22), P. 2561 - 2561

Published: Nov. 15, 2024

The available literature indicates that oxidant-antioxidant imbalance plays a significant role in the pathophysiology of traumatic brain injury and subsequent secondary organ dysfunctions. However, there is lack studies summarizing knowledge this area, no clear guidelines exist regarding use biomarkers oxidative stress as diagnostics tools.

Language: Английский

Citations

1