Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

et al.

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

Novel neutrophil targeting platforms in treating Glioblastoma: Latest evidence and therapeutic approaches DOI
Rui Zhong,

Hongmei He,

X Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114173 - 114173

Published: Feb. 11, 2025

Language: Английский

Citations

0
Harnessing myeloid cells in cancer DOI Creative Commons
Suyeon Park, Ekaterina Pylaeva, Vikas Bhuria

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 6, 2025

Cancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid with immunosuppressive properties a critical role anti-cancer immune regulation. Cells of different origin, such as associated macrophages (TAMs), neutrophils (TANs), derived suppressor (also called MDSCs) eosinophils are often expanded cancer patients significantly influence survival, but also the outcome therapies. For this reason, variety preclinical clinical studies modulate activity these have been conducted, however without successful date. In review, pro-tumor cells, cell-specific therapeutic targets, vivo on cell re-polarization impact immunotherapies/genetic engineering addressed. This paper summarizes ongoing trials concept chimeric antigen receptor macrophage (CAR-M) therapies, suggests future research perspectives, offering new opportunities development novel treatment strategies.

Language: Английский

Citations

0
Global trends in tumor-associated neutrophil research: a bibliometric and visual analysis DOI Creative Commons
Shaodong Li, Peng Dong, Xueliang Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Tumor-associated neutrophils (TANs) play crucial roles in tumor progression, immune response modulation, and the therapeutic outcomes. Despite significant advancements TAN research, a comprehensive bibliometric analysis that objectively presents current status trends this field is lacking. This study aims to fill gap by visually analyzing global TANs research using knowledge mapping techniques. We retrieved articles reviews related from Web of Science core collection database, spanning period 2012 to2024. The data was analyzed tools such as Excel 365, CiteSpace, VOSviewer, Bibliometrix (R-Tool R-Studio) identify key trends, influential countries institutions, collaborative networks. citation patterns. A total 6l5 publications were included analysis, showing upward trend over last two decades. United States China emerged leading contributors with highest number citations. journal most Frontiers Immunology, Prominent authors Fridlender ZG identified contributor, his works frequently cited. highlighted major themes. including role microenvironment their dual functions promotion suppression, exploration TANs-targeted therapies, Emerging hotspots include studies on plasticity interactions other cells. first employ methods visualize frontiers research. findings provide valuable insights into evolution field, highlighting critical areas for future investigation potential opportunities. serves resource researchers practitioners aiming advance its application cancer therapy.

Language: Английский

Citations

0
The Role of Gut Microbiome on Glioblastoma Oncogenesis and Malignant Evolution DOI Open Access
Zahurin Mohamed, Qiong Wu, Maria A. Jacome

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2935 - 2935

Published: March 24, 2025

Glioblastoma (GBM) remains the most aggressive primary brain tumor, with poor survival outcomes and treatment limited to maximal safe surgical resection, chemotherapy temozolomide, radiotherapy. While immunotherapy targeted treatments show promise, therapeutic resistance disease progression remain major challenges. This is partly due GBM's classification as a "cold tumor" low mutational burden lack of distinct molecular targets for drug delivery that selectively spare healthy tissue. Emerging evidence highlights gut microbiota key player in cancer biology, influencing both glioma development response. review explores intersectionality between microbiome GBM, beginning an overview composition its broader implications pathophysiology. We then examine how specific microbial populations contribute oncogenesis, modulating immune responses, inflammation, metabolic pathways drive tumor initiation progression. Additionally, we discuss microbiome's role resistance, including impact on chemotherapy, radiotherapy, efficacy. Given influence outcomes, evaluate emerging strategies modulate flora, such probiotics, dietary interventions, microbiota-based therapeutics, enhance therapy response GBM patients. Finally, address challenges future directions, emphasizing need standardized methodologies, mechanistic studies, clinical trials validate microbiota-targeted interventions neuro-oncology. By integrating research into paradigms, may unlock novel avenues improve patient outcomes.

Language: Английский

Citations

0
Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

et al.

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

Citations

0