Hydrocephalus Pathophysiology and Epidemiology

Neurosurgery Clinics of North America, Journal Year: 2025, Volume and Issue: 36(2), P. 113 - 126

Published: Feb. 5, 2025

Language: Английский

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Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Feb. 19, 2025

The cerebrospinal fluid (CSF) not only protects the brain but also maintains homeostasis by removing metabolic waste produced activity. This study hypothesizes that chronic CSF circulatory dysfunction, such as hydrocephalus or normal pressure (NPH), may be a critical condition in neurodegenerative diseases associated with accumulation. To investigate circulation and cerebral lymphatic drainage rat model of induced kaolin injection, we performed time-dependent evaluations intraparenchymal injection tracers well intraventricular Evans blue. systemically evaluated dysfunction from various perspectives, including glymphatic system, transependymal flow, subarachnoid meningeal drainage, peripheral to deep cervical lymph nodes. results indicated delayed circulation, kaolin-induced model. Based on these findings, our research observed conditions NPH, act an initiating exacerbating factor diseases. can lead accumulation waste, seen Alzheimer's disease. Our help identify risk factors provide insight into underlying pathophysiology diseases, which development novel therapeutic strategies.

Language: Английский

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The Role of Ciliated Cells of the Spinal Canal

Cell and Tissue Biology, Journal Year: 2025, Volume and Issue: 19(3), P. 191 - 205

Published: April 3, 2025

Language: Английский

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Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

The critical role of the immune system in brain function and dysfunction is well recognized, yet development therapies for psychiatric diseases has been slow due to concerns about iatrogenic deficiencies. These are emphasized by lack objective diagnostic tools psychiatry. A promise resolve this conundrum lies exploitation extracellular vesicles (EVs) that physiologically produced or can be synthetized. EVs regulate recipient cell functions offer potential EVs-based therapies. Intranasal administration enables targeting specific regions functions, thereby facilitating design precise treatments diseases. such requires navigating four dynamically interacting networks: neuronal, glial, immune, EVs. networks profoundly influenced fluid distribution. They crucial homeostasis, cellular intercellular communication. Fluid abnormalities, like edema altered cerebrospinal (CSF) dynamics, disrupt these networks, negatively impacting health. deeper understanding above-mentioned vital creating biomarker panels identify distinct patient subsets with similar neuro-behavioral symptoms. Testing functional pathways biomarkers could lead new therapeutic tools. Regulatory approval will depend on robust preclinical data reflecting progress interdisciplinary areas, which pave way innovative treatments. Highly collaborative teams needed achieve ambitious goals.

Language: Английский

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Internalization of extracellular Tau oligomers in Alzheimer’s disease

Advances in clinical chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Hippocampal Syndrome Secondary to Tuberculosis: From Neuroinflammation to Neurodegeneration

Tuberculosis, Journal Year: 2025, Volume and Issue: unknown, P. 102653 - 102653

Published: May 1, 2025

Language: Английский

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