Alzheimer’s Disease and Porphyromonas gingivalis: Exploring the Links

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 96 - 96

Published: Jan. 14, 2025

Recent research highlights compelling links between oral health, particularly periodontitis, and systemic diseases, including Alzheimer's disease (AD). Although the biological mechanisms underlying these associations remain unclear, role of periodontal pathogens, Porphyromonas gingivalis, has garnered significant attention. P. a major driver is recognized for its potential effects putative in AD pathogenesis. This review examines evidence connecting gingivalis to hallmark features, such as amyloid β accumulation, tau hyperphosphorylation, neuroinflammation, other neuropathological features consistent with AD. Virulence factors, gingipains lipopolysaccharides, were shown be implicated blood-brain barrier disruption, neuronal damage. gingivalis-derived outer membrane vesicles may serve disseminate virulence factors brain tissues. Indirect mechanisms, inflammation triggered by chronic infections, are also supposed exacerbate neurodegenerative processes. While exact pathways uncertain, studies detecting components AD-affected brains support their possible underscores need further investigation into gingivalis-mediated interplay host responses. Understanding interactions could provide critical insights novel strategies reducing risk through management.

Language: Английский

Gut Microbiota Modulation of Dementia Related Complications

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based medicine. One most extensively studied biological pathways is gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies dysbiosis suggest complex behavioral changes, such as alterations sociability and anxiety, can be modulated through microbiota. Specifically, mental disorders include major depression, bipolar disorder, schizophrenia. Gastrointestinal diseases reversed by modulating Dementia its related mechanisms are also amenable modulation This review focuses on role microbiota dementia discussing effects depressive symptoms, cognitive function, mood, chronic stress, prospects microbiota-gut-brain axis for dementia. Although animal models revealed promising approaches treating microbiota, it may premature incorporate these interventions into standard clinical practice. The heterogeneity findings trials randomized control yet convincingly demonstrate efficacy reversing complications.

Language: Английский