The Role of Th17/Treg Axis in Retinal Pathology Associated with Diabetes and Treatment Options DOI Creative Commons
Michel‐Edwar Mickael, Norwin Kubick,

Kreshnik Miftari

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 275 - 275

Published: March 7, 2025

Diabetic retinopathy (DR) is a major complication of diabetes, leading to vision impairment and blindness. The pathogenesis DR involves multiple factors, including hyperglycemia-induced vascular damage, hypertension, obesity, anemia, immune dysregulation, disruption the blood–retinal barrier (BRB). Th17 Treg cells, two types CD4+ T play opposing roles in inflammation. cells are pro-inflammatory, producing cytokines such as IL-17A, while help suppress responses promote anti-inflammatory effects. Recent studies highlight importance Th17/Treg balance retinal inflammation disease progression DR. Our literature review reveals an imbalance DR, with increased activity reduced function. This shift creates pro-inflammatory environment retina, worsening leakage, neovascularization, loss. limited infiltration suggests that may uniquely infiltrate retina by overwhelming or outnumbering Tregs increasing expression recruiting chemokines, rather than only taking advantage damaged BRB. Therapeutic strategies, neutralizing IL-17A enhancing function compounds like IL-35 curcumin, reduce damage. Restoring between could provide new approaches for treating controlling preventing further

Language: Английский

The Role of Th17/Treg Axis in Retinal Pathology Associated with Diabetes and Treatment Options DOI Creative Commons
Michel‐Edwar Mickael, Norwin Kubick,

Kreshnik Miftari

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 275 - 275

Published: March 7, 2025

Diabetic retinopathy (DR) is a major complication of diabetes, leading to vision impairment and blindness. The pathogenesis DR involves multiple factors, including hyperglycemia-induced vascular damage, hypertension, obesity, anemia, immune dysregulation, disruption the blood–retinal barrier (BRB). Th17 Treg cells, two types CD4+ T play opposing roles in inflammation. cells are pro-inflammatory, producing cytokines such as IL-17A, while help suppress responses promote anti-inflammatory effects. Recent studies highlight importance Th17/Treg balance retinal inflammation disease progression DR. Our literature review reveals an imbalance DR, with increased activity reduced function. This shift creates pro-inflammatory environment retina, worsening leakage, neovascularization, loss. limited infiltration suggests that may uniquely infiltrate retina by overwhelming or outnumbering Tregs increasing expression recruiting chemokines, rather than only taking advantage damaged BRB. Therapeutic strategies, neutralizing IL-17A enhancing function compounds like IL-35 curcumin, reduce damage. Restoring between could provide new approaches for treating controlling preventing further

Language: Английский

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