Neural Excitatory/Inhibitory Imbalance in Motor Aging: From Genetic Mechanisms to Therapeutic Challenges

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 272 - 272

Published: March 7, 2025

Neural excitatory/inhibitory (E/I) imbalance plays a pivotal role in the aging process. However, despite its significant impact, of E/I motor dysfunction and neurodegenerative diseases has not received sufficient attention. This review explores mechanisms underlying through lens balance, emphasizing genetic molecular factors that contribute to this (such as SCN2A, CACNA1C, GABRB3, GRIN2A, SYT, BDNF…). Key regulatory genes, including REST, vps-34, STXBP1, are examined for their roles modulating synaptic activity neuronal function during aging. With insights drawn from ALS, we discuss how disruptions balance pathophysiology age-related dysfunction. The genes discussed above exhibit certain association with neuron (like ALS), relationship had been previously recognized. Innovative therapies, such gene editing technology optogenetic manipulation, emerging promising tools restoring offering hope ameliorating deficits potential these technologies intervene aging-related diseases, challenges direct application human conditions.

Language: Английский

Interventions in cytokine signaling: novel horizons for psoriasis treatment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, transforming growth factor-β (TGF-β), are essential for controlling cellular activity immunological responses, maintaining homeostasis contributing to the pathogenesis of psoriasis. These molecules modulate microenvironment by either promoting or suppressing inflammation, which significantly impacts therapeutic outcomes. Recent research indicates treatment strategies targeting chemokines have significant potential, offering new approaches regulating system, inhibiting progression reducing adverse effects traditional therapies. This review consolidates current knowledge on cytokine chemokine signaling pathways in psoriasis examines their significance treatment. Specific attention given like IL-17, IL-23, TNF-α, underscoring necessity innovative therapies these address processes. emphasizes principal part -pathological process explores challenges opportunities they present intervention. Furthermore, we examine recent advancements targeted therapies, with particular focus monoclonal antibodies, ongoing clinical trials.

Language: Английский

Targeting STING and protecting mitochondrial function with Nephropathy Ⅱ Decoction to alleviate renal fibrosis

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156785 - 156785

Published: April 1, 2025

Language: Английский