Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 12, 2024
Objective
The
association
between
vitamin
D
deficiency
and
ovarian
reserve-specific
outcomes
of
assisted
reproductive
technology
(ART)
remains
uncertain.
This
study
aimed
to
investigate
the
role
reserve
in
basal
serum
levels
ART
patients
undergoing
controlled
hyperstimulation
(COH).
Methods
A
total
1,333
infertile
women
COH
cycles
were
retrospectively
analyzed.
Patients
divided
into
a
group
(serum
<
20
ng/mL)
normal
group.
Univariate
multivariate
logistic
regression
analyses
performed
estimate
relationship
pregnancy
including
biochemical
rate,
clinical
miscarriage
live
birth
rate
overall
cohort
subgroups
with
diminished
(DOR)
or
polycystic
ovary
syndrome
(PCOS).
Results
In
entire
participants’
cohort,
no
correlation
results
was
observed
(
p
>
0.05).
However,
DOR
subgroup,
associated
lower
(adjusted
OR
0.27;
95%
CI
0.08–0.90;
0.01)
0.36;
0.14–0.90;
0.01).
No
significant
differences
among
PCOS
Conclusion
Vitamin
does
not
affect
patient
population,
but
it
may
negatively
impact
potentially
leading
poorer
outcomes.
Further
studies
are
needed
clarify
mechanisms
involved
potential
use
screening
supplementation
specific
populations.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 5, 2025
Subfertility
affects
about
10-15%
of
Malaysians,
characterized
by
difficulty
conceiving
after
12
months
unprotected
intercourse.
Emerging
research
suggests
that
vitamin
D
deficiency,
influenced
dietary
intake
and
sleep
patterns,
may
contribute
to
fertility.
This
study
examines
the
relationship
between
chrononutrition
quality
deficiency
in
subfertile
patients.
A
cross-sectional
was
conducted
at
two
hospitals
Selangor,
Malaysia,
involving
140
individuals
who
fit
inclusion
exclusion
criteria.
Data
were
collected
through
self-administered
questionnaires,
including
food
frequency
questionnaires
(FFQ),
Chrononutrition
Profile
Questionnaire
(CPQ),
Pittsburgh
Sleep
Quality
Index
(PSQI).
Serum
levels
measured
25-hydroxyvitamin
blood
test.
Statistical
analyses
performed
using
SPSS
version
29.
Results
revealed
a
significant
difference
mean
serum
male
female
participants
(p
<
0.001),
with
76.7%
females
being
deficient.
Most
parameters
not
males
compared
females.
Notably,
negative
correlation
found
both
energy
fat
0.05).
Female
gender
identified
as
determinant
(OR
5.186,
p
while
poor
evening
eating
habits
strongly
associated
(AOR
10.553,
These
findings
highlight
importance
patterns
among
Hence,
there
is
need
for
targeted
nutritional
lifestyle
interventions.
Medical Science of Ukraine (MSU),
Journal Year:
2025,
Volume and Issue:
21(1), P. 71 - 76
Published: March 31, 2025
Aim:
To
assess
the
impact
of
vitamin
D
deficiency
on
fertility
female
rats
and
evaluate
effectiveness
its
correction
through
D3
supplementation.
Materials
Methods.
The
study
was
conducted
41
Wistar
albino
rats.
animals
were
divided
into
three
groups:
Group
I
(vitamin
deficiency,
n=16),
II
(deficiency
+
D3,
n=15),
control
group
(n=10).
housing
conditions
complied
with
biological
research
standards.
induce
fed
a
special
D-hypovitaminosis
diet.
determination
25(OH)D
levels
carried
out
at
Department
Vitamins
Coenzymes
Palladin
Institute
Biochemistry.
Pregnancy
confirmed
by
microscopic
analysis
vaginal
smears.
Statistical
performed
using
MedStat
v.5.2
EZR
v.3.4.1
software.
Shapiro-Wilk
test
used
to
check
normal
distribution,
Student’s
t-test
applied
compare
groups.
Results
considered
statistically
significant
p<0,05.
Results.
pregnancy
rate
lowest
in
(56,3%),
while
II,
after
supplementation,
it
increased
66,7%,
compared
90%
(p<0,05).
highest
conception
confirms
importance
maintaining
adequate
for
reproductive
function.
Although
correcting
improved
indicators,
did
not
reach
observed
group.
Conclusion.
Vitamin
significantly
reduces
which
may
be
associated
hormonal
imbalance
ovulatory
dysfunction.
supplementation
increases
demonstrating
positive
effect
correction.
corrected
values
(90%),
indicating
need
comprehensive
approach
normalizing
levels.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(4), P. e0319812 - e0319812
Published: April 1, 2025
The
vitamin
D
endocrine
system,
primarily
mediated
by
its
main
metabolite
calcitriol
and
the
receptor
(VDR),
plays
a
critical
role
in
numerous
human
physiological
processes,
ranging
from
calcium
metabolism
to
prevention
of
various
tumors,
including
cervical
cancer.
In
this
study,
we
comprehensively
investigated
genomic
regulatory
effects
cancer
model.
We
examined
transcriptional
changes
induced
CaSki
cells,
cell
line
harboring
multiple
copies
HPV16,
primary
causal
agent
Our
microarray
findings,
revealed
that
regulated
over
1000
protein-coding
genes,
exhibiting
predominantly
repressive
effect
on
transcriptome
suppressing
twice
as
many
genes
it
induced.
Calcitriol
decreased
EPHA2
RARA
expression
while
inducing
KLK6
CYP4F3
validated
qPCR
Western
blot.
Functional
analysis
demonstrated
effectively
inhibited
key
processes
involved
progression,
proliferation
migration.
This
was
further
supported
significant
downregulation
MMP7
MMP13
mRNA
levels.
results
also
showed
that,
addition
significantly
regulates
non-coding
RNAs,
altering
approximately
400
111
microRNA
precursors
29
mature
microRNAs,
which
17
were
upregulated
12
downregulated.
Notably,
among
these
calcitriol-regulated
microRNAs
are
some
biology,
such
miR-6129,
miR-382,
miR-655,
miR-211,
miR-590,
miR-130a,
miR-301a,
miR-1252.
Collectively,
findings
suggest
exhibits
antitumor
advanced
model
blocking
for
tumor
underscoring
importance
maintaining
adequate
nutritional
status.
Women,
Journal Year:
2024,
Volume and Issue:
4(4), P. 453 - 468
Published: Nov. 18, 2024
The
world
of
science
is
increasingly
looking
for
answers
to
the
question
how
specific
dietary
components
affect
risk
chronic
diseases
and
assessing
their
potential
alleviate
severity
individual
diseases.
This
research
concerns
both
assessment
benefits
using
those
nutritional
models.
Endometriosis,
due
its
inflammatory
nature,
also
a
topic
interest
among
scientists,
who
seek
support
course
through
proper
nutrition.
In
endometriosis,
great
focused
on
patterns
such
as
an
anti-inflammatory
diet,
gluten-free
low-FODMAP
or
Mediterranean
diet.
An
diet
primarily
focuses
fresh
vegetables,
fruits,
seeds,
nuts,
whole
grain
products,
healthy
sources
protein
fats,
including
mono-
polyunsaturated
fatty
acids,
eliminating
highly
processed
meat
trans
refined
sugars.
It
believed
that
this
type
may
contribute
reducing
endometriosis
symptoms
help
reduce
inflammation.
aim
review
identify
main
trends
in
field
diets
supporting
treatment
last
5
years.
Nutrients,
Journal Year:
2024,
Volume and Issue:
17(1), P. 103 - 103
Published: Dec. 30, 2024
Background/Aim:
Subfertility
is
characterized
by
a
decrease
in
reproductive
efficiency,
which
can
result
delayed
pregnancy,
and
affects
one
six
individuals
during
their
lifetime.
The
present
narrative
review
aims
to
evaluate
the
contribution
of
precision
nutrition
changes
fertility
subfertile
couples.
Methods:
literature
was
carried
out
through
bibliographic
research
PubMed,
Scopus,
SciELO
Google
Scholar
databases.
following
search
criteria
were
applied:
(1)
original
articles
narrative,
systematic
or
meta-analytic
reviews,
(2)
individual
combined
use
keywords:
“genetic
variation”,
“nutrigenetics”,
“precision
nutrition”,
“couple’s
subfertility”,
infertility”.
A
preliminary
reading
all
out,
only
those
that
best
fit
themes
subthemes
selected.
Results:
Scientific
evidence
suggests
adherence
healthy
diet
follows
Mediterranean
pattern
associated
with
increased
women
improved
semen
quality
men,
better
metabolic
health
reduced
levels
inflammation
oxidative
stress,
as
well
maintaining
body
weight.
integration
different
tools,
such
nutrigenetics,
predictive
biochemical
analyses,
intestinal
microbiota
tests
clinical
software,
used
interventions
contribute
providing
information
on
how
genetics
interact
they
influence
fertility.
Conclusions:
adoption
multidisciplinary
approach
allows
design
dietary
lifestyle
recommendations
adapted
specific
characteristics
needs
couples
subfertility,
thus
optimizing
outcomes
achieving
successful
conception.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 8, 2024
Subfertility,
a
condition
marked
by
reduced
capacity
to
conceive
naturally,
affects
significant
proportion
of
couples
globally.
Nutrition
is
fundamental
aspect
reproductive
health,
with
various
nutrients
essential
in
maintaining
optimal
function.
This
comprehensive
review
explores
the
intricate
relationship
between
nutritional
deficiencies
and
subfertility.
It
examines
key
micronutrients
such
as
vitamins
D,
E,
C,
B12,
well
minerals
zinc,
iron,
selenium,
magnesium,
their
impacts
on
fertility.
The
also
considers
macronutrients
importance
balanced
diet
supporting
health.
Drawing
an
extensive
body
clinical
evidence
studies,
this
highlights
how
these
can
lead
hormonal
imbalances,
impaired
gametogenesis,
suboptimal
pregnancy
outcomes.
discusses
efficacy
interventions,
including
dietary
supplements
lifestyle
modifications,
improving
Furthermore,
it
addresses
emerging
research
personalized
nutrition
its
potential
enhance
underscores
necessity
for
healthcare
providers
assess
address
status
patients
provides
practical
recommendations
developing
plans,
counseling
patients,
integrating
interventions
into
fertility
treatments.
By
offering
synthesis
current
evidence,
aims
inform
practice
promote
further
role
enhancing
