THE IMPACT OF VITAMIN D DEFICIENCY ON P65 NF-KB ACTIVITY IN THE PATHOGENESIS OF PLACENTAL DYSFUNCTION DOI Creative Commons
I.V. Poladych

Medical Science of Ukraine (MSU), Journal Year: 2024, Volume and Issue: 20(4), P. 27 - 35

Published: Dec. 30, 2024

Aim: To study the role of vitamin D in activation nuclear factor kB (NF-kB) as a development placental disorders. Materials and methods: The involved 135 women who were observed gave birth at Municipal Non-Profit Enterprise "Perinatal Center Kyiv." research was conducted case-control study, including 105 pregnant main group with dysfunction (Group I – 70 deficiency below 20 ng/ml, Group II 35 between 30 ng/ml) control physiological course pregnancy uncomplicated term deliveries. concentration 25(OH)D blood measured using immunoassay method Monobind reagent kit (USA) Sinnova ER 500 microplate reader (China). determination p65 NF-kB carried out RayBio Human Procalcitonin ELISA (RayBiotech, Inc., USA) Phospho-NF-kB P65 (Ser536) Total Kit. Statistical analysis data performed MedStat v.5.2 EZR v.3.4.1 software. Initially, normality distribution checked Shapiro-Wilk test, followed by application multiple comparisons Kruskal-Wallis rank-based one-way variance. significance determined p < 0.05. Results. revealed significant difference levels total phosphorylated protein groups (p 0.05). In deficiency, there marked increase (median 69.5 pg/ml) its activated form, indicating inflammatory processes placenta. Clinical manifestations dysfunction, such fetal growth restriction, preeclampsia, preterm labor, one-third deficiency. This accompanied changes hormonal function placenta (a decrease progesterone stabilization lactogen) morphological signs abnormalities. activity highest abnormalities, particularly link inflammation Conclusion. Vitamin ng/ml are associated factor, which correlates regardless outcomes. confirms

Language: Английский

Ovarian reserve modulates the impact of vitamin D deficiency on assisted reproductive outcomes in patients undergoing controlled ovarian hyperstimulation DOI Creative Commons
Lina He,

Qing Xu,

Hao Li

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 12, 2024

Objective The association between vitamin D deficiency and ovarian reserve-specific outcomes of assisted reproductive technology (ART) remains uncertain. This study aimed to investigate the role reserve in basal serum levels ART patients undergoing controlled hyperstimulation (COH). Methods A total 1,333 infertile women COH cycles were retrospectively analyzed. Patients divided into a group (serum &lt; 20 ng/mL) normal group. Univariate multivariate logistic regression analyses performed estimate relationship pregnancy including biochemical rate, clinical miscarriage live birth rate overall cohort subgroups with diminished (DOR) or polycystic ovary syndrome (PCOS). Results In entire participants’ cohort, no correlation results was observed ( p &gt; 0.05). However, DOR subgroup, associated lower (adjusted OR 0.27; 95% CI 0.08–0.90; 0.01) 0.36; 0.14–0.90; 0.01). No significant differences among PCOS Conclusion Vitamin does not affect patient population, but it may negatively impact potentially leading poorer outcomes. Further studies are needed clarify mechanisms involved potential use screening supplementation specific populations.

Language: Английский

Citations

0
Study of the association of niacin and vitamin B6 intake with endometriosis: Evidence from NHANES 2003–2006 DOI Open Access

Jiangxin Sheng,

Limei Chen,

Yan Han

et al.

International Journal of Gynecology & Obstetrics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Language: Английский

Citations

0
THE IMPACT OF VITAMIN D DEFICIENCY ON P65 NF-KB ACTIVITY IN THE PATHOGENESIS OF PLACENTAL DYSFUNCTION DOI Creative Commons
I.V. Poladych

Medical Science of Ukraine (MSU), Journal Year: 2024, Volume and Issue: 20(4), P. 27 - 35

Published: Dec. 30, 2024

Aim: To study the role of vitamin D in activation nuclear factor kB (NF-kB) as a development placental disorders. Materials and methods: The involved 135 women who were observed gave birth at Municipal Non-Profit Enterprise "Perinatal Center Kyiv." research was conducted case-control study, including 105 pregnant main group with dysfunction (Group I – 70 deficiency below 20 ng/ml, Group II 35 between 30 ng/ml) control physiological course pregnancy uncomplicated term deliveries. concentration 25(OH)D blood measured using immunoassay method Monobind reagent kit (USA) Sinnova ER 500 microplate reader (China). determination p65 NF-kB carried out RayBio Human Procalcitonin ELISA (RayBiotech, Inc., USA) Phospho-NF-kB P65 (Ser536) Total Kit. Statistical analysis data performed MedStat v.5.2 EZR v.3.4.1 software. Initially, normality distribution checked Shapiro-Wilk test, followed by application multiple comparisons Kruskal-Wallis rank-based one-way variance. significance determined p < 0.05. Results. revealed significant difference levels total phosphorylated protein groups (p 0.05). In deficiency, there marked increase (median 69.5 pg/ml) its activated form, indicating inflammatory processes placenta. Clinical manifestations dysfunction, such fetal growth restriction, preeclampsia, preterm labor, one-third deficiency. This accompanied changes hormonal function placenta (a decrease progesterone stabilization lactogen) morphological signs abnormalities. activity highest abnormalities, particularly link inflammation Conclusion. Vitamin ng/ml are associated factor, which correlates regardless outcomes. confirms

Language: Английский

Citations

0