Perturbations of the endometrial immune microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy DOI Creative Commons
Jialu Shi,

Qianhan Xu,

Shuyi Yu

et al.

Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 18, 2025

Abstract The impact of endometriosis and adenomyosis on reproduction pregnancy is significant, with both conditions linked to increased rates infertility, poor ovarian function in women endometriosis, elevated complications those adenomyosis. However, the underlying mechanisms remain largely unclear. Both share a similar pathophysiological process characterized by growth ectopic endometrium, which may originate from eutopic endometrium. Notably, surgical removal lesions does not appear significantly improve reproductive outcomes, further underscoring importance endometrium these adverse effects. Emerging evidence indicates substantial differences endometrial NK cells, macrophages, T leading inflammatory responses These alterations contribute only disease progression but also defective receptivity, insufficient angiogenesis remodeling, impaired maternal-fetal immune tolerance, placentation, thereby influencing embryo implantation maintenance. This provides an immunological perspective explain higher infertility observed affected women. Therefore, we systematically review cells compared healthy controls, exploring potential impacts changes pregnancy. aims lay groundwork for future studies immunopathogenesis associated adenomyosis-related failure complications, shedding lights development immunotherapeutic strategies mitigate

Language: Английский

Perturbations of the endometrial immune microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy DOI Creative Commons
Jialu Shi,

Qianhan Xu,

Shuyi Yu

et al.

Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 18, 2025

Abstract The impact of endometriosis and adenomyosis on reproduction pregnancy is significant, with both conditions linked to increased rates infertility, poor ovarian function in women endometriosis, elevated complications those adenomyosis. However, the underlying mechanisms remain largely unclear. Both share a similar pathophysiological process characterized by growth ectopic endometrium, which may originate from eutopic endometrium. Notably, surgical removal lesions does not appear significantly improve reproductive outcomes, further underscoring importance endometrium these adverse effects. Emerging evidence indicates substantial differences endometrial NK cells, macrophages, T leading inflammatory responses These alterations contribute only disease progression but also defective receptivity, insufficient angiogenesis remodeling, impaired maternal-fetal immune tolerance, placentation, thereby influencing embryo implantation maintenance. This provides an immunological perspective explain higher infertility observed affected women. Therefore, we systematically review cells compared healthy controls, exploring potential impacts changes pregnancy. aims lay groundwork for future studies immunopathogenesis associated adenomyosis-related failure complications, shedding lights development immunotherapeutic strategies mitigate

Language: Английский

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