Immunotherapy and pan-apoptotic characterization of the tumor microenvironment in gastric cancer (STAD): a single-cell multidimensional analysis DOI Creative Commons
Sheng Zhang, Jianhong Wang, Huan Zhang

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 13, 2024

The aim of this study was to elucidate the critical role autophagy-related gene aggregation in gastric cancer tumor microenvironment cells and investigate their major roles cellular functions. In particular, expression these genes tumor-associated fibroblast subtypes scrutinized an attempt explain cell-subpopulation-specific cell–cell communication regulation study, single-cell RNA sequencing data were first analyzed multiple steps, including preprocessing, cell clustering, classification. Cell subpopulations patterns identified using unsupervised non-negative matrix factorization (NMF) techniques. dynamic aggregates various types deciphered by pseudotime trajectory analysis (PTA). Intercellular performed CellChat R software package, revealing intricate exchange key signaling molecules between subpopulations, SCENIC used identify regulatory networks reveal mechanisms behind heterogeneity. associated with pan-apoptosis NMF decomposition analysis. Cell–cell revealed subpopulations. Dynamic aggregated pseudotemporal STAD observed PTA. subtype, different ligand-receptor interactions immunomodulation observed. By deeply analyzing comparing within intercellular communication, provides new insights into pan-apoptosis-related regulating immune responses functions cancer. These findings pave way for further exploration tumorigenesis regulation, as well laying foundation potential therapeutic strategies.

Language: Английский

The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications DOI Open Access
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 386 - 386

Published: Jan. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Language: Английский

Citations

6
The effects of loss of Y chromosome on male health DOI Creative Commons
Bożena Bruhn‐Olszewska,

Ellen Markljung,

Edyta Rychlicka-Buniowska

et al.

Nature Reviews Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

2
From pixels to prognosis: radiomics and AI in Alzheimer’s disease management DOI Creative Commons
Dequn Peng, Weiyi Huang, Ren Ping Liu

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Alzheimer’s disease (AD), the leading cause of dementia, poses a growing global health challenge due to an aging population. Early and accurate diagnosis is essential for optimizing treatment management, yet traditional diagnostic methods often fall short in addressing complexity AD pathology. Recent advancements radiomics artificial intelligence (AI) offer novel solutions by integrating quantitative imaging features machine learning algorithms enhance prognostic precision. This review explores application AI AD, focusing on key modalities such as PET MRI, well multimodal approaches combining structural functional data. We discuss potential these technologies identify disease-specific biomarkers, predict progression, guide personalized interventions. Additionally, addresses critical challenges, including data standardization, model interpretability, integration into clinical workflows. By highlighting current achievements identifying future directions, this article underscores transformative AI-driven reshaping diagnostics care.

Language: Английский

Citations

2
Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance DOI Creative Commons
Liang Liu, Xian Zhang, Yan Chai

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 28, 2025

Abstract The understanding of neuroimmune function has evolved from concepts immune privilege and protection to a new stage interaction. discovery skull meninges channels (SMCs) opened avenues for central nervous system (CNS) immunity. Here, we characterize bone marrow SMCs by detailing the anatomical structures adjacent skull, differences between peripheral marrow, mainstream animal processing methods, role in monitoring various CNS diseases. Additionally, highlight several unresolved issues based on current research findings, aiming guide future directions.

Language: Английский

Citations

1
3-(3-(diethylamino)propyl)-2-(4-(methylthio)phenyl)thiazolidin-4-one Attenuates Scopolamine-induced Cognitive Impairment in Rats: Insights Into Neuroprotective Effects DOI
Anita Ávila de Souza, Kelen Cristiane Machado Goularte, Raphaela Cassol Piccoli

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Language: Английский

Citations

1
The role of monocytes and macrophages in the progression of Alzheimer’s disease DOI Creative Commons

Wenyi Nie,

Yingbin Yue,

Jingqing Hu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and neuroinflammation. Monocytes macrophages, particularly microglia, play dual role in AD pathogenesis. In the early stages, they delay progression phagocytosing Aβ, but chronic activation leads to Aβ accumulation exacerbated Monocyte chemoattractant protein 1 (MCP-1) key regulator neuroinflammation, deposition, tau pathology, making it potential therapeutic target. Moreover, recent breakthroughs fluid imaging biomarkers targeted immunomodulatory agents underscore growing importance of diagnostic interventions. This review explores complex interplay between monocytes, highlighting their roles metabolism, phosphorylation. Understanding these mechanisms offers new insights into developing effective strategies for AD.

Language: Английский

Citations

1
Peripheral immune profile and neutrophil‐to‐lymphocyte ratio in progressive supranuclear palsy: Case–control study and meta‐analysis DOI Creative Commons
Laura Muñoz‐Delgado,

Antonio Luque‐Ambrosiani,

Belén Benítez Zamora

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 31(12)

Published: Aug. 20, 2024

Abstract Background and purpose Peripheral inflammation is probably involved in the pathogenesis of progressive supranuclear palsy (PSP) it may be a common feature with Parkinson's disease (PD). The peripheral immune profile PSP remains unclear, as well whether inflammatory pathways differ from those PD. neutrophil‐to‐lymphocyte ratio (NLR) has been proven to well‐established biomarker systemic inflammation. This study aimed evaluate compared Methods A cross‐sectional was conducted including patients PD healthy controls (HCs). Leukocyte subpopulations NLR were measured blood. Multivariate linear regression post hoc tests applied. Electronic databases searched November 2023 perform meta‐analyses clarify PSP. Results Our cohort included 121 PSP, 127 266 HCs. higher had neutrophil count Whilst lower lymphocyte found HCs, did not between supported this profile. Conclusions show an increased Different pathogenic mechanisms are PD, since altered mainly driven by neutrophils. Understanding neutrophils' role allow for development targeted therapies.

Language: Английский

Citations

3
Systems Pharmacology Approach and Experiment Evaluation Reveal Pterocarpus Mildbraedii (Fabaceae) Intervention for Counteracting Behavioral Changes and Neuroinflammatory and Oxidative Stress Markers Against Lps-Induced Alzheimer's Disease in Rats DOI
Mengue Ngadena Yolande Sandrine, Pascal Emmanuel Owona,

Armand Fils Ella

et al.

Published: Jan. 1, 2025

Ethnopharmacological relevance: Pterocarpus mildbraedii was believed to have multiple benefits, including antioxidant, antipyretic, antalgic, anti-convulsant, and anxiolytic effects. Previous studies reported that water extract (Pm) contained secondary metabolites able cross the BBB. However, Pm's systemic mechanism targets for neuroinflammation remain largely unexplored.Aim of study: This research used a systems pharmacology approach experiment evaluation reveal potential protective effects Pm against neuroinflammation, oxidative stress, behavioral changes in an LPS-induced Alzheimer's disease (AD) rat model.Materials methods: integrated network analysis experimental verification evaluate pharmacological PM AD systematically. Swiss Target Prediction, GeneCards, STRING databases were employed identify targets. The interaction between active components hub confirmed via molecular docking. GO KEGG pathway analyses also carried out. Further, vitro bioassays explore anti-inflammatory antioxidant activities and, finally, vivo neuroinflammatory stress markers.Results: Network docking revealed primarily regulates signaling pathways such as ESR1, ESR2, BACE1, MAPK1, TLR4, IL6, GSK3B through like liquiritigenin pterocarptriol. identified significant action AD, nitrogen metabolism VEGF pathway. In vitro, demonstrated their properties, along with inhibitory on AchE BchE. Behavioral tests showed LPS exposure impaired exploratory behavior, spatial learning, increased anxiety rats, correlating brain, marked by elevated MDA NO levels, decreased CAT, SOD, GSH levels. raised TNF-α IL-6 levels while reducing dopamine, serotonin, AChE activity. Notably, treatment significantly mitigated improved activity, restored neurotransmitter animals.Conclusion: paper established P. could inhibit its components, targets, pathways. milbraedii may be candidate treatment.

Language: Английский

Citations

0
Developing Non-Invasive Molecular Markers for Early Risk Assessment of Alzheimer's Disease DOI Creative Commons

Tapas Kumar Sur,

Tanmoy Mondal, Zarish Noreen

et al.

Biomarkers in Neuropsychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 100120 - 100120

Published: Jan. 1, 2025

Language: Английский

Citations

0
Transcriptome analysis reveals that the injection of mesenchymal stem cells remodels extracellular matrix and complement components of the brain through PI3K/AKT/FOXO1 signaling pathway in a neuroinflammation mouse model DOI Creative Commons

Zhihao Xu,

Keqin Liu,

Guoqing Zhang

et al.

Genomics, Journal Year: 2025, Volume and Issue: 117(3), P. 111033 - 111033

Published: March 22, 2025

Language: Английский

Citations

0