The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brain Stimulation Techniques DOI Open Access
Igor Val Danilov

OBM Neurobiology, Journal Year: 2024, Volume and Issue: 08(04), P. 1 - 23

Published: Nov. 29, 2024

This narrative review of the literature on noninvasive brain stimulation techniques observes four neurostimulation domains: light therapy, photobiomodulation, a group within transcranial electric current and magnetic field stimulations, low-frequency sound including vibroacoustic rhythmic auditory stimulation. The aims to determine whether or not different approaches rely upon similar physicochemical sequence actions. study identifies relevant hypotheses about processes at cellular level underlying data analysis reveals that mitochondria activity will likely play central role in stimulations implemented by approaches. Additionally, mother-fetus neurocognitive model gives insight into conditions natural fetal nervous system during pregnancy. Drawing these findings, article supposes hypothesis origin gestation. presents requisites nature-based technique, called Acoustic Photonic Intellectual Neurostimulation (APIN), derived from studying components.

Language: Английский

Photobiomodulation in the aging brain: a systematic review from animal models to humans DOI Creative Commons

Lucia Rodríguez-Fernández,

Candela Zorzo,

Jorge L. Arias

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Abstract Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) non-pharmacological therapy shows promising results in the treatment or prevention of age-related impairments. The aim this review to compile preclinical and clinical evidence effect PBM during aging healthy pathological conditions, including behavioral analysis neuropsychological assessment, as well brain-related modifications. 37 studies were identified by searching PubMed, Scopus, PsycInfo databases. Most use wavelengths 800, 810, 1064 nm but intensity days application highly variable. In animal studies, it has been shown improvements spatial memory, episodic-like social while different have found recognition memory. Locomotor activity improved Parkinson disease models. aged humans, outlined working inhibition, lexical/semantic access, general cognition was mainly enhanced on Alzheimer mild impairment. Anxiety assessment scarce mixed results. As for brain activity, outline effects reversing metabolic alterations enhancing mitochondrial function, evidenced restored CCO ATP levels. Additionally, demonstrated neuroprotective, anti-inflammatory, immunomodulatory hemodynamic effects. findings suggest holds promise non-invasive intervention modulation functional reorganization. It necessary develop standardized protocols correct, beneficial, homogeneous PBM.

Language: Английский

Citations

7
The effect of 807‐nm light‐emitting diode photobiomodulation on peripheral nerve injury DOI Open Access
Biao Chang, Qi Quan, Xinyue Liang

et al.

Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Photobiomodulation (PBM) has demonstrated potential in promoting peripheral nerve regeneration. However, there is a limited and inconclusive study on the application of light‐emitting diode (LED) for injury repair. In this study, we designed an 807‐nm LED device with high luminous uniformity to investigate effects LED‐based PBM RSC96 cells were utilized as target optimal light parameters selected based ATP concentration, CCK‐8 assays, PCR, immunofluorescent staining. One‐way analysis variance Student's t ‐test was used statistical tests. irradiation at 10 mW/cm 2 30 min effectively enhanced Schwann cell proliferation, neurotrophic factor secretion, MBP synthesis. To translate cellular animal studies, transmittance through freshly obtained rat skin biceps femoris muscle assessed, approximately 30%. After directly daily irradiating sciatic area rats 21 days 33 min, gait analysis, immunofluorescence staining, wet weight ratio, Masson transmission electron microscopy evaluate recovery. significantly improved index, increased staining intensity, myelin sheath thickness, diameter, axon diameter. These results indicated feasibility treatment method injuries.

Language: Английский

Citations

0
Brain photobiomodulation: a potential treatment in Alzheimer’s and Parkinson’s diseases DOI Creative Commons
Guillaume Blivet,

Benjamin Touchon,

Hugo Cavadore

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100185 - 100185

Published: April 1, 2025

Language: Английский

Citations

0
Effects of Photobiomodulation Application on Glutathione‐Related Antioxidant Defense System in Rabbit Eye Tissues DOI Creative Commons
Mehmet Özcan, Ayşe Buruş, Etkin Boynuyoğun

et al.

Journal of Biophotonics, Journal Year: 2024, Volume and Issue: 17(10)

Published: Aug. 29, 2024

Photobiomodulation (PBM) has emerged as a potentially effective therapeutic approach to modulate cellular functions. This study aimed examine the impact of PBM on reactive oxygen species (ROS), lipid peroxidation, and glutathione-related antioxidant defense systems in rabbit eye tissues. A polychromatic light source with an intensity 2.6 J/cm

Language: Английский

Citations

2
Recent Advances in Near-infrared Photobiomodulation for the Intervention of Acquired Brain Injury DOI Creative Commons

Yujing Huang,

Yujing Zhang,

Chen Yang

et al.

Journal of Innovative Optical Health Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Acquired brain injury (ABI) is an that affects the structure and function. Traditional ABI treatment strategies, including medications rehabilitation therapy, exhibit their ability to improve its impairments in cognition, emotion, physical activity. Recently, near-infrared (NIR) photobiomodulation (PBM) has emerged as a promising intervention method for ABI, demonstrating low-level light therapy can modulate cellular metabolic processes, reduce inflammation reactive oxygen species of microenvironments, promote neural repair regeneration. Preclinical studies using models have been carried out, revealing potential PBM promoting recovery although clinical application still early stages. In this review, we first inspected possible biological mechanisms NIR-PBM, then reported pathophysiology physiology underlying NIR-PBM intervention. Therefore, therapeutic was demonstrated it also expected further work facilitate applications.

Language: Английский

Citations

0
Development and optical characterisation of agarose-based phantoms mimicking biological tissues for studies of light penetration in the brain DOI
Filipa Fernandes, M. R. Pereira, Delfim Soares

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Searching for materials that accurately mimic the optical properties of biological tissues is essential, particularly transcranial photobiomodulation research, where it necessary to comprehend how light propagates through head tissues.

Language: Английский

Citations

0
Noninvasive Ultra Low Intensity Light Photodynamic Treatment of Glioblastoma with Drug Augmentation: LoGlo PDT Regimen DOI Creative Commons
Richard E. Kast,

Anton Kast,

Jürgen Arnhold

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1164 - 1164

Published: Nov. 21, 2024

This paper presents the basis for LoGlo PDT, a new treatment glioblastoma. Glioblastoma is currently treated with maximal safe resection, temozolomide, and ionizing irradiation. Mortality in 2024 remains over 80% within several years from diagnosis. Oral 5-aminolevulinic acid (5-ALA) an FDA/EMA approved drug that selectively taken up by malignant cells, including In photodynamic of glioblastoma, intense intraoperative light causes glioblastoma tissue has 5-ALA to generate cytotoxic reactive oxygen species. The requirement flux restricted single one-hour session. We analyze here published data showing external light, illuminating entire intact scalp, can attain low μW/cm2 cm into brain would be sufficient mediate if are delivered continuously 24 h. At core PDT regimen dataset that, given fluence, as duration delivery goes down, intensity (flux) must go achieve same cell cytotoxicity weaker (lower flux) longer time. Thus, repetitive, noninvasive using source may possible. cellular physiology show three non-oncology drugs, ciprofloxacin, deferiprone, telmisartan, repurposed increase energy capture after 5-ALA, thereby increasing treatment’s cytotoxicity. approach uses both augmentation prolonged ultra-low transcranial

Language: Английский

Citations

0
The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brain Stimulation Techniques DOI Open Access
Igor Val Danilov

OBM Neurobiology, Journal Year: 2024, Volume and Issue: 08(04), P. 1 - 23

Published: Nov. 29, 2024

This narrative review of the literature on noninvasive brain stimulation techniques observes four neurostimulation domains: light therapy, photobiomodulation, a group within transcranial electric current and magnetic field stimulations, low-frequency sound including vibroacoustic rhythmic auditory stimulation. The aims to determine whether or not different approaches rely upon similar physicochemical sequence actions. study identifies relevant hypotheses about processes at cellular level underlying data analysis reveals that mitochondria activity will likely play central role in stimulations implemented by approaches. Additionally, mother-fetus neurocognitive model gives insight into conditions natural fetal nervous system during pregnancy. Drawing these findings, article supposes hypothesis origin gestation. presents requisites nature-based technique, called Acoustic Photonic Intellectual Neurostimulation (APIN), derived from studying components.

Language: Английский

Citations

0