Application of Traditional Vaccine Development Strategies to SARS-CoV-2

mSystems, Journal Year: 2023, Volume and Issue: 8(2)

Published: March 2, 2023

Over the past 150 years, vaccines have revolutionized relationship between people and disease. During COVID-19 pandemic, technologies such as mRNA received attention due to their novelty successes. However, more traditional vaccine development platforms also yielded important tools in worldwide fight against SARS-CoV-2 virus. A variety of approaches been used develop that are now authorized for use countries around world. In this review, we highlight strategies focus on viral capsid outwards, rather than nucleic acids inside. These fall into two broad categories: whole-virus subunit vaccines. Whole-virus virus itself, either an inactivated or attenuated state. Subunit contain instead isolated, immunogenic component Here, candidates apply these different ways. a companion manuscript, review recent novel nucleic-acid based technologies. We further consider role programs played prophylaxis at global scale. Well-established proved especially making accessible low- middle-income countries. Vaccine established undertaken much wider range those using nucleic-acid-based technologies, which led by wealthy Western Therefore, platforms, though less from biotechnological standpoint, proven be extremely management SARS-CoV-2.

Language: Английский

Exigency of Plant-Based Vaccine against COVID-19 Emergence as Pandemic Preparedness

Vaccines, Journal Year: 2023, Volume and Issue: 11(8), P. 1347 - 1347

Published: Aug. 9, 2023

After two years since the declaration of COVID-19 as a pandemic by World Health Organization (WHO), more than six million deaths have occurred due to SARS-CoV-2, leading an unprecedented disruption global economy. Fortunately, within year, wide range vaccines, including pathogen-based inactivated and live-attenuated replicating non-replicating vector-based nucleic acid (DNA mRNA)-based protein-based subunit virus-like particle (VLP)-based been developed mitigate severe impacts pandemic. These vaccines proven highly effective in reducing severity illness preventing deaths. However, availability supply become issue prioritization vaccine distribution most countries. Additionally, virus continues mutate spread, questions arisen regarding effectiveness against new strains SARS-CoV-2 that can evade host immunity. The urgent need for booster doses enhance immunity has recognized. scarcity “safe effective” exacerbated inequalities terms coverage. development fallen short expectations set forth 2020 2021. Furthermore, equitable at national levels remains challenge, particularly developing In such circumstances, exigency plant virus-based apparent means overcome shortages through fast manufacturing processes enable quick convenient millions people without reliance on cold chain system. Moreover, demonstrated both safety efficacy eliciting robust cellular immunogenicity pathogens. This review aims shed light advantages disadvantages different types provide update current status plant-based fight

Language: Английский

Complete Genomic Characterization of Lumpy Skin Disease Virus Isolates from Beef Cattle in Lopburi Province, Central Thailand, during 2021–2022

Veterinary Sciences, Journal Year: 2023, Volume and Issue: 11(1), P. 10 - 10

Published: Dec. 22, 2023

Lumpy skin disease (LSD) is a viral infection that impacts the cattle industry. The most efficient approach to prevent involves utilization of live-attenuated LSD vaccines (LAVs), which stands out as successful method. However, LAVs might be subjected changes their genomes during replication increase infectivity or virulence. objective this study was monitor alterations in genetic characteristics lumpy virus (LSDV) beef following administration Lopburi Province Central Thailand. A total four samples from cases were collected non-vaccinated animals exhibited clinical symptoms two distinct districts, spanning three subdistricts within region. analyzed using real-time PCR targeting LSDV074 p32 gene, isolated, and entire genome sequences evaluated through single nucleotide polymorphisms (SNPs) analysis, phylogenetic trees assembled. investigations revealed LSDVs isolates Chai Badan district significant mutations open reading frame (ORF) 023 putative protein, while another Lam Sonthi had change untranslated region (UTR). For result, proficient diagnosis control should on genetics regular basis.

Language: Английский