Thyroid dysfunction in COVID-19

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(6), P. 336 - 348

Published: Feb. 12, 2024

Language: Английский

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Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 4, 2025

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) virus, has presented multifaceted health challenges. COVID-19 primarily targets system but also affects multiple organ systems, including endocrine system. Emerging evidence suggests interactions between thyroid function, phase of COVID-19, and prolonged symptoms known as post-COVID sequalae or long COVID. Several studies have reported that can induce dysfunction, leading to conditions such thyroiditis alterations in hormone levels. mechanisms through which SARS-CoV-2 include direct viral infection cells, thyroiditis, causes inflammation transient sustained well an excessive systemic immune response (cytokine storm). This is associated with elevated levels cytokines, IL-6, disrupt function lead nonthyroidal illness (NTIS). Medications administered during phase, corticosteroids antiviral drugs, impact actions. involvement gland COVID, postacute sequelae infection, area not defined, potential implications for understanding managing this condition. Persistent low-grade affecting over time ongoing exacerbate pre-existing conditions. Viral infections, SARS-CoV-2, trigger worsen autoimmune diseases, Hashimoto’s Graves’ disease. Long COVID may hypothalamic–pituitary–adrenal (HPA) axis, can, turn, affect hypothalamic-pituitary-thyroid (HPT) abnormal function. review was designed systematically capture recent literature on COVID-19-related dysfunction adult population, prognostic consequences effects patients A comprehensive search PubMed EMBASE databases conducted. systematic performed based Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) statement. Study quality assessed using Critical Appraisal Skills Programme (CASP). total 53 met inclusion criteria. summarises findings provides update current spectrum disorders, underscoring complex nature its far-reaching impacts human health.

Language: Английский

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Advances in Subacute Thyroiditis: Pathogenesis, Diagnosis, and Therapies

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(7)

Published: April 9, 2025

ABSTRACT Subacute thyroiditis (SAT) is an inflammatory thyroid disease that often associated with viral infections. In particular, SARS‐COV‐2 and its vaccine were found to cause SAT during the recent COVID‐19 pandemic. However, pathogenesis, clinical features, processes still need further profiling. Recently, there are new findings understanding about pathogenic mechanisms of SAT. Some HLA genes have been shown increase risk development, cytokine storms could promote progression diagnostic criteria for proposed facilitate clinicians' diagnosis when facing atypical symptoms in a manner rapidity accuracy. Plus, treatments herbal medicines recently as addition conventional steroidal drugs NSAIDs. This review will provide summary these progresses on diagnosis, therapies emphasis role variety virus pathogens, including virus.

Language: Английский

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Thyroid disorders and COVID-19: a comprehensive review of literature

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

The literature is rapidly evolving with regards to the endocrine consequences of coronavirus disease 2019 (COVID-19), including diabetes, thyroid dysfunction, adrenal and pituitary disorders. There evidence suggesting that severe acute respiratory syndrome 2 (SARS-CoV-2) infection can lead dysfunction long-term sequelae. We aimed review current propose a preventive approach based on published data since beginning COVID-19 pandemic. A comprehensive was conducted using electronic databases PubMed Google Scholar. Two authors independently used keywords "Thyroid, Hypothyroidism, Hyperthyroidism, Graves, Thyroid Eye Disease, or Thyroiditis" "Coronavirus, SARS-CoV-2 COVID-19" search these databases. screened titles abstracts for initial selection then reviewed full text relevant studies report outcomes data. selected 28 manuscripts. appears similar other viruses. It affects function resulting in non-thyroidal illness syndrome, which usually resolves spontaneously. also causes subacute thyroiditis. may trigger autoimmunity against leads autoimmune Autoimmune thyroiditis progress clinical subclinical hypothyroidism hyperthyroidism. Patients pre-existing probably have risks related adverse outcomes. Evaluation important patients. Improving efficacy treatment reduce short-term complications. https://www.crd.york.ac.uk/prospero, identifier CRD42023447994.

Language: Английский

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Hypothyroidism

Published: Jan. 1, 2025

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Potential use of sodium glucose co-transporter 2 inhibitors during acute illness: a systematic review based on COVID-19

Endocrine, Journal Year: 2024, Volume and Issue: 85(2), P. 660 - 675

Published: March 6, 2024

Abstract Objective SGLT-2i are increasingly recognized for their benefits in patients with cardiometabolic risk factors. Additionally, emerging evidence suggests potential applications acute illnesses, including COVID-19. This systematic review aims to evaluate the effects of facing illness, particularly focusing on SARS-CoV-2 infection. Methods Following PRISMA guidelines, a search PubMed, Scopus, medRxiv, Research Square, and Google Scholar identified 22 studies meeting inclusion criteria, randomized controlled trials observational studies. Data extraction quality assessment were conducted independently. Results Out included review, six reported reduced mortality DM-2 taking SGLT-2i, while two found decreased hospitalization. Moreover, one study demonstrated lower in-hospital rate under combined therapy metformin plus SGLT-2i. However, three showed neutral effect No increased developing COVID-19 was associated use patients. Prior not ICU admission need MV. The kidney injury variability, inconsistent regarding diabetic ketoacidosis. Conclusion Our reveals mixed findings efficacy While some suggest reducing hospitalizations, others report inconclusive results. Further research is needed clarify optimal usage mitigate risks, emphasizing caution clinical interpretation.

Language: Английский

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Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: June 14, 2024

Abstract Background Some previous observational studies have linked deep venous thrombosis (DVT) to thyroid diseases; however, the findings were contradictory. This study aimed investigate whether some common diseases can cause DVT using a two-sample Mendelian randomization (MR) approach. Methods MR used single nucleotide polymorphisms (SNPs) identified by FinnGen genome-wide association (GWAS) be highly associated with diseases, including autoimmune hyperthyroidism (962 cases and 172,976 controls), subacute thyroiditis (418 187,684 hypothyroidism (26,342 59,827 malignant neoplasm of gland (989 217,803 controls. These SNPs as instruments. Outcome datasets for GWAS on (6,767 330,392 controls) selected from UK Biobank data, which was obtained Integrative Epidemiology Unit (IEU) open project. The inverse variance weighted (IVW), MR-Egger median methods estimate causal between diseases. Cochran’s Q test quantify heterogeneity instrumental variables (IVs). Pleiotropy RESidual Sum Outlier (MR-PRESSO) detect horizontal pleiotropy. When relationship significant, bidirectional analysis performed determine any reverse relationships exposures outcomes. Results illustrated that slightly increased risk according IVW [odds ratio (OR) = 1.0009; p 0.024] [OR 1.001; 0.028]. According test, there no evidence in IVs. Additionally, MR-PRESSO did not pleiotropy ( 0.972). However, observed other IVW, median, regression methods. Conclusions revealed may DVT; more larger sample sizes are required draw precise conclusions.

Language: Английский

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An unusual cause of hyperthyroidism in a teenage girl

Česko-slovenská pediatrie, Journal Year: 2024, Volume and Issue: 79(Suppl.3), P. S30 - S34

Published: Dec. 1, 2024

Language: Английский

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Associations between deep venous thrombosis and thyroid diseases: A two-sample bidirectional Mendelian Randomization study

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 20, 2023

Backgrounds: In some previous observational studies, deep venous thrombosis (DVT) has been linked to thyroid diseases, but the findings are debatable. This study aimed reveal whether common diseases can causally result in DVT using two-sample Mendelian Randomization (MR) approach. Methods We did a MR that chose single nucleotide polymorphisms (SNPs) which highly associated with from FinnGen datasets as our instruments, including autoimmune hyperthyroidism (962 cases and 172,976 controls), subacute thyroiditis (418 187,684 hypothyroidism (26,342 59,827 controls) malignant neoplasm of gland (989 217,803 controls). Outcomes about (6,767 330,392 were obtained IEU open GWAS project. Inverse variance weighted (IVW), MR-Egger median used estimate causal association between diseases. Cochran’s Q test was quantify heterogeneity instrumental variables. also detected horizontal pleiotropy MR-PRESSO. When relationship significant, bidirectional randomization analysis performed determine if there reverse relationships exposures outcomes. Results The illustrated slightly raised risk IVW method[odds ratio (OR) = 1.000891; 95% confidence interval (CI):1.0001156–1.001667; p 0.0243]. Weighted showed similar association[OR 1.000984; 95%CI: 1.0000806–1.001888; 0.03278]. There no evidence variables MR-PRESSO didn’t assumed presence (p 0.972). However, point out other had method, method regression. Conclusion Our research found may cause DVT. More evidences lager samples needed draw more precise conclusions.

Language: Английский

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Symptoms and steroid dose adjustments following the Covid-19 vaccine in patients with adrenal insufficiency

Pituitary, Journal Year: 2023, Volume and Issue: 27(1), P. 61 - 69

Published: Nov. 17, 2023

Language: Английский

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