A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus DOI Creative Commons
Fatemeh Ebrahimi,

Ali Modaresi Movahedi,

Mohammad Sabbaghian

et al.

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(11)

Published: Nov. 1, 2024

ABSTRACT Background and Aims Oncogenic viruses are responsible for approximately 12% of human malignancies, influencing various cancer processes through intricate interactions with host cells. Exosomes (EXOs), nanometric‐sized microvesicles involved in cell communication, have emerged as critical mediators these interactions. This review aims to explore the mechanisms by which EXOs produced cells infected oncogenic promote growth, enhance viral transmissibility, act immunomodulators. Methods A comprehensive was conducted, focusing on recent studies highlighting facilitate potential viruses. The analysis included characterization exosomal content, such microRNAs (miRNAs) proteins, their effects tumor microenvironments immune responses. search performed using databases including PubMed, ScienceDirect, Google Scholar. MeSH keywords related EXOs, viruses, were used retrieve relevant review, systematic, research articles. Results Findings indicate that from virus‐infected carry components infection inflammation. These alter microenvironment, contributing development virus‐associated cancers. Additionally, highlights growing interest among researchers regarding implications progression role enhancing oncogenicity Conclusion findings underscore pivotal mediating suggesting targeting pathways may provide new therapeutic avenues managing Further is needed fully elucidate functional oncogenesis.

Language: Английский

War or peace: Viruses and metastasis DOI
Mobina Bayat,

Shahin Golestani,

Saeed Motlaghzadeh

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189179 - 189179

Published: Sept. 17, 2024

Language: Английский

Citations

6
SARS-CoV-2 Nsp13 Helicase Modulates miR-146a-Mediated Signaling Pathways DOI Creative Commons

Eryn Lundrigan,

Spencer M. Uguccioni,

Christine Hum

et al.

Virology, Journal Year: 2025, Volume and Issue: 606, P. 110493 - 110493

Published: March 7, 2025

Language: Английский

Citations

0
The biomarkers’ landscape of post-COVID-19 patients can suggest selective clinical interventions DOI Creative Commons
Debora Paris, Letizia Palomba,

Maria Cristina Albertini

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 15, 2023

Abstract In COVID-19 clinical symptoms can persist even after negativization also in individuals who have had mild or moderate disease. We here investigated the biomarkers that define post-COVID-19 state analyzing exhaled breath condensate (EBC) of 38 post patients and sex age-matched healthy controls via nuclear magnetic resonance (NMR)-based metabolomics. Predicted gene-modulated microRNAs (miRNAs) related to were quantified from EBC 10 controls. Finally, parameters all correlated with metabolomic data. Post-COVID-19 showed different metabolic phenotype (“metabotype”). From metabolites, by using enrichment analysis we identified miRNAs resulted up-regulated (hsa-miR146a-5p) down-regulated (hsa-miR-126-3p hsa-miR-223-3p) post-COVID-19. Taken together, our multiomics data indicate before rehabilitation are characterized persistent inflammation, dysregulation liver, endovascular thrombotic pulmonary processes, physical impairment, which should be primary targets contrast post-acute sequelae COVID-19.

Language: Английский

Citations

5
Gene expression profile of mitogen-activated kinases and microRNAs controlling their expression in HaCaT cell culture treated with lipopolysaccharide A and cyclosporine A DOI Creative Commons
Michał Wójcik, Nikola Zmarzły,

Alicja Derkacz

et al.

Cell Cycle, Journal Year: 2024, Volume and Issue: 23(3), P. 279 - 293

Published: Feb. 1, 2024

Studies indicate that mitogen-activated protein kinases (MAPKs) are activated and overexpressed in psoriatic lesions. The aim of the study was to assess changes expression pattern genes encoding MAPKs microRNA (miRNA) molecules potentially regulating their human adult low-calcium high-temperature (HaCaT) keratinocytes exposed bacterial lipopolysaccharide A (LPS) cyclosporine (CsA). HaCaT cells were treated with 1 µg/mL LPS for 8 h, followed by treatment 100 ng/mL 2, 8, or 24 h. Untreated served as controls. molecular analysis consists microarray, quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay analyses. statistical obtained results performed using Transcriptome Analysis Console STATISTICA 13.5 PL significance threshold p < 0.05. Changes profile six mRNAs: dual-specificity phosphatase (DUSP1), 4 (DUSP4), kinase 2 (MAP2K2), 7 (MAP2K7), (MAP3K2) 9 (MAPK9) cell culture drug compared control. We observed under treatment, o/ miR-34a, miR-1275, miR-3188, miR-382 changed significantly (p 0.05). demonstrated a potential relationship between DUSP1 miR-34a; DUSP4 miR-382, miR-3188; MAPK9 MAP2K7 mir-200-5p; MAP3K2 mir-200-5p, which may be subject further research context psoriasis.

Language: Английский

Citations

1
Beyond the Virus: Exploring Coinfections in the COVID-19 Pandemic DOI Open Access
Reyhaneh Rasizadeh,

E. Milani,

Parisa Shiri Aghbash

et al.

The Open Microbiology Journal, Journal Year: 2023, Volume and Issue: 17(1)

Published: Nov. 17, 2023

The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, cannot be understated. Amidst relentless focus on this viral adversary, we must not lose sight an equally formidable challenge – lurking threat bacterial coinfections that can exacerbate morbidity and mortality. Various factors, including ICU admissions, age demographics, microbiota disturbances, empirical antibiotic use, contribute to specter coinfections. Respiratory tract coinfections, often featuring Streptococcus pneumoniae, precede bacteremia urinary involvement. However, landscape in is a diverse tapestry with regional institutional variations. Unlike its counterparts, exhibits lower incidence coinfection, underscoring urgency judicious administration curb looming antimicrobial resistance. Pandemics have historically witnessed upsurge coinfection-related This comprehensive review delves into multifaceted realm bacterial, viral, fungal amidst pandemic. We scrutinize their tracts, blood, microbiota, ominous emergence drug-resistant microorganisms. In conclusion, explore nuanced treatment strategies quest effective pandemic management.

Language: Английский

Citations

2
Critical role of miR-21/exosomal miR-21 in autophagy pathway DOI
Mohamed J. Saadh,

Morug Salih Mahdi,

Omer Qutaiba B. Allela

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 257, P. 155275 - 155275

Published: March 30, 2024

Language: Английский

Citations

0
Identification and evaluation of candidate COVID-19 critical genes and medicinal drugs related to plasma cells DOI Creative Commons

Zhe Liu,

Olutomilayo Olayemi Petinrin, Nanjun Chen

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 3, 2024

Language: Английский

Citations

0
SARS-CoV-2 Vaccine Improved Hemostasis of a Patient with Protein S Deficiency: A Case Report DOI Open Access
Mohammad A Mohammad,

Alaa Malik,

Lekha Thangada

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10717 - 10717

Published: Oct. 5, 2024

A 16-year-old patient, while an infant, incurred right-sided hemiparesis and had difficulty breast feeding. She was later diagnosed with a neonatal stroke her genetic testing showed missense mutation in PROS1 (Protein S) gene. Both grandfather father, but not mother, hereditary Protein S (PS) deficiency. The patient prescribed any mediation due to young age frequently checked by physician. patient’s plasma first collected at the of 13, isolated from father were analyzed aPTT, thrombin generation, enzyme-linked immunosorbent assays. These analyses low PS activity clotting time associated During COVID-19 pandemic, received Pfizer vaccination dose 2021, followed booster 2022. samples 8 weeks post-immunization, after which parameters improved for up 6 months following vaccination. significant reduction generation aPTT time. Mass spectrometry analysis revealed that antithrombin-III level significantly higher post-vaccination, both FXII levels lowered compared father. To our knowledge, this is report document can lower risk thrombosis inherited thrombophilia. Although effect observed on single mutation, it would be interesting investigate vaccinations other

Language: Английский

Citations

0
A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus DOI Creative Commons
Fatemeh Ebrahimi,

Ali Modaresi Movahedi,

Mohammad Sabbaghian

et al.

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(11)

Published: Nov. 1, 2024

ABSTRACT Background and Aims Oncogenic viruses are responsible for approximately 12% of human malignancies, influencing various cancer processes through intricate interactions with host cells. Exosomes (EXOs), nanometric‐sized microvesicles involved in cell communication, have emerged as critical mediators these interactions. This review aims to explore the mechanisms by which EXOs produced cells infected oncogenic promote growth, enhance viral transmissibility, act immunomodulators. Methods A comprehensive was conducted, focusing on recent studies highlighting facilitate potential viruses. The analysis included characterization exosomal content, such microRNAs (miRNAs) proteins, their effects tumor microenvironments immune responses. search performed using databases including PubMed, ScienceDirect, Google Scholar. MeSH keywords related EXOs, viruses, were used retrieve relevant review, systematic, research articles. Results Findings indicate that from virus‐infected carry components infection inflammation. These alter microenvironment, contributing development virus‐associated cancers. Additionally, highlights growing interest among researchers regarding implications progression role enhancing oncogenicity Conclusion findings underscore pivotal mediating suggesting targeting pathways may provide new therapeutic avenues managing Further is needed fully elucidate functional oncogenesis.

Language: Английский

Citations

0