Development and validation of a novel mortality risk stratification simplified scoring scale for severe fever with thrombocytopenia syndrome

Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Metabolic Fingerprint in Childhood Acute Lymphoblastic Leukemia

Diagnostics, Journal Year: 2024, Volume and Issue: 14(7), P. 682 - 682

Published: March 24, 2024

Introduction: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood malignancy. Despite high cure rates, several questions remain regarding predisposition, response to treatment, and prognosis of disease. The role intermediary metabolism in individualized mechanistic pathways disease unclear. We have hypothesized that children with any (sub)type ALL a distinct metabolomic fingerprint at diagnosis when compared: (i) control group; (ii) different ALL; (iii) end induction treatment. Materials Methods: In this prospective case–control study (NCT03035344), plasma urinary metabolites were analyzed 34 before beginning (D0) treatment (D33). Their metabolic was defined by targeted analysis 106 compared an equal number matched controls. Multivariate univariate statistical analyses performed using SIMCAP scripts under R programming language. Results: Metabolomic showed changes patients controls on both D0 D33. within patient group differed significantly between common B-ALL pre-B D33, reflecting effect further identified major components dysregulation, indicating shifts fatty acid synthesis, transfer oxidation, amino glycerophospholipid metabolism, glutaminolysis/TCA cycle. Conclusions: type time point-specific alterations observed pediatric are particular interest as they may offer potential for discovery new prognostic biomarkers therapeutic targets.

Language: Английский

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Aspartate aminotransferase to platelet ratio correlates with poor prognosis and metabolic alterations in Dabie bandavirus infection

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease a high mortality rate caused by Dabie bandavirus. The aspartate aminotransferase to platelet ratio index (APRI) biomarker of liver injury and inflammation. This study aimed examine the correlation between APRI SFTS prognosis using clinical data analysis attempt explain its prognostic significance through metabolic analysis. Data from hospitalized patients confirmed diagnosis virus infection at Wuhan Union Hospital were retrospectively collected. low groups 1:1 matched propensity score matching (PSM) Fresh plasma was collected on admission used for tests. A total 617 who met inclusion criteria selected Survival revealed that (> 35.3) had substantially higher death than those (≤ 35.3). Receiver operating characteristic showed predictive performance 0.77, 95% CI 0.73-0.80, which superior NLR (area under curve (AUC): 0.65), platelet-to-lymphocyte (AUC: 0.54), systemic immune-inflammation 0.58). value more substantial after PSM before PSM. Metabolomic testing identified several differential serum metabolites, alanine, aspartate, glutamate, glycerophospholipid, tryptophan metabolism being most important pathways. associated relatively in SFTS, survival outcome well-recognized inflammatory scores. Alanine, glutamate are involved progression SFTS.

Language: Английский

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Metabolic Profiling Reveals Potential Prognostic Biomarkers for SFTS: Insights into Disease Severity and Clinical Outcomes

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 228 - 228

Published: March 27, 2025

Background/Objectives: Severe fever with thrombocytopenia syndrome (SFTS) is a viral infection primarily found in Asia, case fatality rate of about 10%. Despite its increasing prevalence, the underlying pathogenic mechanisms remain poorly understood, limiting development effective therapeutic interventions. Methods: We employed an untargeted metabolomics approach using liquid chromatography-mass spectrometry (LC-MS) to analyze serum samples from 78 SFTS patients during acute phase their illness. Differential metabolic features between survival and fatal cases were identified through multivariate statistical analysis. Furthermore, we constructed prognostic model based on these biomarkers predict disease severity. Results: Significant alterations observed four key pathways: sphingolipid metabolism, biosynthesis phenylalanine, tyrosine, tryptophan, primary bile acid biosynthesis, phenylalanine metabolism. Elevated levels phenyllactic isocitric strongly associated adverse outcomes demonstrated high discriminatory power distinguishing survivors. The incorporating achieved sensitivity 75% specificity 90% predicting Conclusions: Our findings highlight pivotal role dysregulation pathogenesis suggest that targeting specific pathways could open new avenues for development. identification provides valuable tool early risk stratification timely clinical intervention, potentially improving patient outcomes.

Language: Английский

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Evolving therapeutic strategies for severe fever with thrombocytopenia syndrome: from past to future

Therapeutic Advances in Infectious Disease, Journal Year: 2025, Volume and Issue: 12

Published: May 1, 2025

Severe fever with thrombocytopenia syndrome (SFTS) is a hemorrhagic caused by Bandavirus dabieense. SFTS was first identified in China 2009 and has been reported since then neighboring countries regions. The clinical manifestations of include fever, thrombocytopenia, leukocytopenia are often accompanied gastrointestinal symptoms bleeding. In severe cases, patients experience life-threatening immune damage cytokine storms. Despite nearly 15 years its discovery, no effective vaccine approved. However, significant progress achieved elucidating the mechanisms host responses, implementation various therapeutic agents. This article provides comprehensive review commonly utilized treatments supported current evidence. Favipiravir advantages over ribavirin terms viral clearance prognosis. Conventional immunomodulators like interferon, intravenous immunoglobulin, glucocorticoids have limited effects may even worsen conditions, whereas novel such as tocilizumab ruxolitinib shown potential for improving Prophylactic platelet transfusions neither prevent bleeding nor improve outcomes. Additionally, plasma exchange, calcium channel blockers, arginine can laboratory values expedite clearance. future, screening Food Drug Administration-approved drugs conducting multiomics analyses lead to discovery new options.

Language: Английский

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Differential short-term and long-term metabolic and cytokine responses to infection of severe fever with thrombocytopenia syndrome virus

Metabolomics, Journal Year: 2024, Volume and Issue: 20(4)

Published: July 27, 2024

Language: Английский

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