Epidemiological and Clinical Characteristics, Transmissibility, and Associated Factors of HAdV in Wuhan, China (2023-2024): Insights from a Multi-Center Public Health Surveillance System DOI
Tianmu Chen,

Yunkang Zhao,

Banghua Chen

et al.

Published: May 8, 2025

Abstract Background Human adenovirus is not a notifiable disease in China, making surveillance essential, especially as respiratory illnesses rise after COVID-19. This study explores its characteristics and the factors affecting incidence. Methods From 2023 to 2024, we used multi-center system Wuhan identify human infections. We conducted descriptive analyses examine characteristics, mathematical models estimate transmissibility, applied generalized additive analyze associated factors. Two prediction were forecast future epidemics. Results Here show that 2.17% of 683,868 individuals infections; 53.59% required hospitalization, fewer than 1% severe or fatal. Infections more common males (1.70%-3.69% vs. 1.60%-3.08%) children ≤14 years (610.96 <100.00 per 100,000), while hospitalized, illness death occurred mainly older adults (91.94% <60.00% for hospitalized; 2.86% <2.00% severe; 1.23% <0.05% death). Seasonal peaks observed winter spring, with symptoms including fever cough (>49.00%). The 0.35% developed acute hepatitis. basic reproduction number ( ) was 0.91, median real-time transmission () 1.00. Higher incidences colder weather, stronger winds, higher air pollution (NO₂, O3), internet search activity, population mobility. Forecasts suggest several infection waves beginning mid-2024, peaking early 2025. Conclusions Although prevalence transmissibility remain low, can cause serious outcomes elderly. Ongoing vaccine development before during epidemic seasons are essential reduce impact.

Language: Английский

Epidemiological and Clinical Characteristics, Transmissibility, and Associated Factors of HAdV in Wuhan, China (2023-2024): Insights from a Multi-Center Public Health Surveillance System DOI
Tianmu Chen,

Yunkang Zhao,

Banghua Chen

et al.

Published: May 8, 2025

Abstract Background Human adenovirus is not a notifiable disease in China, making surveillance essential, especially as respiratory illnesses rise after COVID-19. This study explores its characteristics and the factors affecting incidence. Methods From 2023 to 2024, we used multi-center system Wuhan identify human infections. We conducted descriptive analyses examine characteristics, mathematical models estimate transmissibility, applied generalized additive analyze associated factors. Two prediction were forecast future epidemics. Results Here show that 2.17% of 683,868 individuals infections; 53.59% required hospitalization, fewer than 1% severe or fatal. Infections more common males (1.70%-3.69% vs. 1.60%-3.08%) children ≤14 years (610.96 <100.00 per 100,000), while hospitalized, illness death occurred mainly older adults (91.94% <60.00% for hospitalized; 2.86% <2.00% severe; 1.23% <0.05% death). Seasonal peaks observed winter spring, with symptoms including fever cough (>49.00%). The 0.35% developed acute hepatitis. basic reproduction number ( ) was 0.91, median real-time transmission () 1.00. Higher incidences colder weather, stronger winds, higher air pollution (NO₂, O3), internet search activity, population mobility. Forecasts suggest several infection waves beginning mid-2024, peaking early 2025. Conclusions Although prevalence transmissibility remain low, can cause serious outcomes elderly. Ongoing vaccine development before during epidemic seasons are essential reduce impact.

Language: Английский

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