Genetics of Long COVID: Exploring the Molecular Drivers of Persistent Pulmonary Vascular Disease Symptoms

Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(1), P. 15 - 15

Published: Feb. 13, 2025

Background/ Objectives: Long COVID or post-acute sequelae of SARS-CoV-2 infection (PASC) are symptoms that manifest despite passing the acute phase. These manifestations encompass a wide range symptoms, most common being fatigue, shortness breath, and cognitive dysfunction. Genetic predisposition is clearly involved in susceptibility individuals to developing these persistent variation severity forms. This review summarizes role genetic factors gene polymorphisms development major pulmonary vascular disorders associated with long COVID. Methods: A comprehensive current literature was conducted examine contributions complications following infection. Studies investigating linked hypertension, thromboembolism, endothelialitis were reviewed summarized. Results: Findings show specific variants contribute increased patients. Variants endothelial dysfunction, coagulation pathways, inflammatory responses have been implicated hypertension thromboembolic events. predispositions influencing integrity immune appear influence disease progression. Conclusions: Understanding mechanisms could pave way for targeted therapeutic interventions alleviate burden on patients experiencing

Language: Английский

The interleukin gene landscape: understanding its influence on inflammatory mechanisms in apical periodontitis

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 7, 2025

Language: Английский