Elevated serum Homocysteine levels a possible non-invasive diagnostic biomarker in patients with Non-alcoholic fatty liver disease DOI Open Access

Panchami H.K.,

M Kumara,

Varsha D. Shiragannanavar

et al.

International Journal of Health & Allied Sciences, Journal Year: 2023, Volume and Issue: 11(2)

Published: March 28, 2023

Lack of independent biomarkers is very much evident in NAFLD. Early detection NAFLD difficult due to the absence specific diagnostic and prognostic markers clinical symptoms. We retrospectively collected information patients hospitalised with diagnosis metabolic syndrome during 2019-2020 using tertiary care hospital inpatient sample database evaluated changes their serum homocysteine levels. found that 59.063% male population 41.667% female had increased homocysteine. This shows elevated can act as a potential biomarker for

Language: Английский

Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease DOI Creative Commons
Emmanouil Nychas, Andrea Marfil-Sánchez, Xiuqiang Chen

et al.

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 14, 2025

The pathogenesis of non-alcoholic fatty liver disease (NAFLD) with a global prevalence 30% is multifactorial and the involvement gut bacteria has been recently proposed. However, finding robust bacterial signatures NAFLD great challenge, mainly due to its co-occurrence other metabolic diseases. Here, we collected public metagenomic data integrated taxonomy profiles in silico generated community outputs, detailed clinical data, 1206 Chinese subjects w/wo diseases, including (obese lean), obesity, T2D, hypertension, atherosclerosis. We identified highly specific microbiome through building accurate machine learning models (accuracy = 0.845–0.917) for high portability (generalizable) low prediction rate (specific) when applied as well approach involving differential co-abundance ecological networks. Moreover, using these coupled further mediation analysis dependency modeling, propose synergistic defined microbial consortia associated phenotype overweight lean individuals, respectively. Our study reveals offers more realistic microbiome-therapeutics over individual species this complex disease.

Language: Английский

Citations

1
Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation DOI Creative Commons
Shuai Yuan, Jie Chen, Lintao Dan

et al.

American Journal of Clinical Nutrition, Journal Year: 2022, Volume and Issue: 116(6), P. 1595 - 1609

Published: Oct. 7, 2022

Language: Английский

Citations

28
Identification of gut microbiome features associated with host metabolic health in a large population-based cohort DOI Creative Commons
Ayya Keshet, Eran Segal

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 29, 2024

Language: Английский

Citations

5
Serum Metabolic Signatures and MetalnFF Diagnostic Score for Mild and Moderate Metabolic Dysfunction-Associated Steatotic Liver Disease DOI
Yang Chen, Y. Wang, Tuo Shen

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 260, P. 116772 - 116772

Published: Feb. 25, 2025

Language: Английский

Citations

0
An Evaluation of Soybean Protein Concentrate as a Replacement for Fish Meal with Methionine Supplementation in Diets for Hybrid Sturgeon (Acipenser baerii ♀ × A. schrenckii ♂) DOI Creative Commons
Zhaolin Li,

Kai Xie,

Jiufeng Gu

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(6), P. 787 - 787

Published: March 10, 2025

Soy protein concentrate (SPC) is a cost-effective alternative to fish meal (FM) in aquaculture, but its deficiency essential amino acids, particularly methionine, limits application. This study evaluated the effects of methionine supplementation on growth, liver and intestinal health, muscle quality hybrid sturgeon (Acipenser baerii ♀ × A. schrenckii ♂) fed SPC-based diets. Four diets were formulated: an FM control diet, SPC supplemented with 0% (M0), 0.25% (M2.5), 0.50% (M5) methionine. Replacing without (M0) significantly reduced weight gain efficiency ratio (PER) while increasing feed conversion (FCR) hepatic lipid accumulation. Methionine restored growth performance, PER, texture levels comparable group. Intestinal enzyme activities (lipase trypsin), villus height, goblet cell counts improved M5 Gene expression analysis showed that upregulated tight junction genes (claudin1, occludin) anti-inflammatory (tgfβ, lysozyme) reducing pro-inflammatory cytokines (il1β, il8). In liver, oxidative stress markers such as malondialdehyde (MDA) antioxidant (SOD, CAT) optimizing metabolism, evidenced by lower triglyceride (TG) total cholesterol (TC) levels. Muscle increased hardness, chewiness, fiber density compared M0. conclusion, at effectively mitigates negative SPC, improving sturgeon.

Language: Английский

Citations

0
Association between homocysteine and nonalcoholic fatty liver disease: Mendelian randomisation study DOI
Liwan Fu, Yuquan Wang, Yue‐Qing Hu

et al.

European Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 53(3)

Published: Oct. 28, 2022

Many observational studies explore the relationship between homocysteine (Hcy) and nonalcoholic fatty liver disease (NAFLD), whereas causality of this association remains uncertain, especially in European populations. We performed a bidirectional Mendelian randomisation study to elucidate causal Hcy NAFLD. Furthermore, we explored with enzymes, including alkaline phosphatase (ALP), alanine aminotransferase (ALT) aspartate (AST).Two-sample was conducted. Summary statistics for were obtained from genome-wide (GWAS) meta-analysis comprising 44,147 subjects. Summary-level data NAFLD acquired GWAS 8434 cases 770,180 noncases another 1483 17,781 noncases. three enzymes available UK Biobank.Genetic associations concentrations observed. Genetically predicted higher consistently associated an increased risk two sources. The combined odds ratio 1.25 (95% confidence interval [CI], 1.05-1.45) per SD increase concentrations. showed significant ALP (Beta .69; 95% CI, 0.04-1.34), ALT 0.56; 0.15-0.97) AST levels .57; 0.10-1.04). Genetic liability not concentrations.This has clinical implications as it indicates that relevant may play role

Language: Английский

Citations

12
Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial DOI Creative Commons

Mohamad Reza Molaqanbari,

Shadi Zarringol,

Hamid Reza Talari

et al.

Advanced Biomedical Research, Journal Year: 2023, Volume and Issue: 12(1)

Published: April 1, 2023

Previous evidence revealed an association between folate deficiency and non-alcoholic fatty liver disease (NAFLD). This study is the first one investigating effects of folic acid on hepatic steatosis grade, enzymes, insulin resistance, lipid profile in NAFLD cases.Sixty-six participants with were allocated randomly to take either a placebo or oral tablet (1 mg) daily basis within eight weeks. Serum folate, homocysteine, glucose, aminotransferases, insulin, homeostasis model assessment resistance (HOMA-IR), lipids assessed. Ultrasonography was used for assessing grade.The serum alanine transaminase, grade steatosis, aspartate transaminase significantly decreased both groups; however, between-group comparison not statistically significant. Of note, decrease ALT more pronounced compared group (-5.45 ± 7.45 vs. -2.19 8.6 IU/L). The homocysteine after receiving (-0.58 3.41 +0.4 3.56 μmol/L; adjusted P = 0.054). Other outcomes did change.Supplementation mg/d) weeks among cases change levels profile. However, it able prevent increase placebo. Conducting further research suggested longer duration different doses acid, genotypes methylenetetrahydrofolate reductase polymorphism, patients.

Language: Английский

Citations

7
Associations of serum betaine with blood pressure and hypertension incidence in middle-aged and older adults: a prospective cohort study DOI

Rong-Zhu Huang,

Jing-fei Ma,

Si Chen

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(10), P. 4881 - 4890

Published: Jan. 1, 2023

The impact of betaine on the development hypertension remains unclear, and prospective data are sparse. We aimed to investigate association serum with repeated measurements blood pressure (BP) incidence. This study was based Guangzhou Nutrition Health Study (GNHS), a community-based cohort in China. Baseline measured by high-performance liquid chromatography-tandem mass spectrometry. BP status were assessed at baseline 3-year intervals. Linear mixed-effects models (LMEMs) used analyze longitudinal (n = 1996). Cox proportional hazard evaluate incidence 1339). LMEMs showed that compared lowest quartile group, higher groups had lower systolic (SBP), diastolic (DBP) pulse (all P-trend < 0.05). Each standard deviation (16.3 μmol L-1) increase associated -0.92 (-1.52, -0.32) mmHg SBP, -0.49 (-0.84, -0.13) DBP -0.43 (-0.81, -0.05) pressure. During median follow-up 9.2 years, 371 incident cases identified. Serum risk only when comparing third level (HR, 0.74; 95% CI, 0.56-0.99). A nonlinear between found (P-nonlinear 0.040). below 54.5 L-1. Our findings suggested favorable middle-aged older Chinese adults. Higher concentrations related people relatively low concentrations.

Language: Английский

Citations

6
Serum S-adenosylhomocysteine, rather than homocysteine, is associated with hepatocellular carcinoma survival: a prospective cohort study DOI

Maierhaba Wusiman,

Siyu Huang, Zhao-Yan Liu

et al.

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 120(3), P. 481 - 490

Published: July 16, 2024

Language: Английский

Citations

2
High dietary methionine intake may contribute to the risk of nonalcoholic fatty liver disease by inhibiting hepatic H2S production DOI
Yuhui Yang, Manman Lu, Yuncong Xu

et al.

Food Research International, Journal Year: 2022, Volume and Issue: 158, P. 111507 - 111507

Published: June 15, 2022

Language: Английский

Citations

10