Exploring the Cross-Sectional Association between Hypothyroidism and Circadian Syndrome: Insights from NHANES 2007-2012 DOI

Ahmed Arabi,

Humam Emad Rajha,

Osama Alkeilani

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Background Circadian Syndrome (CircS) encompasses a range of cardiometabolic risk factors that contribute to an increased susceptibility cardiovascular diseases and type 2 diabetes. Understanding the underpin CircS is essential. This study primarily aims examine association between hypothyroidism in adults. A secondary analysis compares this with Metabolic (MetS). Additionally, dose-response relationship serum free thyroxine (FT4) levels probability explored. Methods cross-sectional includes 4,050 NHANES participants (2007–2012). Hypothyroidism was classified into (1) drug-managed, (2) non-drug managed (NDM) primary, (3) NDM central hypothyroidism, based on self-reported medication use TSH/FT4 levels. defined as having ≥ 5 its eight components, including MetS criteria, depression, short sleep, non-alcoholic fatty liver disease. Results Our results showed significantly associated (OR: 1.58, 95% CI 1.26–1.98) 1.19, 1.01–1.42). An inverse, non-linear FT4 observed. Conclusions The underscore significant MetS, inversely related probability. These findings highlight hypothyroidism’s potential role pathogenesis prevention.

Language: Английский

Intake or Blood Levels of Magnesium and Risk of Metabolic Syndrome: A Meta-Analysis of Observational Studies DOI Open Access
Youngyo Kim, Youjin Je

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1667 - 1667

Published: May 14, 2025

Background/Objectives: The association between magnesium and metabolic syndrome has not been comprehensively examined. We conducted a meta-analysis to quantitatively evaluate the intake blood levels of syndrome. Methods: searched PubMed, Scopus, ISI Web Science databases identify studies reporting an up April 2025. To pool effect sizes on according magnesium, random effects model was used. Results: Twenty-seven publications including 95,933 participants were included in meta-analysis. relative risk summary for highest versus lowest 0.79 (95% confidence interval [CI]: 0.71–0.88) prospective cohort studies. In cross-sectional studies, inversely associated with (odds ratio = 0.61; 95% CI: 0.39–0.94). High (effect estimate 0.53; 0.37–0.76). Conclusions: present indicated that Regarding syndrome, significant inverse found, but interpretation cautious due observed high heterogeneity. status needs be confirmed further

Language: Английский

Citations

0
Exploring the Cross-Sectional Association between Hypothyroidism and Circadian Syndrome: Insights from NHANES 2007-2012 DOI

Ahmed Arabi,

Humam Emad Rajha,

Osama Alkeilani

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Background Circadian Syndrome (CircS) encompasses a range of cardiometabolic risk factors that contribute to an increased susceptibility cardiovascular diseases and type 2 diabetes. Understanding the underpin CircS is essential. This study primarily aims examine association between hypothyroidism in adults. A secondary analysis compares this with Metabolic (MetS). Additionally, dose-response relationship serum free thyroxine (FT4) levels probability explored. Methods cross-sectional includes 4,050 NHANES participants (2007–2012). Hypothyroidism was classified into (1) drug-managed, (2) non-drug managed (NDM) primary, (3) NDM central hypothyroidism, based on self-reported medication use TSH/FT4 levels. defined as having ≥ 5 its eight components, including MetS criteria, depression, short sleep, non-alcoholic fatty liver disease. Results Our results showed significantly associated (OR: 1.58, 95% CI 1.26–1.98) 1.19, 1.01–1.42). An inverse, non-linear FT4 observed. Conclusions The underscore significant MetS, inversely related probability. These findings highlight hypothyroidism’s potential role pathogenesis prevention.

Language: Английский

Citations

0