Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
21(4)
Published: April 1, 2025
Abstract
INTRODUCTION
Regional
brain
iron
dyshomeostasis
is
observed
in
cerebral
small
vessel
disease
(cSVD)
and
other
neurodegeneration
processes.
However,
its
spatial
patterns,
cognitive
impact,
underlying
pathological
mechanisms
remain
unclear.
METHODS
Voxel‐based
analysis
of
quantitative
susceptibility
mapping
(QSM)
was
used
to
detect
regional
changes,
their
correlations
with
function
were
assessed
using
linear
regression.
We
combined
the
microarray
dataset
from
Allen
Human
Brain
Atlas
(AHBA)
explore
deposition
patterns.
RESULTS
A
total
87
cSVD
patients
80
controls
included
study.
Increased
QSM
values
bilateral
putamen
caudate
associated
decline
cSVD.
Gene
set
enrichment
revealed
gene
sets
related
central
nervous
system
integrity.
DISCUSSION
Iron
deep
gray
matter
may
indicate
changes
could
be
linked
disruption
structural
functional
Highlights
values,
indicating
focal
deposition,
(cSVD).
concentration
nuclei
impairment
patients.
Imaging
transcriptomics
suggests
that
cSVD‐related
integrity
brain.
An
open‐source
script
for
imaging
focusing
on
expression
developed
proposed.
Frontiers in Neurology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 23, 2025
To
systematically
evaluate
the
diagnostic
value
of
diffusion
tensor
imaging
(DTI)
for
mild
cognitive
impairment
(MCI)
based
on
Meta-analysis.
Databases
including
PubMed,
Web
Science,
Cochrane
Library,
Embase,
China
National
Knowledge
Infrastructure
(CNKI),
Wanfang
and
VIP
database
were
searched
literature
use
DTI
in
studying
MCI.
The
search
was
conducted
from
inception
each
up
to
February
20,
2024.
Literature
screened
predefined
inclusion
exclusion
criteria,
relevant
data
extracted,
quality
included
studies
assessed
using
QUADAS-2
tool.
Heterogeneity
evaluated
Q-test
I2
statistics.
Fractional
anisotropy
(FA)
values
different
brain
regions
(frontal
lobe,
parietal
temporal
occipital
fornix,
hippocampus,
parahippocampal
gyrus,
posterior
cingulum,
limb
internal
capsule,
uncinate
fasciculus,
inferior
fronto-occipital
superior
longitudinal
genu
splenium
corpus
callosum)
extracted
MCI
normal
control
(NC)
groups.
Meta-analysis
software
(Review
Manager
5.4)
used
perform
a
pooled
analysis
eligible
obtain
weighted
mean
difference
(WMD)
95%
confidence
interval
(95%
CI).
A
total
76
(41
English
35
Chinese).
overall
WMD
its
CI
-0.03
[-0.04,
-0.03],
with
statistically
significant
differences
all
except
lobe
capsule.
technology
can
identify
microstructural
damage
white
matter
patients,
which
holds
implications
early
diagnosis
intervention.
NeuroImage Clinical,
Journal Year:
2024,
Volume and Issue:
43, P. 103629 - 103629
Published: Jan. 1, 2024
While
mechanical
thrombectomy
(MT)
achieves
restoration
of
cerebral
blood
flow
to
the
area
at
risk
in
patients
with
acute
ischemic
stroke
(AIS),
influx
may
exacerbate
blood–brain
barrier
(BBB)
disruption
and
extravasation
across
BBB,
it
therefore
remains
unclear
how
reperfusion
impacts
integrity.
In
this
study,
we
use
diffusion-prepared
pseudocontinuous
ASL
(DP-pCASL)
Neurite
Orientation
Dispersion
Density
Imaging
(NODDI)
sequence
measure
water
exchange
rate
(kw)
who
underwent
either
MT
or
medical
management
determine
its
impact
on
brain
tissue
microstructure
order
elucidate
BBB
complex
We
prospectively
enrolled
21
AIS
treated
our
institution
from
10/2021
6/2023
MR
imaging
a
3.0-Tesla
scanner.
Patients
DP-pCASl
NODDI
addition
standard
protocol
which
generated
(CBF),
arterial
transit
time
(ATT),
(kw),
orientation
dispersion
index
(ODI),
intracellular
volume
fraction
(ICVF),
free
(FWF)
parametric
maps.
Of
patients,
11
10
were
non-operatively.
The
average
age
NIHSS
for
cohort
non-MT
cohorts
69.3
±
16.6
years
old
15.0
(12.0–20.0),
70.2
10.7
(p
=
0.882)
6.0
(3.8–9.0,
p
0.003)
respectively.
CBF,
ATT,
kw
infarcted
territory
38.2
(18.4–59.6),
1347.6
(1182.5–1842.3),
107.8
(79.2–140.1)
ROI
16.0
(8.8–36.6,
0.036),
1090.8
(937.1–1258.9,
0.013),
89.7
(68.0–122.7,
0.314)
Linear
regression
analysis
showed
increasing
CBF
0.008)
undergoing
0.048)
significant
predictors
increased
kw.
Using
multimodal
non-contrast
MRI
protocol,
demonstrate
that
kw,
suggesting
better
functioning
complex.
Higher
suggests
less
cohort.
BMC Neurology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 17, 2024
Synaptic
degeneration,
axonal
injury,
and
white
matter
disintegration
are
among
the
pathological
events
in
Alzheimer's
disease
(AD),
for
which
growth-associated
protein
43
(GAP-43)
diffusion
tensor
imaging
(DTI)
could
be
an
indicator.
In
this
study,
cerebrospinal
fluid
(CSF)
GAP-43
clinical
trajectories
their
association
with
progression
AD
hallmarks
microstructural
changes
were
evaluated.
Journal of Alzheimer s Disease,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
Background
Quantitative
susceptibility
mapping
(QSM)
is
pivotal
for
analyzing
neurodegenerative
diseases.
However,
accurate
hippocampal
segmentation
remains
a
challenge.
Objective
This
study
introduces
method
extracting
magnetic
values
using
convolutional
neural
network
(CNN)
model
referred
to
as
3D
residual
UNET.
Methods
The
was
pre-trained
on
whole
QSM
images
and
segmentations
from
T1-weighted
of
297
patients
with
Alzheimer's
disease
mild
cognitive
impairment.
Fine-tuning
conducted
through
manually
annotated
the
60
patients.
performance
assessed
Dice
similarity
coefficient
(DSC)
Pearson
correlation
coefficient.
Results
developed
applied
another
98
patients,
49
AD
impairment
(MCI),
between
volume
evaluated.
mean
DSC
0.716
±
0.045.
derived
manual
CNN
0.983.
−0.252
(
p
=
0.012)
left
side
−0.311
0.002)
right.
Conclusions
UNET
enhances
analysis
precision
QSM,
which
capable
accurately
susceptibility.
