Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

---

Future of Magnetic Sensors Applications in Early Prediction of Cardiac Health Status

Current Problems in Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 103022 - 103022

Published: Feb. 1, 2025

Language: Английский

---

White matter injuries mediate brain age effects on cognitive function in cerebral small vessel disease

Neuroradiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

This study aims to investigate the potential effect of compromised structural integrity on cerebral aging and cognitive function in small vessel disease (CSVD). Fifty-five CSVD patients 42 controls underwent three-dimensional T1-weighted imaging diffusion tensor imaging. Relative brain age (RBA) was computed assess aging. Variables included cortical thickness, volume, white matter hyperintensity (WMH) peak width skeletonized mean diffusivity (PSMD), ventricular choroid plexus volume. Mini-Mental State Examination (MMSE) conducted general cognition. Trail Making Test (TMT) Auditory Verbal Learning were administered evaluate executive episodic memory, respectively. Mediation analysis multivariate linear regression with interaction terms performed explore differential impacts RBA between controls. significantly increased compared (p < 0.001). White injuries as assessed PSMD (mediation magnitude: 41.1%) WMH volume 56.9%) mediated relationship pathologies Higher correlated poorer scores MMSE, TMT-A, TMT-B 0.01). Additionally, 57.8% 48.3% 28.8% TMT-B) 55.1% MMSE) 0.05). play a critical role decline patients.

Language: Английский

---

Deep learning-driven pulmonary artery and vein segmentation reveals demography-associated vasculature anatomical differences

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 6, 2025

Pulmonary artery-vein segmentation is critical for disease diagnosis and surgical planning. Traditional methods rely on Computed Tomography Angiography (CTPA), which requires contrast agents with potential health risks. Non-contrast CT, a safer more widely available approach, however, has long been considered impossible this task. Here we propose High-abundant Artery-vein Segmentation (HiPaS), enabling accurate across both non-contrast CT CTPA at multiple resolutions. HiPaS integrates spatial normalization an iterative strategy, leveraging lower-level vessel segmentations as priors higher-level segmentations. Trained multi-center dataset comprising 1073 volumes manual annotations, achieves superior performance (dice score: 91.8%, sensitivity: 98.0%) demonstrates non-inferiority compared to CTPA. Furthermore, enables large-scale analysis of 11,784 participants, revealing associations between abundance sex, age, diseases, under lung-volume control. represents promising, non-invasive approach clinical diagnostics anatomical research.

Language: Английский

---

Choroid plexus enlargement correlates with cognitive impairment and brain atrophy in patients with mood disorders

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 379, P. 370 - 378

Published: March 13, 2025

Language: Английский

---

Glymphatic function and choroid plexus volume is associated with systemic inflammation and oxidative stress in major depressive disorder

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: 128, P. 266 - 275

Published: April 11, 2025

Language: Английский

---

Glymphatic Dysfunction as a Biomarker for Post-stroke Cognitive Impairment

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Ischemic stroke impacts glymphatic function, but its role in prognosis remains unclear. This study evaluated function 146 participants, including non-stroke (healthy controls, n = 48; nonvascular cognitive impairment patients, 47) and ischemic cohorts (n 51). The bilateral diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index, choroid plexus (CP), (PVS) volume ratio, which represent system, were compared across two between pre-rehabilitation (Time 1) 30 days post-rehabilitation 2). Post-stroke (PSCI) was characterized as enduring deficits persisting six months after a stroke. Stroke patients exhibited significantly lower DTI-ALPS index to population (P < 0.05), with improvement observed on infarct side following rehabilitation 0.05). of at Time 1 did not predict poor outcome correlated 6-month PSCI These results indicate that diminishes partially recovering post-rehabilitation, suggest could serve predictor for

Language: Английский

---

Relevance of choroid plexus volumes in multiple sclerosis

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 8, 2025

The choroid plexus (ChP) plays a pivotal role in inflammatory processes that occur multiple sclerosis (MS). enlargement of the ChP relapsing-remitting (RRMS) is considered to be an indication disease activity and has been associated with periventricular remyelination failure. This cross-sectional study aimed identify relationship between tissue damage which occurs MS, elucidate neuroinflammation primary progressive (PPMS). volume was assessed by novel deep learning segmentation method based on structural MRI data acquired from two centers. In total, 141 RRMS 64 PPMS patients were included, along 75 healthy control subjects. addition, T1w/FLAIR ratios calculated within bands quantify microstructural assess its volume. When compared controls, volumes significantly increased RRMS, but not PPMS. normal appearing white matter (NAWM) showing gradients decreased when subjects lower radiating out lateral ventricles found A ratio NAWM inner patients. longer duration larger only Enlarged also reduced cortex lesion RRMS. Our analysis confirmed enlarged related brain suggested dynamic development as it duration. Plexus further demyelination or Furthermore, we did find PPMS, possibly indicating involvement phase MS. association cortical atrophy highlighted vulnerability structures close CSF.

Language: Английский

---

Glymphatic Dysfunction in Relapsing-Remitting Multiple Sclerosis and its Association with Brain Structural Damage and Cognitive Impairment

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: 100, P. 106531 - 106531

Published: May 14, 2025

To explore the glymphatic dysfunction in relapsing-remitting multiple sclerosis (RRMS) and its potential associations with brain structural damage, clinical disability, cognitive impairment (Co-I). The study involved 70 patients RRMS 44 healthy controls. Neurological MRI assessments were performed, performance was assessed via Brief Repeatable Battery of Neuropsychological Tests (BRB-N). assess function, we calculated choroid plexus volume (CPV) diffusion tensor imaging along perivascular spaces (DTI-ALPS) index. Multivariable linear regression analyses used to examine correlations between MRI-derived damage metrics. Additionally, utilised random forest analysis identify predictors Co-I mediating role DTI-ALPS. Patients RRMS, particularly those Co-I, exhibited a low DTI-ALPS index large CPV. A lower associated longer disease duration, greater larger lesion (LV), mean diffusivity (MD), CPV, as well fractional anisotropy (FA) (all FDR-p < 0.05). Moreover, mediated 27.21 % 43.75 CPV effects on information processing speed visuospatial memory, respectively. Random indicated that education (relative importance [RI] = 100 %), higher (RI 95.8 80.7 MD 61.3 FA 60.5 older age 54.6 EDSS score 45.4 %) are Co-I. implied may contribute indicating play key pathogenesis RRMS.

Language: Английский

---

Reduced cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: May 9, 2024

Abstract Background Parkinson’s disease is characterized by dopamine-responsive symptoms as well aggregation of α-synuclein protofibrils. New diagnostic methods assess characteristics from cerebrospinal fluid (CSF) and recent pathophysiologic mechanisms suggest that CSF circulation disruptions may precipitate retention. Here, diffusion-weighted MRI with low-to-intermediate diffusion-weightings was applied to test the hypothesis motion reduced in relative healthy participants. Methods Multi-shell diffusion weighted (spatial resolution = 1.8 × 4.0 mm) weightings ( b -values 0, 50, 100, 200, 300, 700, 1000 s/mm 2 ) over approximate kinetic range suprasellar cistern at 3 Tesla n 27; age 66 ± 6.7 years) non-Parkinson’s control 32; 68 8.9 Wilcoxon rank-sum tests were primary noise floor-corrected decay rate signal a function -value, which reflects increasing motion, within persons versus without inversely relates choroid plexus activity assessed perfusion-weighted (significance-criteria: p < 0.05). Results Consistent hypothesis, rates higher D 0.00673 0.00213 mm /s) 0.00517 0.00110 This finding preserved after controlling for sex observed posterior region 0.001). An inverse correlation between perfusion voxels (Spearman’s- r =-0.312; 0.019) observed. Conclusions identify level adults disease; strengths limitations this methodology are discussed context growing literature on flow.

Language: Английский

---