Evaluating the Monro-Kellie Doctrine: Contralateral Hemisphere Shrinkage in Intracerebral Hemorrhage Patients DOI Creative Commons

Elmira Khiabani,

Anna C. J. Kalisvaart, Cassandra M. Wilkinson

et al.

Translational Stroke Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Intracerebral hemorrhage (ICH) along with aggravating factors, such as edema, can raise intracranial pressure (ICP) to pathological levels. Diversion of some cerebrospinal fluid (CSF) and venous blood out the cranium limit ICP rises while maintaining cerebral perfusion pressure. Brain tissue itself is widely considered immutable in volume but prone distortion (e.g., midline shift). However, distal brain regions shrink acutely following ICH rodents. Tissue contraction arises from cell shrinkage increased packing density. This "tissue compliance" hypothesized be an additional mechanism rises. Here, we examined whether by how much parenchyma reduction occurs patients. We conducted a retrospective analysis on computed tomography (CT) scans 96 patients (average age 63.8 years old, 55% male) average hematoma 32.4 35.3 mL at first second scan (separated ~ 23 h), respectively. Hematoma growth (any absolute increase) occurred 44% patients, minimal significant 2.9 across all (p = 0.028). As hypothesized, contralateral hemisphere was significantly reduced 12.7 < 0.0001) between scans. unrelated shift (R2 0.012, p 0.21), which averaged 2.3 mm. These findings suggest that parenchymal may major compliance after ICH; implications for function merit further study.

Language: Английский

A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs DOI Creative Commons
Ryan M. Jones, Srdjan Cirovic, Clare Rusbridge

et al.

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 10, 2025

Cerebrospinal fluid (CSF) plays a crucial role in maintaining brain homeostasis by facilitating the clearance of metabolic waste and regulating intracranial pressure. Dysregulation CSF flow can lead to conditions like syringomyelia, hydrocephalus. This review details anatomy flow, examining its contribution within spinal cord. The integrates data from human, canine, other mammalian studies, with particular focus on brachycephalic dogs. Certain dog breeds exhibit high prevalence CSF-related due artificial selection for neotenous traits, making them valuable models studying analogous human conditions, such as Chiari-like malformation syringomyelia associated craniosynostosis. discusses anatomical features specific some impact skull cranial cervical conformation patterns, providing insights into pathophysiology potential modelling approaches these conditions.

Language: Английский

Citations

0
Impact of Massive Trauma on Brain Structures: MRI Volumetric Analysis Post-February 6 Earthquake DOI Open Access
Derya Yavuz Demiray, Fatma Dilşad Öz,

Ozan Harbali

et al.

Harran Üniversitesi Tıp Fakültesi Dergisi, Journal Year: 2025, Volume and Issue: 22(1), P. 165 - 171

Published: March 18, 2025

Background: This study aims to investigate the impact of February 6 earthquake on brain structures, particularly mood centers, using MRI volumetric analysis. Materials and Methods: In this retrospective study, 20 neurology clinic patients who were treated at a underwent both before after (2022–2023). scans analyzed within one year prior disaster. Patient data included age, gender, indications medical history. Inclusion criteria required participants have experienced headaches but excluded those with neurodegenerative diseases, head trauma, or other structural pathologies. The volBrain method was used assess total brain, white grey matter, cerebrospinal fluid, limbic system (hippocampus, parahippocampal gyrus, amygdala, hypothalamus, cingulate entorhinal cortex), pref-rontal cortex, cerebellum, thalamus via 3T T1 sequences. All had first-degree relative loss home destruction. Results: group comprised 65% women 35% men, mean age 42.15 ± 8.41 years. Significant changes observed in several regions post-earthquake. White matter volume decreased significantly (p=0.011), while CSF increased (p=0.017), showed significant reduction (p=0.025). cerebellum exhibited reductions, inclu-ding (p=0.023), as well right (p=0.021) left hemispheres (p=0.029). Similarly, demonstrated reductions (p=0.008), hemisphere (p=0.009), (p=0.010). Conversely, posterior gyrus (PCgG) increases (p=0.007), (p=0.012). Conclusions: findings reveal specific suggesting neurobi-ological effects acute stressor trauma caused by earthquake. These highlight need for further studies understand mechanisms underlying these alterations develop interventions aimed mitigating long-term such traumatic events. Keywords: Limbic system, Mrı analysis, Earthquake, Disaster, Massive Neuroimaging

Language: Английский

Citations

0
Estimation of fluid flow velocities in cortical brain tissue driven by the microvasculature DOI
Timo Koch, Kent‐André Mardal

Interface Focus, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 4, 2025

We present a modelling framework for describing bulk fluid flow in brain tissue. Within this framework, using computational simulation, we estimate velocities the grey matter parenchyma due to static or slowly varying water potential gradients—hydrostatic pressure gradients and osmotic gradients. Working with situation that experimental evidence some model parameter estimates, as point out, are presently insufficient precisely, explore feasible ranges resulting range of estimates. consider effect realistic microvascular architecture (extracted from mouse cortical matter). Although estimated small magnitude (e.g. comparison blood velocities), passive transport solutes can be relevant process when considering larger molecules transported over distances. compare velocity magnitudes filtration pulsations. Filtration lead continuous directed parenchyma, while pulsation-driven is (at least partly) reversible. For first time, vascular on distribution tissue sample ca 1 mm 3 conclude both pulsations potentially potent drivers flow.

Language: Английский

Citations

0
Spontaneous retinal venous pulsations for evaluation of intracranial pressure after endoscopic third ventriculostomy DOI Creative Commons
J.R. Boyle, William H. Miller, Andrés A. Maldonado

et al.

Medical Reports, Journal Year: 2025, Volume and Issue: 12, P. 100235 - 100235

Published: May 2, 2025

Language: Английский

Citations

0
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep DOI Creative Commons
Gerald A. Dienel, Martin Lauritzen

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 6, 2025

Language: Английский

Citations

0
Cardiac and respiratory activities induce temporal changes in cerebral blood volume, balanced by a mirror CSF volume displacement in the spinal canal DOI Creative Commons
Pan Liu, K. P. Owashi,

Heimiri Monnier

et al.

NeuroImage, Journal Year: 2024, Volume and Issue: 305, P. 120988 - 120988

Published: Dec. 25, 2024

Language: Английский

Citations

2
Evaluating the Monro-Kellie Doctrine: Contralateral Hemisphere Shrinkage in Intracerebral Hemorrhage Patients DOI Creative Commons

Elmira Khiabani,

Anna C. J. Kalisvaart, Cassandra M. Wilkinson

et al.

Translational Stroke Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Intracerebral hemorrhage (ICH) along with aggravating factors, such as edema, can raise intracranial pressure (ICP) to pathological levels. Diversion of some cerebrospinal fluid (CSF) and venous blood out the cranium limit ICP rises while maintaining cerebral perfusion pressure. Brain tissue itself is widely considered immutable in volume but prone distortion (e.g., midline shift). However, distal brain regions shrink acutely following ICH rodents. Tissue contraction arises from cell shrinkage increased packing density. This "tissue compliance" hypothesized be an additional mechanism rises. Here, we examined whether by how much parenchyma reduction occurs patients. We conducted a retrospective analysis on computed tomography (CT) scans 96 patients (average age 63.8 years old, 55% male) average hematoma 32.4 35.3 mL at first second scan (separated ~ 23 h), respectively. Hematoma growth (any absolute increase) occurred 44% patients, minimal significant 2.9 across all (p = 0.028). As hypothesized, contralateral hemisphere was significantly reduced 12.7 < 0.0001) between scans. unrelated shift (R2 0.012, p 0.21), which averaged 2.3 mm. These findings suggest that parenchymal may major compliance after ICH; implications for function merit further study.

Language: Английский

Citations

0