Evidence for reduced choroid plexus volume in the aged brain DOI Creative Commons

R Youh,

Charith Perera, Ian F. Harrison

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Background The choroid plexus plays an important role in brain homeostasis, including the active secretion of cerebrospinal fluid. Its function and structure have been reported to be affected by normal ageing. However, existing measures volume may complicated partial ( vivo MRI) tissue fixation artefacts (histology). In this study, we investigate possible changes within lateral ventricles aged mice utilising two structural MRI protocols explicitly designed for time-efficient, high-resolution imaging plexus. Methods Two sequences were utilised examine young (∼6 months) (∼24 mouse brains: 1) ultra-long echo-time T2 weighted fast-spin-echo 2) a multi-TE T2* mapping protocol. A test-retest study was performed on subset data reproducibility estimation. two-way ANOVA test determine differences groups across distinct protocols. Results Reproducibility tests showed low variability manual segmentation pipeline both statistically significant reduction found brain. This finding is concordant with previous histology studies that observed epithelial cell height ageing wide range species. Conclusions We present investigation ventricle approach based bespoke time-efficient high resolution Furthermore, these protocols, provide evidence research provides insight measurements as biomarker age-related neurologic conditions it indicates process itself does not result hypertrophy plexus, but decrease volume.

Language: Английский

The choroid plexus: a command center for brain–body communication during inflammation DOI
Huixin Xu, Christine Hehnly, Maria K. Lehtinen

et al.

Current Opinion in Immunology, Journal Year: 2025, Volume and Issue: 93, P. 102540 - 102540

Published: Feb. 27, 2025

Language: Английский

Citations

0
Evidence for reduced choroid plexus volume in the aged brain DOI Creative Commons

R Youh,

Charith Perera, Ian F. Harrison

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Background The choroid plexus plays an important role in brain homeostasis, including the active secretion of cerebrospinal fluid. Its function and structure have been reported to be affected by normal ageing. However, existing measures volume may complicated partial ( vivo MRI) tissue fixation artefacts (histology). In this study, we investigate possible changes within lateral ventricles aged mice utilising two structural MRI protocols explicitly designed for time-efficient, high-resolution imaging plexus. Methods Two sequences were utilised examine young (∼6 months) (∼24 mouse brains: 1) ultra-long echo-time T2 weighted fast-spin-echo 2) a multi-TE T2* mapping protocol. A test-retest study was performed on subset data reproducibility estimation. two-way ANOVA test determine differences groups across distinct protocols. Results Reproducibility tests showed low variability manual segmentation pipeline both statistically significant reduction found brain. This finding is concordant with previous histology studies that observed epithelial cell height ageing wide range species. Conclusions We present investigation ventricle approach based bespoke time-efficient high resolution Furthermore, these protocols, provide evidence research provides insight measurements as biomarker age-related neurologic conditions it indicates process itself does not result hypertrophy plexus, but decrease volume.

Language: Английский

Citations

0