Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders DOI Open Access
Jed W. Fahey, Hua Liu,

Holly Batt

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1353 - 1353

Published: April 15, 2025

The brain accounts for about 2% of the body’s weight, but it consumes 20% energy at rest, primarily derived from ATP produced in mitochondria. thus has a high mitochondrial density its neurons because extensive demands maintaining ion gradients, neurotransmission, and synaptic activity. is also extremely susceptible to damage dysregulation caused by inflammation (neuroinflammation) oxidative stress. Many systemic challenges can be mitigated phytochemical sulforaphane (SF), which particularly important supporting function. SF or biogenic precursor glucoraphanin, broccoli seeds sprouts, confer neuroprotective cognitive benefits via diverse physiological biochemical mechanisms. able cross blood–brain barrier as well protect it, mitigates consequences destructive neuroinflammation. It protects against neurotoxic effects environmental pollutants, combats tissue cell wrought advanced glycation end products (detoxication), supports healthy glucose metabolism. These are applicable individuals all ages, developing brains periconception infancy, cognitively, developmentally, traumatically challenged brains, those later life who suffering with multiple chronic conditions including Parkinson’s Alzheimer’s diseases.

Language: Английский

The glutathione-dependent neuroprotective activity of the blood-CSF barrier is inducible through the Nrf2 signaling pathway during postnatal development DOI Creative Commons

Nathalie Strazielle,

Karen Silva,

Emmanuel Rault

et al.

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 21, 2025

Choroid plexuses regulate the exchanges between blood and CSF, provide trophic factors necessary to brain development. They also express detoxifying enzymes that protect developing from harmful substances. Targeting Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway may enhance detoxification capabilities of choroid are linked glutathione conjugation, but little is known about mechanisms enzyme induction in this tissue. Rat pups were treated with dimethylfumarate subcellular localization Nrf2 was analyzed choroidal tissue by confocal imaging. Glutathione-S-transferase (GST) activity assessed ex vivo tissue, 1-chloro-2,4-dinitrobenzene, a toxicant prototypic GST substrate, used evaluate efficiency glutathione-dependent enzymatic barrier function plexuses. knockout rat establish dependency We show an early postnatal expression Treatment triggers nuclear translocation epithelial cells. This treatment increases plexus, reduces blood-to-CSF permeation 1-chloro-2,4-dinitrobenzene. In rats, constitutive machinery maintained, efficacy induce conjugation strongly reduced, indicating acts mainly through pathway. work shows blood-CSF can be pharmacologically enhanced better neural fluid environment drug toxic accumulation during neonatal period.

Language: Английский

Citations

0
The relationship between ferroptosis and respiratory infectious diseases: a novel landscape for therapeutic approach DOI Creative Commons

Hong Lin,

Xiangyu Chen, Yiming Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Respiratory infectious diseases, particularly those caused by respiratory viruses, have the potential to lead global pandemics, thereby posing significant threats public and human health. Historically, primary treatment for bacterial infections has been antibiotic therapy, while severe cases of viral predominantly managed controlling inflammatory cytokine storms. Ferroptosis is a novel form programmed cell death that distinct from apoptosis autophagy. In recent years, Recent studies demonstrated ferroptosis plays regulatory role in various indicating targeting may represent approach these conditions. This article summarized toxic mechanisms underlying ferroptosis, its relationship with action, current strategies. Particular attentions were given interplay between Mycobacterium tuberculosis, Epstein-Barr virus, acute syndrome coronavirus-2, Pseudomonas aeruginosa, dengue influenza virus herpes simplex type1infection. A deeper understanding will not only advance our knowledge infection-related pathophysiology but also provide theoretical foundation development therapeutic Targeting pathways represents promising infections, clinical translational implications.

Language: Английский

Citations

0
Investigate the protective effects of eicosapentaenoic acid in human astrocytes of oxidative stress damage and explore its underlying mechanisms DOI
Che‐Sheng Chu, Ying-Tso Chen, Wei‐Chih Sun

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 15, 2025

Language: Английский

Citations

0
Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders DOI Open Access
Jed W. Fahey, Hua Liu,

Holly Batt

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1353 - 1353

Published: April 15, 2025

The brain accounts for about 2% of the body’s weight, but it consumes 20% energy at rest, primarily derived from ATP produced in mitochondria. thus has a high mitochondrial density its neurons because extensive demands maintaining ion gradients, neurotransmission, and synaptic activity. is also extremely susceptible to damage dysregulation caused by inflammation (neuroinflammation) oxidative stress. Many systemic challenges can be mitigated phytochemical sulforaphane (SF), which particularly important supporting function. SF or biogenic precursor glucoraphanin, broccoli seeds sprouts, confer neuroprotective cognitive benefits via diverse physiological biochemical mechanisms. able cross blood–brain barrier as well protect it, mitigates consequences destructive neuroinflammation. It protects against neurotoxic effects environmental pollutants, combats tissue cell wrought advanced glycation end products (detoxication), supports healthy glucose metabolism. These are applicable individuals all ages, developing brains periconception infancy, cognitively, developmentally, traumatically challenged brains, those later life who suffering with multiple chronic conditions including Parkinson’s Alzheimer’s diseases.

Language: Английский

Citations

0