Exposure to polycyclic aromatic hydrocarbons (PAHs) in outdoor air and respiratory health, inflammation and oxidative stress biomarkers: A panel study in healthy young adults

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 899, P. 165582 - 165582

Published: July 18, 2023

Language: Английский

---

Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1256 - 1256

Published: Oct. 17, 2024

Environmental pollution continues to increase with industrial development and has become a threat human health. Atmospheric particulate matter (PM) was designated as Group 1 carcinogen by the International Agency for Research on Cancer in 2013 is an emerging global environmental risk factor that major cause of death related cardiovascular respiratory diseases. PM complex composed highly reactive organic matter, chemicals, metal components, which mainly excessive production oxygen species (ROS) can lead DNA cell damage, endoplasmic reticulum stress, inflammatory responses, atherosclerosis, airway remodeling, contributing increased susceptibility exacerbation various diseases infections. effects health depending particle size, physical chemical characteristics, source, exposure period. smaller than 5 μm penetrate accumulate alveoli circulatory system, causing harmful skin, brain. In this review, we describe relationship mechanism ROS-mediated oxidative responses caused organs, well comprehensively discuss harmfulness PM.

Language: Английский

---

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 803 - 803

Published: May 8, 2024

Recent evidence indicates that exposure to environmental toxins, both short-term and long-term, can increase the risk of developing neurological disorders, including neurodegenerative diseases (i.e., Alzheimer's disease other dementias) acute brain injury stroke). For stroke, latest systematic analysis revealed ambient particulate matter is second most frequent stroke after high blood pressure. However, preclinical clinical investigations on deleterious consequences pollutants are scarce. This review examines recent how absorbed along digestive tract or inhaled through lungs, affect host cellular response. We particularly address toxins immune response microbiome at gut lung barrier sites. Additionally, this highlights findings showing potential contribution an increased stroke. A better understanding biological mechanisms underlying has mitigate disorders.

Language: Английский

---

Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis

Cellular & Molecular Biology Letters, Journal Year: 2023, Volume and Issue: 28(1)

Published: Nov. 25, 2023

Long-term exposure of humans to air pollution is associated with an increasing risk cardiovascular diseases (CVDs). Astaxanthin (AST), a naturally occurring red carotenoid pigment, was proved have multiple health benefits. However, whether or not AST also exerts protective effect on fine particulate matter (PM2.5)-induced cardiomyocyte damage and its underlying mechanisms remain unclear.In vitro experiments, the H9C2 cells were subjected pretreatment varying concentrations AST, then injury model induced by PM2.5 established. The cell viability ferroptosis-related proteins expression measured in different groups. In vivo rats pretreated for 21 days. Subsequently, rat myocardial established intratracheal instillation every other day 1 week. effects tissue caused indicating histological, serum, protein analyses examined.AST significantly ameliorated PM2.5-induced injury, inflammatory infiltration, release factors, damage. Mechanistically, increased SLC7A11, GPX4 down-regulated TfR1, FTL FTH1 vivo.Our study suggest that ferroptosis plays significant role pathogenesis PM2.5. may serve as potential therapeutic agent mitigating through inhibition ferroptosis.

Language: Английский

---

Independent and combined associations of polycyclic aromatic hydrocarbons exposure and sleep disorders among adults in the U.S. adult population

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 350, P. 319 - 327

Published: Jan. 13, 2024

Language: Английский

---

Mutated IL-32θ (A94V) inhibits COX2, GM-CSF and CYP1A1 through AhR/ARNT and MAPKs/NF-κB/AP-1 in keratinocytes exposed to PM10

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 15, 2025

Language: Английский

---

Exposure to urinary polycyclic aromatic hydrocarbon metabolites for the effect of lung function among children and adolescents: Epidemiological study and mechanism exploration

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117990 - 117990

Published: March 1, 2025

Human are widely exposed to polycyclic aromatic hydrocarbon (PAHs), but existing evidence about exposure urinary PAHs metabolites for pulmonary health in children and adolescents is limited. Our aim was examine the effect of single mixed on lung function among adolescents. We included 1417 individuals aged 6-19 years from 3 survey cycles (2007-2008, 2009-2010, 2011-2012) NHANES program. Multivariable linear regression model conducted relationship between index including FEV1, FVC FEV1/FVC. BKMR WQS were used evaluate joint effects index. Mediation analyses performed investigate mediating role inflammation related Hub proteins screened by network toxicology validated using molecular docking. results indicated that 3-FLU negatively linked with FEV1 FEV1/FVC; 1-OHP FEV1; 1-PYR FVC. In addition, 3-OHP positively corrected three parameters. models, co-exposure all Systemic response mediated I-PYR as well FVC, 8 % 6 proportion. IL-6, STAT3, TNF, TP53 common targets PAHs, docking analysis. Taken together, our findings raise concerns potential hazards environmentally relevant respiratory system vulnerable population guide future research into toxic mechanisms metabolites-mediated injury, which has important public implications.

Language: Английский

---

Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice

The Journal of Toxicological Sciences, Journal Year: 2025, Volume and Issue: 50(3), P. 147 - 159

Published: Jan. 1, 2025

Exposure to fine particulate matter (PM2.5) has been epidemiologically reported worsen the prognosis of ischemic stroke; however, details have not investigated. One major toxic mechanisms PM2.5 inhalation is oxidative stress, which mediated by reactive oxygen species generated components such as metals and polycyclic aromatic hydrocarbons. In this study, we examined effects long-term exposure urban matter, focusing on after stroke in mice. When mice were intranasally exposed for 28 days an aerosol collected Beijing, China (CRM28), microglial activation was observed cerebral cortex, indicating that CRM28 induced neuroinflammation. resulted increased serum levels brain natriuretic peptide troponin I, suggesting cardiac injury elicited CRM28. Lung inflammation also following exposure; systemic detected. Mice showed exacerbation mortality induction compared with vehicle A vitamin E-rich diet suppressed CRM28-induced lipid peroxidation heart lungs but brain. attenuated lung exposure, whereas neuroinflammation affected. Mortality improved administration a diet. Considering did occur, stress under may be involved stroke. Antioxidation air pollution fundamental protection against

Language: Английский

---

Unraveling the mechanisms underlying air pollution-induced dysfunction of the oral–gut–brain axis: implications for human health and well-being

Asian Biomedicine, Journal Year: 2025, Volume and Issue: 19(1), P. 21 - 35

Published: Feb. 1, 2025

Air pollution exposure has become an international health issue that poses many risks to life and health. The bidirectional regulatory network, known as the oral-gut-brain axis connects oral cavity, intestine, central nervous system, well its influence on outcomes from air is receiving increased attention. This article systematically details epidemiological evidence linking pollutants diseases affecting oral, respiratory, intestinal, systems, while also explaining route of via axis. anomalies resulting their underlying molecular processes are covered. study provides a fresh viewpoint how affects investigates cutting-edge preventative therapeutic techniques.

Language: Английский

---

A simple air–liquid interface exposure system for exposing cultured human 3D epidermis and cornea to PM2.5 collected through cyclonic separation

The Journal of Toxicological Sciences, Journal Year: 2024, Volume and Issue: 49(2), P. 61 - 68

Published: Jan. 1, 2024

Particulate matter (PM) is among the major air pollutants suspended in atmosphere. PM2.5 has a particle size of 2.5 µm; it known to cause inflammation, especially respiratory tract and skin. Since skin acts primary barrier against harmful environmental substances that may enter body, highly exposed present environment. However, adverse health effects exposure on human have not been accurately examined due lack system exposes epidermal tissue actual concentration PM2.5. In this study, we developed an air–liquid interface for exposing cultured 3D epidermis cornea collected through cyclonic separation. suspension was nebulized acrylic chamber, resulting mist pumped diffusion dryer into glass chamber. A counter connected chamber continuously measure spatial mass PM. Human Exposure PM aerosol increased interleukin-8 release media around 50 µg/m3. Mass concentrations above 100 µg/m3 caused cell death. Furthermore, corneal model showed similar responses as epidermis. The study considered useful evaluating induced by can be used alternative experiments involving or animals.

Language: Английский

---