The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

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Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Recent analytical advancements have uncovered increasing micro- and nanoplastics (MNPs) in environmental, dietary, biological domains, raising concerns about their health impacts. Preterm birth (PTB), a leading cause of maternal neonatal morbidity mortality, may be influenced by MNP exposure, yet this relationship remains unexplored. This study quantified 12 polymers placentae from term (n=87) preterm (n=71) deliveries using pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). Cumulative concentrations were 28% higher PTB (mean ±SD: 224.7 ± 180.7 µg/g vs. 175.5 137.9 µg/g; p=0.038). Polyvinyl chloride (PVC), polyethylene terephthalate (PET), polyurethane (PU), polycarbonate (PC) significantly elevated PTB, PET, PU, PC inversely correlated with gestational age weight. Logistic regression identified PVC as independent predictors PTB. These findings suggest total specific MNPs are associated providing actionable insights emphasizing the importance minimizing exposure during pregnancy.

Language: Английский

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Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 15, 2025

The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in literature. Numerous studies have demonstrated that activation epidermal growth factor receptor 4 (ErbB4) is crucial neuronal injury and regeneration processes. This study investigated role targeted ErbB4 through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), mitigating PS-MPs-induced injury. findings revealed significantly ameliorated cognitive behavioral deficits mice exposed to PS-MPs. Furthermore, E4A treatment upregulated expression dedicator cytokinesis 3 (DOCK3) Sirtuin (SIRT3) mitigated mitochondrial synaptic dysfunction within hippocampus PS-MPs-exposed mice. also diminished TLR4-NF-κB-NLRP3 signaling pathway, consequently reducing neuroinflammation. In vitro experiments partially alleviated hippocampal its effects microglial inflammation. conclusion, this indicate may mitigate damage subsequent neuroinflammation, thereby alleviating induced by PS-MPs exposure ameliorating dysfunction. These results offer valuable insights for development potential therapeutic strategies.

Language: Английский

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Gestational exposure to polystyrene microplastics incurred placental damage in mice: Insights into metabolic and gene expression disorders

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118056 - 118056

Published: March 19, 2025

Language: Английский

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Navigating redox imbalance: the role of oxidative stress in embryonic development and long-term health outcomes

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 26, 2025

Embryonic development is a complex process of concurrent events comprising cell proliferation, differentiation, morphogenesis, migration, and tissue remodeling. To cope with the demands arising from these developmental processes, cells increase their nutrient uptake, which subsequently increases metabolic activity. Mitochondria play key role in maintenance metabolism production reactive oxygen species (ROS) as natural byproduct. Regulation ROS by antioxidants critical tightly regulated during embryonic development, dysregulation results oxidative stress that damages essential cellular components such DNA, proteins, lipids, are crucial for extension development. However, exposure to certain exogenous factors or damage can result an imbalance between its neutralization antioxidants, leading detrimental effects on process. In this review article, we highlight redox homeostasis normal how disruptions balance may defects.

Language: Английский

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Impact and mechanisms of microplastics and nanoplastics on the reproductive system

Molecular & Cellular Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Language: Английский

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Unveiling micro- nanoplastics (MNPs) induced developmental toxicity, transgenerational transport and associated signaling pathways

Journal of Hazardous Materials Advances, Journal Year: 2024, Volume and Issue: unknown, P. 100581 - 100581

Published: Dec. 1, 2024

Language: Английский

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