Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 156, P. 104841 - 104841
Published: Dec. 11, 2024
Language: Английский
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137624 - 137624
Published: Feb. 19, 2025
Microplastics and nanoplastics (MNPs) have implicated in cardiovascular disease preclinical studies. Our objective is to investigate the relationship between MNPs coronary arteries major adverse cardiac events (MACE) patients with myocardial infarction (MI).We conducted a prospective observational study involving undergoing angiography for MI. Coronary blood samples were analyzed presence of using pyrolysis-gas chromatography-mass spectrometry. A total 142 enrolled, 110 completing 31.5-month follow-up. Among them, 48 (43.6 %) had detectable polystyrene, 79 (71.8 polyethylene, 105 (95.4 polyvinyl chloride (PVC), 68 (61.8 polyamide 66 their blood. PVC concentration was higher who experienced MACE. Furthermore, levels positively associated proinflammatory factors (IL-1β, IL-6, IL-18, TNF-α), odds MACE (OR: 1.090, 95 %CI: 1.032-1.1523, P = 0.002). Notably, each 10-unit increase PVC, there 1.374-fold risk (OR=2.374, 1.366-4.128, Additionally, we collected thrombus from an additional 21 MI patients, finding that thrombi correlated inflammatory markers monocyte/macrophage infiltration.
Language: Английский
Citations
1
Environmental Technology & Innovation, Journal Year: 2025, Volume and Issue: 38, P. 104069 - 104069
Published: Feb. 7, 2025
Language: Английский
Citations
0
SciComm Report, Journal Year: 2025, Volume and Issue: 5(1), P. 1 - 12
Published: Feb. 27, 2025
El uso de plásticos en la atención salud plantea una paradoja crítica, mientras facilita médica, pero su eliminación inadecuada amenaza humana y planetaria. Existe un impacto ambiental el sector salud, destacando que hasta 83% los residuos hospitalarios a nivel global pueden ser plásticos, con efectos nocivos para como cáncer, afecciones cardiovasculares enfermedades respiratorias. En Chile, solo 2% se reciclan, 98% dispone vertederos. La presencia microplásticos fluidos tejidos humanos, sangre bulbo olfatorio, expone gravedad del problema. exposición prolongada asocia patologías oncológicas, respiratorias, comprometiendo principio ético “no hacer daño”. Por lo anterior, existe necesidad integrar estrategias sostenibles gestión hospitalarios, implementación equipos “Green Teams” reducir insumos desechables, reutilizar materiales fomentar reciclaje. adhesión 233 instituciones Red Global Hospitales Verdes Saludables marca avance, persisten desafíos educación profesionales políticas efectivas. este contexto, enfermería posiciona actor clave liderar cambio, dada capacidad intervención directa clínica, formación académica residuos. sostenibilidad debe eje central transformación proponiendo mallas curriculares fortalecimiento investigación local formulación públicas. Este enfoque asegura equilibrio entre calidad pacientes protección planeta, garantizando futuro más saludable todos.
Citations
0
Atherosclerosis, Journal Year: 2025, Volume and Issue: unknown, P. 119160 - 119160
Published: March 1, 2025
Soil and water pollution represent significant threats to global health, ecosystems, biodiversity. Healthy soils underpin terrestrial supporting food production, biodiversity, retention, carbon sequestration. However, soil degradation jeopardizes the health of 3.2 billion people, while over 2 live in water-stressed regions. Pollution soil, air, is a leading environmental cause disease, contributing 9 million premature deaths annually. contamination stems from heavy metals, synthetic chemicals, pesticides, plastics, driven by industrial activity, agriculture, waste mismanagement. These pollutants induce oxidative stress, inflammation, hormonal disruption, significantly increasing risks for non-communicable diseases (NCDs) such as cardiovascular disease (CVD). Emerging contaminants like micro- nanoplastics amplify through cellular damage, dysfunction. Urbanization climate change exacerbate deforestation, overfertilization, pollution, further threatening ecosystem sustainability human health. Mitigation efforts, reducing chemical exposure, adopting sustainable land-use practices, advancing urban planning, have shown promise lowering pollution-related impacts. Public initiatives, stricter controls, lifestyle interventions, including antioxidant-rich diets, can also mitigate risks. remains preventable, demonstrated high-income nations implementing cost-effective solutions. Policies European Commission's Zero-Pollution Vision aim reduce safe levels 2050, promoting ecosystems public Addressing critical combating burden NCDs, particularly CVDs, fostering healthier environment future generations.
Language: Английский
Citations
0
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Journal Year: 2025, Volume and Issue: 903, P. 503865 - 503865
Published: March 6, 2025
Plastic is used extensively worldwide. However, plastic particles that are less than 1000 nm (i.e. nanoplastics) may be hazardous to human cells. Nanoplastics might manufactured intentionally or formed in the environment by degradation of larger items. Ingestion and inhalation two most common routes exposure nanoplastics, indicating epithelial cells have direct exposure. immune will also interact with during tissue inflammation. An assessment published studies suggests polystyrene (PS) generate higher levels DNA damage compared cells, although it has not been formally studied under same experimental condition. To investigate this, we assessed cytotoxicity, oxidative stress strand breaks lung (A549) intestinal (Caco-2) monocytes (THP-1 U937) after amine-functionalized (PS-NH2) declared particle size 240 nm. No cytotoxicity intracellular reactive oxygen species production were found at concentrations up 200 µg/mL. Exposure PS-NH2 was associated glutathione depletion A549 there no increase level breaks, measured comet assay, any cell lines standard assay conditions. Diethyl maleate treatment render susceptible stress. By itself, diethyl led approximately 50 % increased but additional observed A549, Caco-2, THP-1 U937
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837
Published: March 21, 2025
There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.
Language: Английский
Citations
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Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
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TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118270 - 118270
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 25, 2024
Microplastics (MPs), defined as plastic particles smaller than 5 mm, are increasingly recognized environmental contaminants with potential health risks. These emerge breakdown products of larger plastics and omnipresent in marine, freshwater, terrestrial ecosystems. They primarily composed polymers such polyethylene, polypropylene, polystyrene, additives that enhance their performance. MPs also adsorb harmful chemicals like persistent organic pollutants heavy metals, posing risks to human health. Human exposure occurs mainly through ingestion inhalation, detected food products, water, even the air. have been shown accumulate gastrointestinal tract, disrupting gut microbiome, causing dysbiosis-a imbalance between beneficial bacteria. This disruption has linked various issues, including disorders, systemic inflammation, chronic diseases. Furthermore, gut-brain axis may be affected, neuroinflammatory consequences. As research continues unravel impacts MP exposure, understanding mechanisms accumulation broader implications on is crucial. review highlights effects health, emphasizing impact microbiome. We discuss connections cardiometabolic inflammatory diseases, disorders related Gut-Brain Axis. By synthesizing latest research, this work sheds light silent yet pervasive threat posed by underscores importance further studies understand fully.
Language: Английский
Citations
2
Current Reviews in Musculoskeletal Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
Abstract Purpose of Review The physical health impacts microplastics have received increasing attention in recent years. However, limited data impedes a full understanding the internal exposure to microplastics, especially concerning musculoskeletal system. purpose this review is summarize literature regarding effects on Recent Findings Microplastics been shown cause abnormal endochondral ossification and disrupt normal function pre-osteoblasts, osteocyte-like cells, pre-osteoclasts through gene mutations, endoplasmic reticulum stress induction, reduced autophagosome formation bone growth areas. Although there are few reports their muscle, it has noted that inhibit energy lipid metabolism, decrease type I muscle fiber density, impair angiogenesis, atrophy, increase deposition. Summary Only studies interfere with growth-related cells reduce mass quality. This underscores need for further research into other parts system using human tissues at disease level.
Language: Английский
Citations
0