Polystyrene Nanoplastics Hitch-Hike the Gut–Brain Axis to Exacerbate Parkinson’s Pathology

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

The neurological implications of micro- and nanoplastic exposure have recently come under scrutiny due to the environmental prevalence these synthetic materials. Parkinson's disease (PD) is a major disorder clinically characterized by intracellular Lewy-body inclusions dopaminergic neuronal death. These pathological hallmarks PD, according Braak's hypothesis, are mediated afferent propagation α synuclein (αS) via enteric nervous system, or so-called gut-brain axis. Here we first examined effect polystyrene nanoplastics on peripheral central pathogenesis A53T, representative αS mutant. Specifically, accelerated amyloid aggregation A53T αS, which subsequently elevated in vitro production glial activation biomarkers, cytokines, reactive oxygen species compromised mitochondrial lysosomal membrane integrity, further shifting cellular metabolite profiles association with PD pathophysiology. In vivo, coadministration facilitated their synergistic gut-to-brain transmission mice, leading progressive impairment physical motor skills resemblance characteristic symptoms. This study provides insights into response vulnerability axis nanoplastics.

Language: Английский

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A brief history of microplastics effect testing: Guidance and prospect

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125711 - 125711

Published: Jan. 1, 2025

Numerous reviews have consistently highlighted the shortcomings of studies evaluating effects microplastics (MP), with many issues identified in 2016 still relevant 2024. Here, we summarize current knowledge on MP effect testing, compare guidelines, and provide an overview risk assessments conducted at both single species community levels. We discuss standard test materials, characteristics, mechanisms explaining effects. observed that quality is gradually improving, enhancing these available. Recommendations include data rescaling alignment for ecological assessment, preference using environmentally MPs. A step-by-step protocol creating polydisperse materials provided. Most indicate concentrations ecosystems globally exceed thresholds measured laboratory. However, a higher-tier approach, no risks are expected freshwater benthic communities exposure concentrations. Evidence behind adverse growing; however, more well-designed experiments needed. potential solution might involve comparing natural particles MPs as similar dimensions possible, providing insight into food dilution where volume critical determinant toxicity.

Language: Английский

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Acute and partial life-cycle toxicity of a tri-polymer blend of microplastics in the copepod Acartia tonsa

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126105 - 126105

Published: March 1, 2025

Language: Английский

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Nanoplastic and microplastic polystyrene particles' ecotoxicological effect on the Hyalella azteca – The comprehensive study of the impact of physical andchemical surface properties

Journal of Contaminant Hydrology, Journal Year: 2025, Volume and Issue: unknown, P. 104574 - 104574

Published: April 1, 2025

Language: Английский

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Production of detergent-free PET and biodegradable PBAT micro- and nanoplastics

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 493, P. 138371 - 138371

Published: April 22, 2025

Language: Английский

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