Microwave-Assisted Synthesis of Morpholine-Based Chalcones as Reversible MAO-A Inhibitors in the Management of Mental Depression
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 309 - 309
Published: Feb. 23, 2025
Background:
Depression
is
one
of
the
most
serious
and
common
health
problems
among
youth
population
responsible
for
initiation
many
diseases.
As
per
World
Health
Organization,
3.8%
suffers
from
mental
depression,
globally.
The
monoamine
oxidase-A
(MAO-A)
enzyme
degradation
neurotransmitters
leading
to
lower
levels
neurotransmitters.
Methods:
Chalcones
(C1-C15)
were
synthesized
by
reacting
substituted
acetophenone
with
various
benzaldehydes
in
a
basic
ethanolic
solvent
at
80
°C
under
microwave
irradiation
conditions.
To
compare
reaction
time
product
yield,
conventional
method
synthesis
chalcones
was
also
performed.
spectroscopically
characterized
screened
initially
inhibitory
activities
against
MAO-A
MAO-B.
best
active
compounds
undertaken
IC50
determination
followed
reversibility
inhibition
analysis
antioxidant
assay.
Moreover,
silico
molecular
docking
ADME
pharmacokinetic
investigations
accomplished.
Results:
Most
inhibited
MAO-A,
specifically,
C14
C6
exhibited
highest
values
7.91
±
0.08
μM
8.45
0.19
μM,
respectively.
Both
these
reversible
displaying
up
60%
recovery
enzymatic
activity
when
diluted
substrate
(Tyramine).
results
study
indicated
scores
−9.56
Kcal/mol
(C14)
−9.45
(C6)
π-π
stacking
interaction
crucial
amino
acid
Trp-397.
determined
cross
blood–brain
barrier
(BBB)
displayed
favorable
gastrointestinal
(GI)
absorption.
Further,
assay
demonstrated
that
possess
modest
free
radical
scavenging
potential.
Conclusions:
This
potential
morpholine-substituted
as
promising
pharmacophore
development
novel
antidepressant
lead
compounds.
Language: Английский
Effectiveness of a cognitive-behavioral sleep intervention for adolescents with ADHD: A randomized controlled trial
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Abstract
Objective:
Sleep
problems
are
frequent
and
impairing
in
adolescents
with
ADHD.
This
randomized
controlled
trial
investigates
the
effectiveness
of
a
newly
developed
CBT
sleep
intervention
for
ADHD
–
SIESTA.
Method:
Adolescents
(N
=
92,
Mage
14.36,
SD
1.43,
47%
males)
were
to
receive
SIESTA
next
treatment
as
usual
targeting
(SIESTA+TAU)
or
TAU
only.
Adolescent
parent
ratings,
actigraphy
diaries,
collected
at
pre-,
post-,
4
month
follow-up
test.
A
linear
mixed
effects
model
was
used
an
intent-to-treat
approach.
Results:
Results
indicated
significant
improvement
SIESTA+TAU
compared
from
pre-
post-test
on
hygiene
(partial
eta
squared
.21),
chronic
reduction
.15),
sleep-wake
problem
behaviors
.05).
Actigraphy
diaries
showed
no
differences,
both
groups
improving
diaries.
The
improvements
maintained
.09).
Of
secondary
outcomes,
depressive
symptoms
reduced
significantly
more
than
only
Conclusions:
study
indicates
that
is
effective
hygiene,
perceived
problems,
However,
maintain
long-term
effects,
booster
sessions
may
be
beneficial.
Language: Английский
Ensuring Data Privacy in Teen and Children Mental Health Analytics: The Role of Differential Privacy in Data Engineering
International Journal of Scientific Research in Computer Science Engineering and Information Technology,
Journal Year:
2024,
Volume and Issue:
10(6), P. 1334 - 1341
Published: Dec. 7, 2024
This
article
examines
the
critical
intersection
of
youth
mental
health
data
analytics
and
privacy
preservation
technologies,
focusing
on
differential
implementations.
The
explores
growing
crisis
among
adolescent
populations
subsequent
need
for
data-driven
interventions
while
maintaining
stringent
protections.
It
analyzes
effectiveness
frameworks
in
protecting
sensitive
information
enabling
valuable
research
insights
across
educational
healthcare
settings.
comprehensively
evaluates
privacy-preserving
mechanisms,
including
budget
management,
noise
addition
techniques,
implementation
challenges
various
institutional
contexts.
An
examination
real-world
applications
school-based
programs
platforms
it
demonstrates
how
privacy-enhanced
can
support
effective
individual
regulatory
compliance.
Language: Английский